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Culturing different cell populations on a decellularized natural biostructure for organ reconstruction

  • US 6,479,064 B1
  • Filed: 12/29/1999
  • Issued: 11/12/2002
  • Est. Priority Date: 12/29/1999
  • Status: Expired due to Term
First Claim
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1. An artificial organ construct comprising:

  • a three-dimensional scaffold of connective tissue formed by decellularizing a natural biostructure to remove cellular content, which has been perfused with a first population of isolated and cultured endothelial cells, such that the endothelial cells attach to the three-dimensional scaffold to produce an endothelial tissue layer comprising a vascular system, and at least one second population of cultured cells that is different from the population of cultured endothelial cells, such that the second cell population attaches to the endothelial tissue layer comprising a vascular system and differentiates into a neomorphic organ structure.

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