System and method for programmably controlling electrode activation sequence in a multi-site cardiac stimulation device
First Claim
1. A method of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, for use with a multi-site cardiac stimulation device, the method comprising the steps of:
- defining a plurality of electrode configurations corresponding to available activation sequences of the electrodes;
selectively delivering a stimulus, on demand, to a cardiac chamber;
sensing a cardiac event in the cardiac chamber by using a first electrode configuration;
initiating a coupling interval for the multiple cardiac chambers;
controlling the activation sequence of the electrodes by selecting an electrode configuration based on the cardiac chamber in which the cardiac event is sensed or a stimulus delivered;
automatically acquiring a measurement of the cardiac event using the electrode configuration; and
automatically adjusting the coupling interval in response to the measurement of the cardiac event.
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Accused Products
Abstract
An implant able multi-chamber cardiac stimulation device includes flexibly programmable electrode sensing configurations, and is capable of precisely controlling the stimulation sequence between multiple sites. The stimulation device provides a plurality of connection ports that allow independent connection of each electrical lead associated with a particular stimulation site in the heart. Each connection port further provides a unique terminal for making electrical contact with only one electrode such that no two electrodes are required to be electrically coupled. Furthermore, each electrode, whether residing on a unipolar, bipolar or multipolar lead, may be selectively connected or disconnected through programmable switching circuitry that determines the electrode configurations to be used for sensing and for stimulating at each stimulation site. The stimulation device possesses unique sensing and output configurations associated with each stimulation site, such that depolarizations occurring at each stimulation site can be detected independently of events occurring at other sites within the heart, and such that each site can be stimulated independently of other sites or on a precisely timed basis triggered by events occurring at other sites. The stimulation device is further capable of uniquely programming coupling intervals for precisely controlling the activation sequence of stimulated sites. Coupling intervals are selected so as to provide optimal hemodynamic benefit to the patient.
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Citations
43 Claims
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1. A method of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, for use with a multi-site cardiac stimulation device, the method comprising the steps of:
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defining a plurality of electrode configurations corresponding to available activation sequences of the electrodes;
selectively delivering a stimulus, on demand, to a cardiac chamber;
sensing a cardiac event in the cardiac chamber by using a first electrode configuration;
initiating a coupling interval for the multiple cardiac chambers;
controlling the activation sequence of the electrodes by selecting an electrode configuration based on the cardiac chamber in which the cardiac event is sensed or a stimulus delivered;
automatically acquiring a measurement of the cardiac event using the electrode configuration; and
automatically adjusting the coupling interval in response to the measurement of the cardiac event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
when the stimulation device is stimulating a ventricle, attempting to inhibit ventricular stimulation by extending an atrial-ventricular (AV) delay;
when the stimulation device is stimulating an atrium, attempting to inhibit atrial pacing by reducing a base pacing rate;
measuring one or more baseline physiological parameters; and
modulating one or more combinations of the coupling intervals for altering the activation sequence so as to determine an activation sequence that allows optimal improvement in the current stimulation state.
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28. A multi-site cardiac stimulation device capable of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, comprising:
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a discriminator, coupled to the plurality of electrodes, that senses a cardiac signal in each of the cardiac chambers, and that identifies a cardiac chamber of origin in which the cardiac signal originates;
a pulse generator, connected to the electrodes, to selectively deliver stimulation pulses on demand to the cardiac chambers; and
timing control circuitry, connected to the electrodes, the pulse generator, and the discriminator to initiate coupling intervals for the multiple cardiac chambers based on the cardiac chamber of origin in which an intrinsic depolarization is sensed or a stimulus is delivered, for controlling a timing of the activation sequence, and the timing control circuitry further automatically adjusting the coupling intervals based on measurements acquired by the discriminator. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37)
further including a switch bank that automatically selects polarities for the plurality of stimulation electrodes.
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32. The stimulation device according to claim 30, further including a multi-port connector for connection to any one or more of uni-polar, bi-polar, or multi-polar leads.
