Sensor and sensor assembly for detecting a target gas in a breath sample
First Claim
1. A sensor assembly for use in determining the presence of a target gas within a breath sample comprising:
- a sensor body having a chamber disposed therein, the chamber extending between body portions that are optically transparent, the chamber being in gas flow communication with a passage for passing a collected breath sample therethrough;
a sensor material disposed within the chamber, the sensor material being reactive with a target gas in a collected breath sample to produce a change in sensor optical properties, the sensor material comprising one or more ingredients selected from each of the following groups consisting of;
Group 1;
sodium hydroxide, potassium hydroxide, sodium carbonate, and mixtures thereof;
Group 2;
alcohols, dimethyl sulfoxide, tetrahydrofuran, dimethyl formamide, chloroform, and mixtures thereof; and
Group 3;
salicylaldehyde and its derivatives, vanilla and its derivatives, benzaldehyde and its derivatives, and mixtures thereof.
1 Assignment
0 Petitions
Accused Products
Abstract
Sensor and sensor assemblies generally comprises a sensor body having a chamber disposed therein for accommodating a sensor reagent or material. The chamber is defined within the body between optically transparent body portions. The chamber is in gas flow communication with a passage used for passing a collected breath to the sensor material. A liquid or solid sensor material is disposed within the chamber and is designed to change in optical properties upon exposure to a target gas within the collected breath sample by reaction therewith. A gas permeable membrane can be disposed over the chamber opening to retain the sensor material, in the event it is liquid, and to permit the diffusion of gas from the collected breath sample to the sensor material. The sensor assembly is used with a photon source that emits photons, within a selected wavelength band, onto the chamber and sensor material, and a photon collector that is used to receive photons that exit the chamber. The photon source and photon collector can be part of the sensor assembly or can be part of a breath diagnostic assembly, of which the sensor assembly is a removable member. An optical reading means can be used to determine the change or rate of change in the optical properties, e.g., photon adsorption, of the sensor material after it is exposed to the collected breath sample. The measured change in optical properties can then be used with other gathered information, such as carbon dioxide level, to determine the level of target gas within the collected breath sample.
65 Citations
29 Claims
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1. A sensor assembly for use in determining the presence of a target gas within a breath sample comprising:
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a sensor body having a chamber disposed therein, the chamber extending between body portions that are optically transparent, the chamber being in gas flow communication with a passage for passing a collected breath sample therethrough;
a sensor material disposed within the chamber, the sensor material being reactive with a target gas in a collected breath sample to produce a change in sensor optical properties, the sensor material comprising one or more ingredients selected from each of the following groups consisting of;
Group 1;
sodium hydroxide, potassium hydroxide, sodium carbonate, and mixtures thereof;
Group 2;
alcohols, dimethyl sulfoxide, tetrahydrofuran, dimethyl formamide, chloroform, and mixtures thereof; and
Group 3;
salicylaldehyde and its derivatives, vanilla and its derivatives, benzaldehyde and its derivatives, and mixtures thereof.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
in the range of from 1 to 25 percent by weight of one or more Group 1 ingredients;
in the range of from 5 to 70 percent by weight of one or more Group 2 ingredients;
in the range of from 0.3 to 8 percent by weight of one or more Group 3 ingredients; and
up to about 1 percent by weight of one or more Group 4 ingredients.
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4. The assembly as recited in claim 1 wherein the sensor material is a liquid under operating conditions and the body chamber includes an opening to the passage, and wherein the sensor assembly further comprises means disposed over the chamber opening and interposed between the sensor material and the passage to both retain the liquid sensor material within the chamber and permit the diffusion of gas from the passage to the sensor material.
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5. The assembly as recited in claim 1 wherein the sensor material is in solid form under operating conditions and is disposed onto a porous substrate.
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6. The assembly as recited in claim 5 wherein the porous substrate is the body, wherein the body has a substantially tubular form and the chamber extends axially therethrough, and wherein the sensor material is disposed along an inside diameter wall surface of the body.
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7. The assembly as recited in claim 1 further comprising:
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a photon source positioned adjacent an optically transparent body portion for directing photons into the chamber and into the sensor material; and
a photon collector positioned adjacent the same or different optically transparent body portion as the photon source for receiving photons from the chamber and the sensor material.
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8. The assembly as recited in claim 7 wherein the photon source and photon collector are positioned adjacent the same optically transparent body portion, and comprising a reflector positioned at an optically transparent body portion opposite from the photon source and photon collector.
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9. The assembly as recited in claim 1 further comprising means for measuring the change in optical properties of the sensor material when exposed to the target gas, and for determining the level of target gas within the breath sample from the measured change in optical properties.
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10. The assembly as recited in claim 1 further comprising:
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means for collecting a breath sample;
means for storing the collected breath sample; and
means for controlling the release of the collected breath sample from the means for storing to the passage for contact with the sensor material.
