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2′ Modified oligonucleotides

  • US 6,476,205 B1
  • Filed: 08/10/1998
  • Issued: 11/05/2002
  • Est. Priority Date: 10/24/1989
  • Status: Expired due to Fees
First Claim
Patent Images

1. An oligonucleotide having the formula:

  • embedded imageor a salt thereof, wherein;

    each B independently is a protected or unprotected purine or pyrimidine base in the β

    -anomeric configuration;

    W3 and W4 are each independently H, PO3

    2
    , a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate —

    OH results in Z;

    n is an integer of 1-200;

    each Z is independently is P(O)O, P(O)S or P(O)N(R)2 provided at least one Z is not P(O)O;

    each R is independently H or alkyl (C1-6);

    each A is OCH3, H, OH, O—

    Pr wherein Pr is a protecting group, or X—

    Y wherein;

    X is O; and

    Y is substituted or unsubstituted alkyl (C2-20) or substituted or unsubstituted alkenyl (C2-20), wherein the substituents are a halogen, OH, NH2, SH, —

    O—

    , —

    CH2CONH2, —

    CH2COOCH2CH3, or CH2CONHCH2NH2; and

    at least one A is OCH3.

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