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33. The stimulation device according to claim 32, wherein the multi-port connector includes four bipolar connection ports:
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a left ventricular connection port that couples to a left ventricular lead with terminals associated with a ventricular tip electrode, a left ventricular ring electrode, and a left atrial coil electrode;
a left atrial connection port that couples to a left atrial lead with terminals associated with a left atrial tip electrode and a left atrial ring electrode;
a right ventricular connection port that couples to a right ventricular lead with terminals associated with a right ventricular tip electrode, a right ventricular ring electrode, a right ventricular shocking coil, and a right ventricular coil electrode; and
a right atrial connection port that couples to a right atrial lead with terminals associated with a right atrial tip electrode and a right atrial ring electrode.
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34. The stimulation device according to claim 29, wherein the timing control circuitry initiates one or more coupling intervals from a right atrial stimulation pulse to any one or more of:
- a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.
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35. The stimulation device according to claim 29, wherein the sensing circuitry is adapted to further sense an occurrence of an intrinsic right atrial depolarization;
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wherein in the absence of an intrinsic right atrial depolarization, the timing control circuitry initiates one or more coupling intervals from the intrinsic right atrial depolarization to any one or more of;
a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.
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36. The stimulation device according to claim 29, wherein in the presence of an intrinsic left atrial depolarization, the sensing circuitry initiates one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of:
- a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.
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37. The stimulation device according to claim 28, wherein the plurality of electrodes include sensing electrodes;
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further including a switch bank that automatically selects polarities for the plurality of sensing electrodes.
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38. A multi-site cardiac stimulation device capable of automatically controlling an activation sequence of a plurality of electrodes that are positioned in multiple cardiac chambers, comprising:
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means for sensing a cardiac signal in each of the multiple cardiac chambers;
means for detecting a cardiac chamber of origin in which the cardiac signal originates;
means for selectively generating stimulation energy, on demand, to the multiple cardiac chambers; and
means for initiating coupling intervals for the multiple cardiac chambers based on the cardiac chamber of origin in which an intrinsic depolarization is sensed or a stimulus is delivered, for controlling a timing of the activation sequence, and for automatically adjusting the coupling intervals based on measurements acquired by the sensing means. - View Dependent Claims (39, 40, 41, 42, 43)
wherein the initiating means initiates one or more coupling intervals from a right atrial stimulation pulse to any one or more of;
a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse;
wherein in the absence of an intrinsic right atrial depolarization, the initiating means initiates one or more coupling intervals from the intrinsic right atrial depolarization to any one or more of;
a left atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse; and
wherein in the presence of an intrinsic left atrial depolarization, the initiating means initiates one or more coupling intervals from the intrinsic left atrial depolarization to any one or more of;
a right atrial stimulation pulse, a right ventricular stimulation pulse, or a left ventricular stimulation pulse.
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41. The stimulation device according to claim 38, wherein the plurality of electrodes include sensing electrodes;
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further including switching means for automatically selecting polarities for the plurality of sensing electrodes.
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42. The stimulation device according to claim 38, wherein the plurality of electrodes include stimulation electrodes;
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further including switching means for automatically selecting polarities for the plurality of stimulation electrodes.
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43. The stimulation device according to claim 38, further including a multi-port connecting means for connection to any one or more of uni-polar, bi-polar, or multi-polar leads;
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wherein the multi-port connecting means includes four bipolar connection ports;
a left ventricular connection port that couples to a left ventricular lead with terminals associated with a ventricular tip electrode, a left ventricular ring electrode, and a left atrial coil electrode;
a left atrial connection port that couples to a left atrial lead with terminals associated with a left atrial tip electrode and a left atrial ring electrode;
a right ventricular connection port that couples to a right ventricular lead with terminals associated with a right ventricular tip electrode, a right ventricular ring electrode, a right ventricular shocking coil, and a right ventricular coil electrode; and
a right atrial connection port that couples to a right atrial lead with terminals associated with a right atrial tip electrode and a right atrial ring electrode.
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Specification