Human xenografts for microbicide testing and anatomical modeling
First Claim
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1. A method, for preparing a human tissue xenograft comprising:
- a) providing isolated human vaginal tissue;
b) configuring said human vaginal tissue so as to create a rolled vaginal graft comprising a lumen; and
c) engrafting said rolled vaginal graph within an immunocompromised non-human host to create an engrafted vaginal xenograft comprising a lumen.
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Abstract
A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated human vaginal xenografts in order to screen a wide range of candidate antimicrobials administered topically or systemically.
55 Citations
16 Claims
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1. A method, for preparing a human tissue xenograft comprising:
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a) providing isolated human vaginal tissue;
b) configuring said human vaginal tissue so as to create a rolled vaginal graft comprising a lumen; and
c) engrafting said rolled vaginal graph within an immunocompromised non-human host to create an engrafted vaginal xenograft comprising a lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method, for preparing a human tissue xenograft comprising:
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a) providing isolated human vaginal tissue;
b) configuring said human vaginal tissue so as to create a rolled vaginal graft comprising a lumen;
c) engrafting said rolled vaginal graph within an immunocompromised non-human host to create an engrafted vaginal xenograft comprising a lumen; and
d) administering one or more gonadal hormones to said immunocompromised non-human host. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification