Device having a microporous membrane lined deformable wall for implanting cell cultures
First Claim
1. A device for implanting a cell culture in a host, comprising:
- a. a biocompatible deformable body whose shape can be altered by applying stress or pressure, said body comprising a continuous wall constructed from a mesh material, b. a biocompatible microporoas membrane lining a surface of the deformable body, wherein the continuous wall and biocompatible microporous membrane define an enclosed three-dimensional cavity; and
c. a sealable port adapted and configured for adding a cell culture to the enclosed three-dimensional cavity, wherein the sealable port is formed of a material that is capable of resealing after being punctured with a needle.
1 Assignment
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Accused Products
Abstract
A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the body which is preferably rounded can be altered by applying stress or pressure, The body comprises a continuous wall constructed of a mesh material, and the membrane lines a surface of the body. The wall and membrane define an enclosed three-dimensional cavity for containing a cell culture. Openings of the membrane allow for passage of therapeutic substances produced by the cells and nutrients or biomolecules produced by host. The sealable port is configured for adding a cell culture to the cavity, and is formed of a material that is capable of resealing after being punctured with a needle. Because the device is deformable, it can be compressed and placed in an implantation site where it expands to conform to contours of tissue surrounding the site. The mesh may be formed of spring tempered stainless steal or memory metals. The membrane may be coated with a material such as extracellular matrix material that facilitates attachment of cells such as by ionic or covalent bonding. An external surface of the device may be coated with an angiogenic material.
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Citations
24 Claims
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1. A device for implanting a cell culture in a host, comprising:
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a. a biocompatible deformable body whose shape can be altered by applying stress or pressure, said body comprising a continuous wall constructed from a mesh material, b. a biocompatible microporoas membrane lining a surface of the deformable body, wherein the continuous wall and biocompatible microporous membrane define an enclosed three-dimensional cavity; and
c. a sealable port adapted and configured for adding a cell culture to the enclosed three-dimensional cavity, wherein the sealable port is formed of a material that is capable of resealing after being punctured with a needle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification