Methods and apparatus for determining the location of a shaft within a vessel

• US 6,474,182 B2
• Filed: 04/04/2001
• Issued: 11/05/2002
• Est. Priority Date: 11/02/1999
• Status: Expired due to Term

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Varian Incorporated (Agilent Technologies, Inc.)
• Inventors: Fernando, C. J. Anthony, Haw, Michael F., Duckett, Gregory S.
• Primary Examiner(s): NOLAND, THOMAS
• Application Number:
  US09/825,807
• Publication Number:
  US 20010052269A1
• Time in Patent Office: 580 Days
• Field of Search: 335/20, 738/155, 73/18.1, 73/17.9, 738/66, 702/150, 702/152, 702/87, 702/166, 702/94, 702/97, 356/615
• US Class Current: 73/865.5
• CPC Class Codes: B01F 27/805 wherein the stirrers or the receptacles are moved in order to bring them into operative position; Means for fixing the receptacle
• CPC Class Codes: B01F 35/20 Measuring; Control or regulation
• CPC Class Codes: G01B 21/18 for measuring depth
• CPC Class Codes: G01B 21/24 for testing alignment of axes
• CPC Class Codes: G01D 5/26 characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light
• CPC Class Codes: G01N 13/00 Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects scanning-probe techniques or apparatus G01Q
• CPC Class Codes: G01N 2013/006 Dissolution of tablets or the like
• CPC Class Codes: G01N 33/15 Medicinal preparations ; Physical properties thereof, e.g. dissolubility

Abstract

Apparatus and methods for measuring the amount by which the centerline of a shaft disposed in a vessel is offset from the central vertical axis of the vessel, and for measuring the height of such shaft above the inside bottom of the vessel. Apparatus includes a shaft centerline offset measurement device, a shaft height measurement device, and a control/display console. Each measurement device includes a transducer or optical encoder for sensing a displaced position of a biased plunger to which a code strip is mounted. The devices may be combined into a single shaft offset and height measurement device. Improved methods include calculating shaft offset based on a plurality of readings from the transducer, and applying trigonometric relationships. The apparatus and methods are particularly useful in the verification of paddle or basket shafts utilized in dissolution testing stations, so that the dissolution testing protocol complies with government agency guidelines.

Claims

1. An apparatus mountable to a shaft having a paddle or basket disposed within a vessel, the vessel having a central axis and a hemispherical end region, the apparatus adapted for measuring the distance from a distal surface of the paddle or basket to a lowermost point on the inside surface of the hemispherical end region and comprising:

(a) the housing comprising a rear face, a top face, and a coupling component for coupling the housing to the shaft, the coupling component comprising a longitudinal recess and a clip, wherein the longitudinal recess is defined by a recess wall extending inwardly toward an interior of the housing from the rear face, the longitudinal recess comprises an upper section extending downwardly from the top face, the upper section has a width greater than a width of an adjacent section of the longitudinal recess, and the clip extends outwardly from the recess wall within the upper section and comprises a pair of resilient prongs;

(b) a plunger slidably mounted to the housing, the plunger having an outer section extending outwardly beyond a wall of the housing, means for biasing the plunger outwardly, and an end portion extending transversely from the plunger beneath the housing and substantially centered about a central portion of the housing;

(c) a transducer operatively mounted to the housing and adapted to encode positions of the plunger and to produce an electrical signal proportional to a change in position resulting from displacement of the plunger; and

(d) means for transferring the signal away from the housing.

2. The apparatus according to claim 1 wherein the longitudinal recess and the prongs cooperatively define a cylindrical profile.

3. The apparatus according to claim 1 further comprising a plate mounted to the plunger and including a plurality of equally spaced lines readable by the transducer, wherein the transducer is an optical encoder disposed within the housing and the number of lines read by the transducer corresponds to a magnitude of the change in position of the plunger.

4. The apparatus according to claim 1 wherein the signal transferring means includes an electrical conduit.

5. The apparatus according to claim 1 wherein the clip defines a cross-sectional area disposed in substantial axial alignment with a cross-sectional area of the longitudinal recess.

6. The apparatus according to claim 1 comprising a device for interpreting the signal, the device disposed remotely in relation to the housing and communicating with the signal transferring means.

7. The apparatus according to claim 6 wherein the signal interpreting device comprises a display component for displaying the interpreted signal in human-readable form.

