Antimicrobial artificial nail composition and methods for preparing and using same

• US 6,479,039 B1
• Filed: 07/13/1999
• Issued: 11/12/2002
• Est. Priority Date: 07/13/1999
• Status: Expired due to Term

• Current Assignee: Pacific World Corporation (PWC Holding Corp.)
• Original Assignee: Woodward Laboratories, Inc.
• Inventors: Dyer, David, Gerenraich, Kenneth B.
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US09/352,292
• Time in Patent Office: 1,218 Days
• Field of Search: 424/405, 424/61, 424/407, 424/409, 424/443, 524/533
• US Class Current: 424/61
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations

Abstract

A composition for forming an antimicrobial artificial nail, a method for preparing the same, and a method for treating a microbial infection of a nail plate are provided. The composition comprises a binder component; a filler component which polymerizes to form an acrylic matrix subsequent to contact with the binder component; and an antimicrobial agent available for diffusion from the acrylic matrix.

Claims

1. A composition for forming an antimicrobial artificial nail comprising, in weight percent:

between about 20% and about 50% of a binder component comprising a methacrylate monomer;

between about 50% and about 80% of a filler component comprising a polymer and a catalysis initiator, wherein said filler component and said binder component form an acrylic matrix when reacted; and

between about 0.01% and about 5% of an antimicrobial agent available for diffusion from said acrylic matrix.

2. The composition of claim 1 wherein the antimicrobial agent is incorporated in to the binder component.

3. The composition of claim 1 wherein the antimicrobial agent is incorporated into the filler component.

4. The composition of claim 1 wherein the antimicrobial agent comprises a quaternary amine.

5. The composition of claim 4 wherein the antimicrobial agent is selected from the group consisting of monoalkyl-trimethyl ammonium salts, dialkyl ammonium salts, heteroaromatic ammonium salts, polysubstituted quaternary ammonium salts, bis-quaternary ammonium salts, and polymeric quaternary ammonium salts.

6. The composition of claim 5 wherein the antimicrobial agent comprises benzalkonium chloride, a homologue of benzalkonium chloride, or a mixture thereof.

7. The composition of claim 6 wherein the antimicrobial agent comprises N,N-dimethyl-decylammonium chloride, N,N-dimethyl-undecylammonium chloride, N,N-dimethyl-dodecylammonium chloride, N,N-dimethyl-tridecylammonium chloride, N,N-dimethyl-tetradecylammonium chloride, N,N-dimethyl-pentadecylammonium chloride, N,N-dimethyl-hexadecylammonium chloride, N,N-dimethyl-heptadecylammonium chloride, or a mixture thereof.

8. The composition of claim 1 wherein the antimicrobial agent comprises phenols, halogenated phenols, bis-phenols, alkyl-substituted phenols, cresols, resorcinols, or a mixture thereof.

9. The composition of claim 1 wherein the antimicrobial agent comprises a biguanide.

10. The composition of claim 1 wherein the antimicrobial agent comprises a furan derivative.

11. The composition of claim 1 wherein the antimicrobial agent comprises an antimicrobial dye.

12. The composition of claim 1 wherein the antimicrobial agent comprises a tertiary amine catalyst.

13. The composition of claim 1 wherein the antimicrobial agent comprises an organic peroxide.

17. The composition of claim 1 wherein the antimicrobial agent is incorporated into the binder component.

18. The composition of claim 1 wherein the antimicrobial agent is incorporated into the filler component.

19. The composition of claim 1 wherein the antimicrobial agent comprises a quaternary amine.

20. The composition of claim 19 wherein the antimicrobial agent is selected from the group consisting of monoalkyl-trimethyl ammonium salts, dialkyl ammonium salts, heteroaromatic ammonium salts, polysubstituted quaternary ammonium salts, bis-quaternary ammonium salts, and polymeric quaternary ammonium salts.

21. The composition of claim 20 wherein the antimicrobial agent comprises benzalkonium chloride, a homologue of benzalkonium chloride, or a mixture thereof.

22. The composition of claim 1 wherein the antimicrobial agent comprises an antimicrobial dye.

23. The composition of claim 1 wherein the antimicrobial agent comprises a tertiary amine catalyst.

24. The composition of claim 1 wherein the antimicrobial agent comprises an organic peroxide.

14. A method for forming an antimicrobial artificial nail comprising the steps of:

a. mixing a binder component comprising a methacrylate binder, a filler component comprising a finely-divided polymer and a catalysis initiator, and an antimicrobial agent to form a pre-nail mixture;

b. forming the pre-nail mixture into a predetermined shape; and

c. allowing the pre-nail mixture to polymerize to form a matrix wherein the antimicrobial agent is available for diffusion from the matrix.

15. A method for treating a microbial infection of a nail plate comprising the step of applying to the nail plate an artificial nail formed from a composition:

a. a binder component comprising a methacrylate binder;

b. a filler component comprising a finely-divided polymer and a catalysis initiator, wherein the filler component polymerizes to form a matrix subsequent to contact with the binder component; and

c. an antimicrobial agent available for diffusion from the matrix.

16. An artificial nail formed by a process comprising the steps of:

a. mixing a binder component comprising a methacrylate binder, a filler component comprising a finely-divided polymer and a catalysis initiator, and an antimicrobial agent to form a pre-nail mixture;

b. forming the pre-nail mixture into a predetermined shape; and

c. allowing the pre-nail mixture to polymerize to form a matrix wherein the antimicrobial agent is available for diffusion from the matrix.