Control of pacing rate in mode switching implantable medical devices

• US 6,477,420 B1
• Filed: 04/27/2001
• Issued: 11/05/2002
• Est. Priority Date: 04/27/2001
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Dunham, David, Struble, Chester L.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/842,879
• Publication Number:
  US 20020188328A1
• Time in Patent Office: 557 Days
• Field of Search: 607/9, 607/14, 607/5
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

An implantable medical device and method of pacing provide for switching from a first pacing mode to second pacing mode upon detection of a period of accelerated atrial arrhythmia. Generally, the second pacing mode has an associated predetermined lower pacing rate. At least initially, upon switching from the first pacing mode to the second pacing mode, the predetermined lower pacing rate is adjusted to an elevated adjusted lower rate. Further, this elevated adjusted lower rate may then be decelerated towards a programmed basic pacing rate during a deceleration period. Generally, the programmed basic pacing rate is elevated relative to the predetermined lower pacing rate.

Claims

1. An implantable medical device method of pacing, the method comprising:

detecting a period of accelerated atrial arrhythmias;

switching from a first pacing mode to a second pacing mode upon detection of the period of accelerated atrial arrhythmias, wherein the first pacing mode paces at least one ventricle based on sensed atrial activity, and further wherein the second pacing mode paces the at least one ventricle based on sensed ventricular activity at a predetermined lower rate with such pacing inhibited based on intrinsic ventricular activity; and

at least initially, upon switching from the first pacing mode to the second pacing mode, adjusting the lower rate to an elevated adjusted lower rate such that pacing of the at least one ventricle is not inhibited based on intrinsic ventricular activity.

2. The method of claim 1, wherein adjusting the lower rate to an elevated adjusted lower rate comprises adjusting the lower rate to an elevated adjusted lower rate based on R-R intervals measured during a ventricular response detection time window associated with switching from the first pacing mode to the second pacing mode.

3. The method of claim 2, wherein adjusting the lower rate to the elevated adjusted lower rate comprises:

measuring one or more R-R intervals during the ventricular response detection time window;

detecting at least the fastest R-R interval occurring during the ventricular response detection time window; and

adjusting the lower rate to the elevated adjusted lower rate based on at least the fastest R-R interval measured during the ventricular response detection time window.

4. The method of claim 2, wherein adjusting the lower rate to the elevated adjusted lower rate comprises:

determining the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window; and

limiting the elevated adjusted lower rate based on a programmed maximum pacing rate.

5. The method of claim 2, wherein adjusting the lower rate to the elevated adjusted lower rate comprises:

determining the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window;

comparing the elevated adjusted lower rate to an activity sensor indicated pacing rate; and

using either the elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

6. The method of claim 1, wherein the method further comprises decelerating from the elevated adjusted lower rate towards a predetermined basic pacing rate that is as fast or faster than the predetermined lower rate.

7. The method of claim 6, wherein decelerating from the elevated adjusted lower rate towards the predetermined basic pacing rate comprises:

decelerating from the elevated adjusted lower rate towards the predetermined basic pacing rate during a deceleration period;

monitoring ventricular activity to detect any intrinsic ventricular events during the deceleration period; and

readjusting the elevated adjusted lower rate upon detection of an intrinsic ventricular event during the deceleration period and decelerating the readjusted elevated lower rate during a reinitiated deceleration period.

8. The method of claim 6, wherein decelerating from the elevated adjusted lower rate towards the predetermined basic pacing rate further comprises continuing deceleration to the predetermined basic pacing rate if no intrinsic ventricular events are detected during the deceleration period and thereafter continuing to use the predetermined basic pacing rate until either an intrinsic ventricular event is detected and a readjusted elevated lower rate is reset for deceleration during another deceleration period or operation is switched from the second pacing mode back to the first pacing mode.

9. The method of claim 6, wherein decelerating from the elevated adjusted lower rate towards the predetermined basic pacing rate comprises:

comparing the decelerating elevated adjusted lower rate to an activity sensor indicated pacing rate; and

using either the decelerating elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

10. The method of claim 1, wherein switching from the first pacing mode to the second pacing mode comprises switching from a DDD, DDDR, VDD, or VDDR pacing mode to a DDI, DDIR, VVI, or VVIR pacing mode, respectively.

11. The method of claim 1, wherein t he implantable medical device comprises a bi-ventricular pacing apparatus, a dual chamber pacing apparatus, and a pacemaker/cardioverter/defibrillator.

12. An implantable medical device method of pacing, the method comprising:

switching from a DDD, DDDR, VDD, or VDDR first pacing mode to a DDI, DDIR, VVI, or VVIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia, wherein the second pacing mode has an associated predetermined lower pacing rate;

at least initially, upon switching from the first pacing mode to the second pacing mode, adjusting the predetermined lower pacing rate to an elevated adjusted lower rate; and

decelerating from the elevated adjusted lower rate towards a programmed basic pacing rate during a deceleration period, wherein the programmed basic pacing rate is as fast or faster than the predetermined lower pacing rate.

