Systems and methods for rapidly identifying useful chemicals in liquid samples
First Claim
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1. A method of modulating the activity of a selected molecular targets with a selected chemical compound, comprising:
- storing a set of chemical compounds in addressable wells in a chemical library;
programming a chemical storage and retrieval module containing said chemical compounds for the selection of a subset of said chemical compounds;
removing said subset of said addressable chemical wells from sad chemical storage module with an automated robotic retriever;
routing said selected subset of addressable chemical wells away from said chemical storage and retrieval module and toward a liquid processing apparatus in a transport pathway;
retrieving said programmed subset of said chemical compounds with said liquid processing apparatus by retrieving liquid samples from less than all of said removed subset of addressable chemical wells;
testing, in said liquid processing apparatus, said selected set of chemical compounds for modulating activity against one or more selected molecular targets;
selecting a chemical compound from among said selected set of chemical compounds that modulates that activity of at least one or more selected molecular targets; and
contacting said selected chemical compound with said selected molecular target such that the activity of said selected molecular target is modulated.
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Abstract
Substances having useful pharmacological properties are identified by candidate screeners and screening methods. The substances may be incorporated into medicaments. The substances may have modulating activity with respect to pre-defined molecular targets.
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Citations
12 Claims
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1. A method of modulating the activity of a selected molecular targets with a selected chemical compound, comprising:
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storing a set of chemical compounds in addressable wells in a chemical library;
programming a chemical storage and retrieval module containing said chemical compounds for the selection of a subset of said chemical compounds;
removing said subset of said addressable chemical wells from sad chemical storage module with an automated robotic retriever;
routing said selected subset of addressable chemical wells away from said chemical storage and retrieval module and toward a liquid processing apparatus in a transport pathway;
retrieving said programmed subset of said chemical compounds with said liquid processing apparatus by retrieving liquid samples from less than all of said removed subset of addressable chemical wells;
testing, in said liquid processing apparatus, said selected set of chemical compounds for modulating activity against one or more selected molecular targets;
selecting a chemical compound from among said selected set of chemical compounds that modulates that activity of at least one or more selected molecular targets; and
contacting said selected chemical compound with said selected molecular target such that the activity of said selected molecular target is modulated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification