Rate management during automatic capture verification

• US 6,473,649 B1
• Filed: 12/22/1999
• Issued: 10/29/2002
• Est. Priority Date: 12/22/1999
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, Gryzwa, Mark
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/470,269
• Time in Patent Office: 1,042 Days
• Field of Search: 607/27, 607/28, 607/9, 607/13, 128/901, 600/509
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: Y10S 128/901 Suppression of noise in electric signal

Abstract

An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart and suitable for use during capture verification. The device of the present invention may operate in an automatic capture verification mode, wherein an electrocardiogram signal of a patient'"'"'s heart is received and used by the device to determine whether a stimulation pulse evokes a response by the patient'"'"'s heart. The device suspends the automatic capture verification mode and/or adjust the detection threshold dependent upon detected and/or measured noise, a determined amplitude of evoked response, a determined modulation in the evoked response, or detected and/or measured artifact. Further, the sensing circuit of the rhythm management device of the present invention reduces afterpotentials that result due to delivery of the stimulation pulses.

Claims

1. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold;

(e) wherein said controller detects an evoked response of the patient'"'"'s heart from the electrocardiogram signal, determines an amplitude associated with the evoked response, and adjusts the detection threshold dependent upon the determined amplitude; and

(f) wherein said controller determines a value associated with modulation of the evoked response, wherein said value is determined from the amplitude of a detected evoked response.

2. A rhythm management device as recited in claim 1, wherein the controller adjusts the detection threshold dependant upon the value associated with modulation.

3. A rhythm management device as recited in claim 1, wherein the value associated with modulation is determined from a respiration modulation index and evoked response filter index.

4. A rhythm management device as recited in claim 1, further including a means for determining an amount associated with an artifact baseline of the electrocardiogram signal and further wherein the detection threshold is set greater than the amount associated with the artifact baseline and less than a minimum of maximum amplitudes of the evoked response over a predetermined number of beats.

5. A rhythm management device as recited in claim 1, wherein said controller detects the presence of noise in the electrocardiogram signal.

6. A rhythm management device as recited in claim 5, wherein said controller determines a value associated with an amplitude of the detected noise.

7. A rhythm management device as recited in claim 6, wherein the controller adjusts the detection threshold dependant upon the value associated with the amplitude of the detected noise.

8. A rhythm management device as recited in claim 7, further including memory means for storing the determined value associated with an amplitude of noise over a plurality of detected cardiac depolarization, wherein the controller adjusts the sensing threshold dependant upon the determined value associated with an amplitude of noise corresponding to prior detected cardiac depolarization.

9. A rhythm management device as recited in claim 1, wherein the controller within a first preset time prior to delivering a stimulation pulse analyzes the electrocardiogram signal to determine if an amplitude of a portion of the electrocardiogram signal exceeds a first sensing threshold.

10. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold; and

(e) wherein said sensing circuit includes a sense amplifier electrically connected to the electrodes and controller in a manner wherein a polarity of an amplitude of the electrocardiogram signal corresponding to an evoked response is opposite a polarity of an amplitude of the electrocardiogram signal corresponding to afterpotential.

11. A rhythm management device as recited in claim 10, wherein a positive pole of the sense amplifier is coupled to an indifferent contact and a negative pole of the sense amplifier is coupled to said electrodes.

12. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold;

(e) wherein said stimulation circuit includes a coupling capacitor arrangement that reduces afterpotentials; and

(f) wherein said coupling capacitor arrangement includes a capacitor having a capacitance less than 5 microfarads.

13. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold; and

(e) wherein the sensing circuit includes a pre-amplifier electrically coupled to the electrodes, a first high pass coupling capacitor electrically coupled between the electrodes and said pre-amplifier, and a blanking switch electrically coupled between said high pass coupling capacitor and said pre-amplifier, said sensing circuit further including a dedicated evoked response amplifier.

14. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold;

(e) wherein the sensing circuit includes an afterpotential attenuation system for attenuating afterpotentials which result due to delivery of the stimulation pulses; and

(f) wherein said afterpotential attenuation means includes a first coupling capacitor operatively coupled to a second coupling capacitor, and a switching system for selectively coupling said second coupling capacitor in series with said first coupling capacitor so as to reduce the effective capacitance of said first and second coupling capacitor.

15. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold, said sensing circuit including a sense amplifier electrically connected to the electrodes and controller in a manner wherein a polarity of an amplitude of the electrocardiogram signal corresponding to an evoked response is opposite a polarity of an amplitude of the electrocardiogram signal corresponding to afterpotential; and

(e) wherein said controller detects an evoked response of the patient'"'"'s heart from the electrocardiogram signal, determines an amplitude associated with the evoked response, and adjusts the detection threshold dependent upon the determined amplitude.

16. A rhythm management device as recited in claim 15, wherein said controller determines a value associated with modulation of the evoked response, wherein said value is determined from the amplitude of a detected evoked response.

17. A rhythm management device as recited in claim 16, wherein the controller adjusts the detection threshold dependant upon the value associated with modulation.

18. A rhythm management device as recited in claim 16, wherein the value associated with modulation is determined from a respiration modulation index and evoked response filter index.

19. A rhythm management device as recited in claim 15, further including a device for determining an amount associated with an artifact baseline of the electrocardiogram signal and further wherein the detection threshold is set greater than the amount associated with the artifact baseline and less than a minimum of maximum amplitudes of the evoked response over a predetermined number of beats.

20. A rhythm management device as recited in claim 15, wherein the controller within a first preset time prior to delivering a stimulation pulse analyzes the electrocardiogram signal to determine if an amplitude of a portion of the electrocardiogram signal exceeds a first sensing threshold.

21. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold, said sensing circuit including a sense amplifier electrically connected to the electrodes and controller in a manner wherein a polarity of an amplitude of the electrocardiogram signal corresponding to an evoked response is opposite a polarity of an amplitude of the electrocardiogram signal corresponding to afterpotential; and

(e) wherein said stimulation circuit includes a coupling capacitor arrangement that reduces afterpotentials; and

(f) wherein said coupling capacitor arrangement includes a capacitor having a capacitance less than 5 microfarads.

22. A rhythm management device as recited in claim 21, wherein the sensing circuit includes a pre-amplifier electrically coupled to the electrodes, a first high pass coupling capacitor electrically coupled between the electrodes and said pre-amplifier, and a blanking switch electrically coupled between said high pass coupling capacitor and said pre-amplifier, said sensing circuit further including a dedicated evoked response amplifier.

23. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold, said sensing circuit including a sense amplifier electrically connected to the electrodes and controller in a manner wherein a polarity of an amplitude of the electrocardiogram signal corresponding to an evoked response is opposite a polarity of an amplitude of the electrocardiogram signal corresponding to afterpotential; and

(e) wherein the sensing circuit includes an afterpotential attenuation system for attenuating afterpotentials which result due to delivery of the stimulation pulses; and

(f) wherein said afterpotential attenuation means includes a first coupling capacitor operatively coupled to a second coupling capacitor, and a switching device for selectively coupling said second coupling capacitor in series with said first coupling capacitor so as to reduce the effective capacitance of said first and second coupling capacitor.

24. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s her, said rhythm management device including:

(a) a pulse generator that generates stimulation pulses;

(b) a controller having a timing circuit, sensing circuit and stimulation circuit for controlling activation of the pulse generator and delivery of the stimulation pulses;

(c) electrodes positioned within a patient'"'"'s heart and electrically coupled to said controller, wherein electrocardiogram signals are electrically conducted to said controller, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold, said sensing circuit including a sense amplifier electrically connected to the electrodes and controller in a manner wherein a polarity of an amplitude of the electrocardiogram signal corresponding to an evoked response is opposite a polarity of an amplitude of the electrocardiogram signal corresponding to afterpotential;

(e) wherein said controller detects the presence of noise in the electrocardiogram signal; and

(f) wherein said controller determines a value associated with an amplitude of the detected noise.

25. A rhythm management device as recited in claim 24, wherein the controller adjusts the detection threshold dependant upon the value associated with the amplitude of the detected noise.

26. A rhythm management device as recited in claim 24, further including memory means for storing the determined value associated with an amplitude of noise over a plurality of detected cardiac depolarization, wherein the controller adjusts the sensing threshold dependant upon the determined value associated with an amplitude of noise corresponding to prior detected cardiac depolarization.

27. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) means for generating stimulation pulses;

(b) control means for controlling activation of said means for generating stimulation pulses and for controlling delivery of stimulation pulses, said control means having a timing circuit, sensing circuit and stimulation circuit;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said control means such that electrocardiogram signals are electrically conducted to said control means, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise, said control means determines a value associated with an amplitude of the detected noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold, wherein said control means adjusts the detection threshold dependant upon the value associated with the amplitude of the detected noise; and

(e) wherein said control means detects an evoked response of the patient'"'"'s heart from the electrocardiogram signal, determines an amplitude associated with the evoked response, and further adjusts the detection threshold dependent upon the determined amplitude.

28. A rhythm management device as recited in claim 27, wherein said control means determines a value associated with modulation of the evoked response, wherein said value is determined from the amplitude of a detected evoked response.

29. A rhythm management device as recited in claim 28, wherein the control means adjusts the detection threshold dependant upon the value associated with modulation.

30. A rhythm management device as recited in claim 28, wherein the value associated with modulation is determined from a respiration modulation index and evoked response filter index.

31. A rhythm management device as recited in claim 27, further including a means for determining an amount associated with an artifact baseline of the electrocardiogram signal and further wherein the detection threshold is set greater than the amount associated with the artifact baseline and less than a minimum of maximum amplitudes of the evoked response over a predetermined number of beats.

32. A rhythm management device as recited in claim 27, wherein said sensing circuit includes a sense amplifier electrically connected to the electrodes and control means in a manner wherein a polarity of an amplitude of the electrocardiogram signal corresponding to an evoked response is opposite a polarity of an amplitude of the electrocardiogram signal corresponding to afterpotential.

33. A rhythm management device as recited in claim 32, wherein a positive pole of the sense amplifier is coupled to an indifferent contact and a negative pole of the sense amplifier is coupled to said electrodes.

34. A rhythm management device as recited in claim 27, wherein said stimulation circuit includes a coupling capacitor arrangement that reduces afterpotentials.

35. A rhythm management device as recited in claim 34, wherein coupling capacitor arrangement includes a capacitor having a capacitance less than 5 microfarads.

36. A rhythm management device as recited in claim 27, wherein the sensing circuit includes a pre-amplifier electrically coupled to the electrodes, a first high pass coupling capacitor electrically coupled between the electrodes and said pre-amplifier, and a blanking switch electrically coupled between said high pass coupling capacitor and said pre-amplifier, said sensing circuit further including a dedicated evoked response amplifier.

37. A rhythm management device as recited in claim 27, wherein the sensing circuit includes an afterpotential attenuation means for attenuating afterpotentials which result due to delivery of the stimulation pulses.

38. A rhythm management device as recited in claim 37, wherein said afterpotential attenuation means includes a first coupling capacitor operatively coupled to a second coupling capacitor, and a switching means for selectively coupling said second coupling capacitor in series with said first coupling capacitor so as to reduce the effective capacitance of said first and second coupling capacitor.

39. A rhythm management device as recited in claim 27, wherein the control means within a first preset time prior to delivering a stimulation pulse analyzes the electrocardiogram signal to determine if an amplitude of a portion of the electrocardiogram signal exceeds a first sensing threshold.

40. An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient'"'"'s heart, said rhythm management device including:

(a) means for generating stimulation pulses;

(b) control means for controlling activation of said means for generating stimulation pulses and for controlling delivery of stimulation pulses, said control means having a timing circuit, sensing circuit and stimulation circuit;

(c) electrodes for positioning within a patient'"'"'s heart and electrically coupled to said control means such that electrocardiogram signals are electrically conducted to said control means, said electrocardiogram signal including electrical impulses corresponding to a cardiac depolarization and noise, said control means determines a value associated with an amplitude of the detected noise;

(d) said sensing circuit coupled to said timing circuit and including an adjustable detection threshold, wherein said control means adjusts the detection threshold dependant upon the value associated with the amplitude of the detected noise; and

(e) memory means for storing the determined value associated with an amplitude of noise over a plurality of detected cardiac depolarization, wherein the control means adjusts the sensing threshold dependant upon the determined value associated with an amplitude of noise corresponding to prior detected cardiac depolarization.