8. An apparatus mountable to an elongate member disposed within a vessel and adapted for determining the position of an end of the elongate member in relation to a lowermost point on the inside surface of the vessel, the apparatus comprising:

(a) a housing disposed along a longitudinal axis and comprising a clip device for coupling the housing to the elongate member;

(b) a plunger movably mounted to the housing and linearly displaceable inwardly toward and outwardly from the housing along a direction substantially parallel to the longitudinal axis;

(c) a transducer supported by the housing in operative relation to the plunger and adapted for sensing a displacement of the plunger and for producing an electrical signal indicative of the displacement of the plunger; and

(d) an electrical conduit communicating with the transducer for conducting the signal produced by the transducer.

9. The apparatus according to claim 8 wherein the plunger includes a plunger arm and an end portion, the plunger arm is mounted to the housing and linearly displaceable inwardly toward and outwardly from the housing along a direction substantially parallel to the longitudinal axis, and the end portion extends transversely from the plunger arm beneath the housing and is generally centered in relation to a central region of the housing.

10. The apparatus according to claim 9 wherein the housing includes a longitudinal recess formed in an outer surface of the housing, and the end portion of the plunger is generally aligned with the longitudinal recess.

11. The apparatus according to claim 8 wherein the housing includes a longitudinal recess formed in an outer surface of the housing and operatively aligned with the clip device.

12. The apparatus according to claim 8 wherein the housing comprises a top face and a longitudinal recess defined by a recess wall extending inwardly toward an interior of the housing, the longitudinal recess comprises an upper section extending downwardly from the top face, and the clip device is disposed within the upper section.

13. The apparatus according to claim 8 wherein the clip device comprises a pair of resilient prongs.

14. The apparatus according to claim 13 wherein each prong has an inside surface, and the clip device and inside surfaces of the prongs cooperatively define a cylindrical profile.

15. An apparatus mountable to an elongate member disposed within a vessel and adapted for determining the position of an end of the elongate member in relation to a lowermost point on the inside surface of the vessel, the apparatus comprising:

(a) a housing disposed along a longitudinal axis;

(b) a plunger comprising an arm and an end portion, wherein the arm is mounted to the housing and is linearly displaceable inwardly toward and outwardly from the housing along a direction substantially parallel to the longitudinal axis, and the end portion extends transversely from the arm beneath the housing and is generally centered in relation to a central region of the housing;

(c) a transducer supported by the housing in operative relation to the plunger and adapted for sensing a displacement of the plunger and for producing an electrical signal indicative of the displacement of the plunger; and

(d) an electrical conduit communicating with transducer for conducting the signal produced by the transducer.

16. The apparatus according to claim 15 wherein the housing includes a longitudinal recess formed in an outer surface of the housing, and the end portion of the plunger is generally aligned with the longitudinal recess.

17. The apparatus according to claim 16 wherein the housing includes a coupling element disposed in operative alignment with the longitudinal recess and with the end portion.

18. The apparatus according to claim 15 wherein the housing includes a coupling element, and the end portion of the plunger is generally aligned with the coupling element.

19. The apparatus according to claim 15 wherein at least a portion of the arm is disposed within the housing and extends through an opening of the housing.

20. The apparatus according to claim 15 comprising a spring element disposed in biasing engagement with the plunger.

21. The apparatus according to claim 15 comprising an electronic circuit communicating with the electrical conduit and adapted for receiving the signal conducted by the electrical conduit.

22. An apparatus mountable to an elongate member disposed within a vessel and adapted for determining the position of an end of the elongate member in relation to a lowermost point on the inside surface of the vessel, the apparatus comprising:

(a) a housing having a longitudinal axis;

(b) a plunger comprising an arm and an end portion, wherein the arm is mounted to the housing and is linearly displaceable inwardly toward and outwardly from the housing along a direction substantially parallel to the longitudinal axis, and the end portion extends transversely from the arm beneath the housing and is generally centered in relation to a central region of the housing;

(c) a transducer operatively mounted to the housing and adapted to encode positions of the plunger and to produce an electrical signal proportional to a change in position resulting from displacement of the plunger; and

(d) means for transferring the signal away from the housing; and

(e) a device for interpreting the signal, the device disposed remotely in relation to the housing and communicating with the signal transferring means.

23. The apparatus according to claim 22 wherein the housing comprises a clip for coupling the housing to the elongate member.

24. The apparatus according to claim 23 wherein the housing comprises a longitudinal recess, and the clip is operatively aligned with the longitudinal recess.

25. The apparatus according to claim 23 wherein the clip comprises a pair of resilient prongs.

26. The apparatus according to claim 22 wherein the arm is slidably disposed within the housing and extends outwardly through a hole in the wall of the housing.

27. The apparatus according to claim 22 wherein the signal transferring means comprises an electrical conduit.

28. The apparatus according to claim 22 wherein the signal interpreting device comprises a display component for displaying the interpreted signal in human-readable form.