13. The method of claim 12, wherein adjusting the predetermined lower pacing rate associated with the second pacing mode to the elevated adjusted lower rate comprises adjusting the predetermined lower pacing rate to an elevated adjusted lower rate based on R-R intervals measured during a ventricular response detection time window associated with switching from the first pacing mode to the second pacing mode.

14. The method of claim 13, wherein adjusting the predetermined lower pacing rate to the elevated adjusted lower rate comprises:

measuring one or more R-R intervals during the ventricular response detection time window;

detecting at least the fastest R-R interval occurring during the ventricular response detection time window; and

adjusting the predetermined lower pacing rate to the elevated adjusted lower rate based on at least the fastest R-R interval measured during the ventricular response detection time window.

15. The method of claim 13, wherein adjusting the predetermined lower pacing rate to the elevated adjusted lower rate comprises:

determining the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window; and

limiting the elevated adjusted lower rate based on a programmed maximum pacing rate.

16. The method of claim 12, wherein switching from the DDD, DDDR, VDD, or VDDR first pacing mode to the DDI, DDIR, VVI, or VVIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia comprises switching from a DDDR or VDDR first pacing mode to a DDIR or VVIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia, and further wherein adjusting the predetermined lower pacing rate associated with the second pacing mode to an elevated adjusted lower rate comprises:

determining the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window;

comparing the elevated adjusted lower rate to an activity sensor indicated pacing rate; and

using either the elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

17. The method of claim 12, wherein decelerating from the elevated adjusted lower rate towards the programmed basic pacing rate comprises:

monitoring to sense any intrinsic ventricular activity during the deceleration period; and

readjusting the elevated adjusted lower rate upon detection of intrinsic ventricular activity during the deceleration period and decelerating the readjusted elevated lower rate during a reinitiated deceleration period.

18. The method of claim 12, wherein decelerating from the elevated adjusted lower rate towards the programmed basic pacing rate further comprises continuing deceleration to the programmed basic pacing rate if no intrinsic ventricular activity is detected during the deceleration period and thereafter continuing use of the programmed basic pacing rate until either intrinsic ventricular activity is detected and a new readjusted elevated lower rate is reset for deceleration during another deceleration period or operation is switched from the second pacing mode back to the first pacing mode.

19. The method of claim 12, wherein switching from the DDD, DDDR, VDD, or VDDR first pacing mode to the DDI, DDIR, VVI, or WIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia comprises switching from a DDDR or VDDR first pacing mode to a DDIR or VVIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia, and further wherein decelerating from the elevated adjusted lower rate towards the programmed basic pacing rate comprises:

comparing the decelerating elevated adjusted lower rate to an activity sensor indicated pacing rate; and

using either the decelerating elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

20. The method of claim 12, wherein the implantable medical device comprises a bi-ventricular pacing apparatus, a dual chamber pacing apparatus, and a pacemaker/cardioverter/defibrillator.

21. An implantable medical device comprising:

pacing generator circuitry operable to generate pacing pulses at one or more pacing rates during at least first and second pacing modes, wherein the first pacing mode paces at least one ventricle based on sensed atrial activity, and further wherein the second pacing mode paces the at least one ventricle based on sensed ventricular activity at a predetermined lower rate with such pacing inhibited based on intrinsic ventricular activity;

sensing circuitry operable to sense atrial and ventricular activity; and

a pacing controller operable to switch from the first pacing mode to the second pacing mode upon detecting a period of accelerated atrial arrhythmias based on information from the sensing circuitry, wherein the pacing controller is further operable to at least initially, upon switching from the first pacing mode to the second pacing mode, adjust the predetermined lower rate to an elevated adjusted lower rate such that pacing of the at least one ventricle is not inhibited based on detected intrinsic ventricular activity.

22. The device of claim 21, further wherein the pacing controller is operable to adjust the predetermined lower rate to the elevated adjusted lower rate based on R-R intervals measured during a ventricular response detection time window associated with switching from the first pacing mode to the second pacing mode.

23. The device of claim 22, further wherein the pacing controller is operable to:

measure one or more R-R intervals during the ventricular response detection time window based on information from the sensing circuitry;

determine at least the fastest R-R interval occurring during the ventricular response detection time window; and

adjust the predetermined lower rate to the elevated adjusted lower rate based on at least the fastest R-R interval measured during the ventricular response detection time window.

24. The device of claim 22, further wherein the pacing controller is operable to:

determine the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window; and

limit the elevated adjusted lower rate based on a programmed maximum pacing rate.

25. The device of claim 24, further wherein the pacing controller is operable to:

determine the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window;

compare the elevated adjusted basic pacing rate to an activity sensor indicated pacing rate; and

control the pacing rate by using either the elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

26. The device of claim 21, wherein the pacing controller is further operable to decelerate the elevated adjusted lower rate towards a predetermined basic pacing rate that is as fast or faster than the predetermined lower rate.

