Method to promote, stimulate and/or delay hair loss by a brady kinin antagonist

• US 6,468,972 B1
• Filed: 02/11/1998
• Issued: 10/22/2002
• Est. Priority Date: 10/06/1995
• Status: Expired due to Fees

• Current Assignee: L'Oreal SA
• Original Assignee: Societe L'Oreal S.A.
• Inventors: Pruche, Francis, Duranton, Albert, Gautier, Brigitte, Boyera, Nathalie
• Primary Examiner(s): CELSA, BENNETT M
• Application Number:
  US08/981,279
• Time in Patent Office: 1,714 Days
• Field of Search: 514/2, 514/15, 514/880, 530/328, 424/70.1, 424/401
• US Class Current: 514/18.1
• CPC Class Codes: A61K 38/043 Kallidins; Bradykinins; Related peptides
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The present invention is directed to a method to promote, stimulate and/or delay hair loss by administering an effective amount of at least one bradykinin antagonists to promote, stimulate and/or delay hair loss to an individual in need thereof.

Claims

1. A method to promote or stimulate hair growth and/or delay hair loss, said method comprising administering an effective amount of at least one bradykinin antagonist to promote or stimulate hair growth and/or delay hair loss to an individual in need thereof, wherein said bradykinin antagonist binds to a B1 and/or B2 bradykinin receptor.

2. A method to promote or stimulate hair growth and/or delay hair loss comprising administering an effective amount of at least one bradykinin antagonist in an amount effective to promote, stimulate and/or delay hair loss wherein said bradykinin antagonist is selected from

D-Arg (Hyp3, D-Phe7)-bradykinin (NPC567);

(Thi5,8, D-Phe7)-bradykinin;

D-Arg, (Hyp3, Thi5,8, D-Phe7)-bradykinin;

N-α

-adamantaneacetyl-D-Arg (Hyp3, Thi5,8, D-Phe7)-bradykinin;

des-Arg9, (Leu8)-bradykinin;

P-guanidobenzoyl (Hyp3, Thi5, D-Tic7, Oic8)-bradykinin (S

     16118);

D-Arg (Hyp3, Thi5, D-Tic7, Oic8)-bradykinin (HOE

     140); and

D-Arg, (Hyp3, D-Hype (transpropyl)7, Oic8)-bradykinin (NPC

     17731).

3. The method of claim 2 wherein said bradykinin antagonist is D-Arg (Hyp3, Thi5, D-Tic7, Oic8)-bradykinin (HOE 140).

4. A process for the cosmetic treatment of the hair and/or scalp comprising administering an effective amount of a cosmetic composition wherein said composition comprises at least one bradykinin antagonist in a physiologically acceptable medium, in an amount effective to promote or stimulate hair growth and/or delay hair loss in said subject wherein said bradykinin antagonist binds to a B1 and/or B2 bradykinin receptor.

5. The process for cosmetic treatment of the hair and/or scalp of claim 4 wherein said bradykinin antagonist is selected from

D-Arg (Hyp3, D-Phe7)-bradykinin (NPC567);

(Thi5,8, D-Phe7)-bradykinin;

D-Arg, (Hyp3, Thi5,8, D-Phe7)-bradykinin;

N-α

-adamantaneacetyl-D-Arg (Hyp3, Thi5,8, D-Phe7)-bradykinin;

des-Arg9, (Leu8)-bradykinin;

P-guanidobenzoyl (Hyp3, Thi5, D-Tic7, Oic8)-bradykinin (S

     16118);

D-Arg (Hyp3, Thi5, D-Tic7, Oic8)-bradykinin (HOE

     140); and

D-Arg, (Hyp3, D-Hype (transpropyl)7, Oic8)-bradykinin (NPC

     17731).

6. The process for cosmetic treatment of the hair and/or scalp of claim 4 wherein said antagonist is D-Arg (Hyp3, Thi5, D-Tic7, Oic8)-bradykinin (HOE 140).

7. The process of claim 4 wherein said cosmetic composition is administered to the hair and/or scalp.

8. The process of claim 6 wherein said cosmetic composition is left in contact with the hair and/or scalp.