Method of imaging by SPECT

• US 6,469,306 B1
• Filed: 05/18/2000
• Issued: 10/22/2002
• Est. Priority Date: 08/19/1997
• Status: Expired due to Fees

• Current Assignee: Adrianus A. Van Dulmen
• Original Assignee: Adrianus A. Van Dulmen
• Inventors: Walrand, Stéphan, Van Dulmen, Adrianus A.
• Primary Examiner(s): Hannaher, Constantine
• Application Number:
  US09/485,841
• Time in Patent Office: 887 Days
• Field of Search: 250/363.1, 250/363.04
• US Class Current: 250/363.04
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/1648 Ancillary equipment for scintillation cameras, e.g. reference markers, devices for removing motion artifacts, calibration devices adapted for flow studies G01T1/1647
• CPC Class Codes: G01T 1/2985 In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02

Abstract

A method of imaging a target organ in a patient by SPECT, by using a gamma camera having a gamma detector provided with a fan-beam collimator (2), focusing to a focal line parallel to the patient'"'"'s body length, and by computer reconstructing the distribution of the radioactivity inside the patient'"'"'s body from the acquired planar images by using certain reconstruction algorithms. The images are acquired along at least one linear orbit performed in a direction perpendicular to the patient'"'"'s body, and the collimator focal line is made to travel throughout said target organ during the acquisition. The invention further relates to an equipment for performing this method.

Claims

1. A method of imaging a target organ in a patient by SPECT, by using a gamma camera having a detector/collimator combination including a gamma detector provided with a fan-beam collimator, comprising:

focusing the collimator to a focal line parallel to the patient'"'"'s body length;

acquiring planar images by relative movement between the gamma camera and the patient'"'"'s body along at least on linear path in a direction perpendicular to the patient'"'"'s body length so that the collimator focal line traverses said target organ; and

computer reconstructing the distribution of the radioactivity inside the patient'"'"'s body from the acquired planar images by using reconstruction algorithms.

2. The method of claim 1, wherein the images are acquired along four, mutually orthogonal, linear paths in directions perpendicular to the patient'"'"'s body length.

3. The method of claim 1, wherein the collimator remains parallel to its initial position along each linear path.

4. The method of claim 1, wherein two detector/collimator combinations are used simultaneously and in positions on opposite sides of the patient'"'"'s body.

5. The method of claim 1, wherein four detector/collimator combinations are used simultaneously and each two of the four detector/collimator combinations are positioned on opposite sides of the patient'"'"'s body, and wherein the images are acquired by moving each of the detector/collimator combinations along a linear path.

6. The method of claim 1, wherein at least one gamma detector is used with at least one fan-beam collimator having a focal length of between about 12 and 30 cm.

7. The method of claim 6, wherein the focal length of the at least one fan-beam collimator is about 25 cm.

8. The method of claim 6, wherein the fan-beam collimator comprises first septa members arranged in a fan-shape pattern in which all the first septa members are oriented towards a common focal line, and second septa members arranged to be parallel to each other, the second septa members perpendicularly crossing with the first septa members in a lattice shape such that holes with a longitudinal cross section are defined between each adjacent first septa member and each adjacent second septa member.

9. A method of any one of claims 2-8, wherein the following reconstruction algorithm, is used:

$A<br><br>\left(x,y,z\right)=\frac{1}{{\left(2<br><br>\mathrm{\pi <br><br>}\right)}^2<br><br>f}<br><br>{\int <br><br>}_{-f}^f<br><br><br><br>r<br><br>\text{\hspace{1em}<br><br>}<br><br>\left({\tilde{P}}_{\mathrm{left}}<br><br>\left(\frac{r}{f}<br><br>x+y,r,z\right)+{\tilde{P}}_{\mathrm{under}}<br><br>\left(\frac{r}{f}<br><br>y+x,r,z\right)+{\tilde{P}}_{\mathrm{right}}<br><br>\text{\hspace{1em}<br><br>}(\text{\hspace{1em}<br><br>}<br><br>\frac{r}{f}<br><br>x+y,r,z)+{\tilde{P}}_{\mathrm{over}}<br><br>\left(\frac{r}{f}<br><br>y+x,r,z\right)\right)$${\tilde{P}}_{\mathrm{\alpha <br><br>}}<br><br>\left(W,r,z\right)=\frac{1}{2<br><br>\mathrm{\pi <br><br>}}<br><br>{\int <br><br>}_{-\mathrm{\infty <br><br>}}^{+\mathrm{\infty <br><br>}}<br><br><br><br>k<br><br>\text{\hspace{1em}<br><br>}<br><br>{\mathrm{<br><br>}}^{\mathrm{ikW}}<br><br><br><br>k<br><br><br><br>{\mathrm{<br><br>}}^{-{\mathrm{ikU}}_{\mathrm{\alpha <br><br>}<br><br>\frac{r}{f}}}<br><br>{\int <br><br>}_{-\mathrm{\infty <br><br>}}^{+\mathrm{\infty <br><br>}}<br><br><br><br>V<br><br>\text{\hspace{1em}<br><br>}<br><br>{\mathrm{<br><br>}}^{-\mathrm{ikV}}<br><br>P_{\mathrm{\alpha <br><br>}}<br><br>\left(V,r,z\right)$

