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Production of membrane proteins in the milk of transgenic mammals

  • US 6,472,584 B1
  • Filed: 07/28/2000
  • Issued: 10/29/2002
  • Est. Priority Date: 10/02/1991
  • Status: Expired due to Fees
First Claim
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1. A DNA construct comprising:

  • as operably linked components, a DNA sequence encoding a cystic fibrosis transmembrane conductance regulator protein and a mammary gland specific promoter sequence wherein, upon expression of the DNA sequence, the cystic fibrosis transmembrane conductance regulator inserts into an apical membrane of a mammary cell so that said cystic fibrosis transmembrane conductance regulator protein is secreted in a milk fat globule.

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