Vaginal lactobacillus medicant
First Claim
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1. A vaginal medicant, comprising:
- a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising;
(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions.
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Abstract
Disclosed are novel isolated strains of bacteria of the genus Lactobacillus which are useful in a vaginal medicant. Also disclosed are medicants containing such Lactobacilli, a novel preservation matrix for microorganisms, a method for preserving microbial cells within a medicant, and methods for preventing and treating vaginal and gastrointestinal infections.
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Citations
23 Claims
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1. A vaginal medicant, comprising:
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a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising;
(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method to reduce the risk of infection in a female from a vaginal infection, comprising administering to a female a vaginal medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions. - View Dependent Claims (14)
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15. A method to treat a vaginal infection, comprising administering to a female having a vaginal infection a vaginal medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions.
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16. A method to reduce the risk of infection of a human by human immunodeficiency virus (HIV), comprising administering to a human a medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions. - View Dependent Claims (17)
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18. A method to prevent infection of a human by symptomatic yeast vaginitis, comprising administering to a human a medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions. - View Dependent Claims (19)
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20. A method to reduce the risk of infection of a human by a gastrointestinal infection, comprising administering to a human a medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions.
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21. A method to reduce the occurrence of preterm birth, comprising administering to a pregnant female a medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions.
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22. A method to enhance metabolism of estrogen in the vagina and bowel, comprising administering to a female a vaginal medicant comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions.
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23. A gastrointestinal medicant, comprising a bacterial culture of an isolated strain of the genus Lactobacillus having identifying characteristics comprising:
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(i) a percent vaginal epithelial cell (VEC) cohesion value of greater than 50%; and
(ii) an ability to produce greater than 0.5 ppm of H2O2 under effective culture conditions.
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Specification