27. The device of claim 26, further wherein the pacing controller is operable to:

control deceleration from the elevated adjusted lower rate towards the predetermined basic pacing rate during a deceleration period; and

readjust the elevated adjusted lower rate during the deceleration period based on intrinsic ventricular activity sensed by the sensing circuitry and control deceleration of the readjusted elevated lower rate during a reinitiated deceleration period.

28. The device of claim 26, wherein the pacing controller is further operable to continue deceleration to the predetermined basic pacing rate if no intrinsic ventricular activity is sensed during the deceleration window and thereafter continue to use the predetermined basic pacing rate until either intrinsic ventricular activity is sensed and a new readjusted elevated lower rate is reset for deceleration during another deceleration period or operation is switched from the second pacing mode back to the first pacing mode.

29. The device of claim 26, further wherein the pacing controller is operable to:

compare the decelerating elevated adjusted lower rate to an activity sensor indicated pacing rate; and

use either the decelerating elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

30. The device of claim 21, wherein the pacing controller is operable to switch from a DDD, DDDR, VDD, or VDDR first pacing mode to a DDI, DDIR, VVI, or VVIR second pacing mode, respectively.

31. The device of claim 21, wherein the implantable medical device comprises a bi-ventricular pacing apparatus, a dual chamber pacing apparatus, and a pacemaker/cardioverter/defibrillator.

32. An implantable medical device comprising:

pacing generator circuitry operable to generate pacing pulses at one or more pacing rates during at least first and second pacing modes, wherein the first pacing mode comprises a DDD, DDDR, VDD, or VDDR pacing mode and wherein the second pacing mode comprises a DDI, DDIR, VVI, or VVIR pacing mode, and further wherein the DDI, DDIR, VVI, or VVIR second pacing mode has an associated programmed lower pacing rate;

sensing circuitry operable to sense atrial and ventricular activity; and

a pacing controller operable to switch from the DDD, DDDR, VDD, or VDDR first pacing mode to the DDI, DDIR, VVI, or VVIR second pacing mode, respectively, upon detecting a period of accelerated atrial arrhythmias based on information from the sensing circuitry, wherein the pacing controller is further operable to at least initially, upon switching from the first pacing mode to the second pacing mode, adjust the programmed lower pacing rate to an elevated adjusted lower rate, and further wherein the pacing controller is operable to decelerate the elevated adjusted lower rate towards a predetermined basic pacing rate that is as fast or faster than the programmed lower pacing rate during a deceleration period.

33. The device of claim 32, further wherein the pacing controller is operable to adjust the programmed lower pacing rate to an elevated adjusted lower rate based on R-R intervals measured during a ventricular response detection time window associated with switching from the first pacing mode to the second pacing mode.

34. The device of claim 33, wherein the pacing controller is further operable to:

measure one or more R-R intervals during the ventricular response detection time window based on information from the sensing circuitry;

determine at least the fastest R-R interval occurring during the ventricular response detection time window; and

adjust the programmed lower pacing rate to the elevated adjusted lower rate based on at least the fastest R-R interval measured during the ventricular response detection time window.

35. The device of claim 32, further wherein the pacing controller is operable to:

determine the elevated adjusted lower rate based on R-R intervals measured during the ventricular response detection time window; and

limit the elevated adjusted lower rate based on a programmed maximum pacing rate.

36. The device of claim 32, wherein the pacing controller is operable to switch from a DDDR or VDDR first pacing mode to a DDIR or VVIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia, and further wherein the pacing controller is further operable to:

determine the elevated adjusted lower rate based on R-R intervals measured during a ventricular response detection time window;

compare the elevated adjusted lower rate to an activity sensor indicated pacing rate; and

use either the elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

37. The device of claim 32, wherein the pacing controller is further operable to readjust the elevated adjusted lower rate during the deceleration period based on intrinsic ventricular activity sensed by the sensing circuitry and control deceleration of the readjusted elevated lower rate during a reinitiated deceleration period.

38. The device of claim 32, further wherein the pacing controller is operable to continue deceleration towards the programmed basic pacing rate if no intrinsic ventricular activity is sensed during the deceleration period and thereafter continue use of the programmed basic pacing rate until either intrinsic ventricular activity is sensed and a new readjusted elevated lower rate is reset for deceleration during another deceleration period or operation is switched from the second pacing mode back to the first pacing mode.

39. The device of claim 32, wherein the pacing controller is further operable to switch from a DDDR or VDDR first pacing mode to a DDIR or VVIR second pacing mode, respectively, upon detection of a period of accelerated atrial arrhythmia, and further wherein the pacing controller is operable to:

compare the decelerating elevated adjusted lower rate to an activity sensor indicated pacing rate; and

use either the decelerating elevated adjusted lower rate or the activity sensor indicated pacing rate based on the comparison.

40. The device of claim 32, wherein the implantable medical device comprises a bi-ventricular pacing apparatus, a dual chamber pacing apparatus, and a pacemaker/cardioverter/defibrillator.