where x, y and z are the orthogonal coordinates along the horizontal transverse direction, the vertical transverse direction and the longitudinal direction, respectively;

P_α

(V, r, z) are the planar images pixels values, where r is the coordinate along the transverse direction of the detector and V is the detector position along the linear orbit a;

f is the fan-beam collimator focal length; and

U_α

is the shift length of the fan-beam collimator focal line in the linear orbit a versus the origin of the axis coordinates (x=0, y=0).

10. Apparatus for imaging a target organ in a patient by SPECT, comprising:

at least one gamma camera having at least one detector/collimator combination including a gamma detector and a fan-beam collimator fixed to the gamma detector,

a bed for a patient to be examined and having a bed length;

means for defining collimator positions located respectively at the corners of a rectangle normal to the bed length to surround the bed, and including a first position over the bed, a second position under the bed, a third position on one side of the bed, and a fourth position on the side of the bed opposite the third position, the at least one collimator being positionable at all of the first, second, third, and fourth positions, and focusing to a focal line parallel to the bed length;

means for positioning the bed at such a distance from the collimator positions, that the collimator focal line is inside the patient'"'"'s body on the bed in each of the collimator positions; and

means for moving the bed in two perpendicular directions, both transverse to the bed length, to effect a horizontal movement at the first and second positions of said at least one collimator and a vertical movement at the third and fourth positions.

11. The apparatus of claim 10, wherein the means for positioning the bed comprises a system of motive members including a horizontally shifting mobile member at the foot of the bed and a jack for moving the bed in a vertical direction.

13. The apparatus of any one of claims 10 or 12, wherein the range of the relative movement between the bed and the at least one collimator is at least equal to two times the transverse size of said detector or collimator.

14. The apparatus of claim 13, wherein the range of the relative movement between the bed and the at least one collimator is approximately 100 cm.

15. The apparatus of any one of claims 10 or 12, wherein said at least one collimator has a focal length of between about 12 and 30 cm.

16. The apparatus of claim 15, wherein said at least one collimator has a focal length of about 25 cm.

17. The apparatus of any one of claims 10 or 12, comprising a single gamma detector/collimator combination movable from the first position to the second, third and fourth positions, successively.

18. The apparatus of any one of claims 10 or 12 comprising two gamma detector/collimator combinations, positioned on opposite sides of the bed, and moveable respectively from the first position to the third position, and from the second position to the fourth position.

19. The apparatus of any one of claims 10 or 12, comprising four gamma detector/collimator combinations positioned at the first, second, third and fourth positions, respectively.

20. The apparatus of claim 19, wherein the detector/collimator combinations are movable relative to the bed by means of a motive system including a rigid frame of four mutually perpendicular rails, positioned transversally to the bed length, along which the detector/collimator combinations can slide.

21. The apparatus of any one of claims 10 or 12, wherein the relative movement between the bed and the detector/collimator combinations are computer controlled by the gamma camera.

12. Apparatus for imaging a target organ in a patient by SPECT, comprising:

at least one gamma camera having at least one detector/collimator combination including a gamma detector and a fan-beam collimator fixed to the gamma detector,

a bed for a patient to be examined and having a bed surface and a bed length;

collimator positions located respectively at the corners of a rectangle normal to the bed length to surround the bed, and including a first position over the bed, a second position under the bed, a third position on one side of the bed, and a fourth position on the side of the bed opposite the third position;

the at least one collimator being positionable at all of the first, second, third, and fourth positions, and focusing to a focal line parallel to the bed length;

means for positioning the bed at such a distance from the collimator positions, that the collimator focal line is inside the patient'"'"'s body on the bed in each of the collimator positions; and

means for moving the at least one collimator in two perpendicular directions, both transverse to the bed length, to effect movement parallel to the bed surface at the first or second positions of said at least one collimator and movement perpendicular to the bed surface at the third and fourth positions.