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11. A sensor assembly for measuring the concentration of a target gas in a human breath sample comprising:
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a sensor body having a chamber disposed therein, the chamber extending between body portions that are optically transparent and having an opening to a surrounding environment outside of the body;
a sensor material disposed within the chamber, the sensor material being liquid under operating conditions and being reactive with a target gas to produce a change in sensor material optical properties;
a gas permeable membrane disposed over the chamber opening and interposed between the sensor material and the environment outside of the body;
means for collecting and passing a sample of a human breath to the membrane for passing to sensor material;
a photon source disposed adjacent the body for emitting photons into the chamber and into the sensor material;
a photon collector disposed adjacent the body for receiving photons exiting the chamber. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
Group 1;
sodium hydroxide, potassium hydroxide, sodium carbonate, and mixtures thereof;
Group 2;
alcohols, dimethyl sulfoxide, tetrahydrofuran, dimethyl formamide, chloroform, and mixtures thereof; and
Group 3;
salicylaldehyde and its derivatives, vanilla and its derivatives, benzaldehyde and its derivatives, and mixtures thereof.
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13. The assembly as recited in claim 12 wherein the sensor material further comprises at least one supermolecular compelling molecule from Group 4 consisting of molecules of the cyclodextrin family, crown ethers, and mixtures thereof.
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14. The assembly as recited in claim 13 wherein the sensor material comprises:
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in the range of from 1 to 25 percent by weight of one or more Group 1 ingredients;
in the range of from 5 to 70 percent by weight of one or more Group 2 ingredients;
in the range of from 0.3 to 8 percent by weight of one or more Group 3 ingredients; and
up to about 1 percent by weight of one or more Group 4 ingredients.
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15. The assembly as recited in claim 11 wherein the body is substantially tubular and the chamber extends radially into the body from at least one wall surface, and wherein the photon source and photon detector are each positioned adjacent an opposite axial end of the body that is optically transparent.
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16. The assembly as recited in claim 11 wherein the body is substantially tubular and the chamber extends radially into the body from at least one wall surface, and wherein the photon source and photon detector are each positioned adjacent one axial end of the body that is optically transparent, and wherein a reflector is positioned adjacent an opposite axial end of the body that is optically transparent.
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17. The assembly as recited in claim 11 further comprising a optical waveguide positioned adjacent the body for receiving photons exiting the body and passing the received photons back into the body and the sensor material.
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18. The assembly as recited in claim 11 Further comprising:
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means for measuring the rate of change of optical properties of the sensor material when exposed to the target gas in the collected breath sample;
means for measuring the level of carbon dioxide in the collected breath sample; and
means for determining the level of target gas with the collected breath sample.
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19. The assembly as recited in claim 18 wherein the means for measuring comprises a circuit to measure and analyze the rate of change of optical properties of the sensor material, and wherein the means for determining comprises a microprocessor to calculate the amount of the target gas in the collected breath sample by measuring the level of carbon dioxide in the collected sample to determine the amount of end-expired breath capture.
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20. A sensor assembly for measuring the concentration of a target gas in a human breath sample comprising:
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a sensor body having a chamber disposed therein, the chamber extending between body portions that are optically transparent and having an opening to a surrounding environment outside of the body;
a liquid sensor material disposed within the chamber, the sensor material being reactive with a target gas to produce a chemoptical response, the sensor material comprising one or more ingredients selected from each of the following groups consisting of;
Group 1;
sodium hydroxide, potassium hydroxide, sodium carbonate, and mixtures thereof;
Group 2;
alcohols, dimethyl sulfoxide, tetrahydrofuran, dimethyl formamide, chloroform, and mixtures thereof; and
Group 3;
salicylaldehyde and its derivatives, vanilla and its derivatives, benzaldehyde and its derivatives, and mixtures thereof; and
optionally including one or more ingredients selected fromGroup 4;
consisting of molecules of the cyclodextrin family, crown ethers, and mixtures thereof;
a gas permeable membrane disposed over the chamber opening and interposed between the sensor material and the environment outside of the body;
means for collecting and passing a sample of a human breath to the membrane for passing to sensor material;
a photon source disposed adjacent the body for emitting photons into the chamber and into the sensor material;
a photon collector disposed adjacent the body for receiving photons exiting the chamber; and
means for measuring the rate of change of sensor material optical properties when exposed to the collected breath sample. - View Dependent Claims (21)
in the range of from 1 to 25 percent by weight of one or more Group 1 ingredients;
in the range of from 5 to 70 percent by weight of one or more Group 2 ingredients;
in the range of from 0.3 to 8 percent by weight of one or more Group 3 ingredients;
up to about 1 percent by weight of one or more Group 4 ingredients.
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22. A method for determining the level of target gas in a collected breath sample comprising the steps of:
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collecting a sample of breath;
passing the collected breath sample to a sensor assembly comprising a sensor material disposed within a body having one or more optically transparent portions, wherein the sensor material is disposed within the body so that it is exposed to the breath sample passed to the sensor assembly;
directing photons into the body and sensor material by a photon source;
receiving photons exiting the body and sensor by a photon collector;
measuring a change in sensor material optical properties when exposed to the collected breath sample; and
determining the level of target gas within the collected breath sample from the measured optical properties;
wherein during the passing step the sensor material undergoes a chemical reaction upon exposure to the target gas that produces an optical change, wherein the sensor material is a liquid at operating conditions and comprises one or more ingredients selected from each of the following groups consisting of;
Group 1;
sodium hydroxide, potassium hydroxide, sodium carbonate, and mixtures thereof;
Group 2;
alcohols, dimethyl sulfoxide, tetrahydrofuran, dimethyl formamide, chloroform, and mixtures thereof; and
Group 3;
salicylaldehyde and its derivatives, vanilla and its derivatives, benzaldehyde and its derivatives, and mixtures thereof.- View Dependent Claims (23, 24, 25, 26, 27, 28, 29)
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Specification