System and method for adaptive brain stimulation
First Claim
1. A method for treating a neurological disorder in a human patient with a neurostimulator by applying electrical stimulation that is adaptive to a characteristic of an electrographic signal in the patient'"'"'s brain, the method comprising the steps of:
- measuring the characteristic of the electrographic signal;
generating a treatment waveform from the characteristic; and
applying a stimulation signal representative of the treatment waveform.
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Accused Products
Abstract
An implantable neurostimulator adapted to provide adaptive electrical brain stimulation includes a detection subsystem for isolating an electrographic signal characteristic and a stimulation system for applying an adaptive stimulation signal based at least in part upon the electrographic signal characteristic and correlated with the electrographic signal. Undesired learning of and acclimation to stimulation characteristics are avoided and stimulation efficacy is improved by adapting or otherwise varying the adaptive stimulation signal in relation to the electrographic signal.
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Citations
23 Claims
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1. A method for treating a neurological disorder in a human patient with a neurostimulator by applying electrical stimulation that is adaptive to a characteristic of an electrographic signal in the patient'"'"'s brain, the method comprising the steps of:
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measuring the characteristic of the electrographic signal;
generating a treatment waveform from the characteristic; and
applying a stimulation signal representative of the treatment waveform. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
identifying a half wave in the electrographic signal;
extracting a half wave parameter from the half wave;
transforming the half wave parameter to obtain the characteristic.
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4. The method for treating a neurological disorder of claim 3, wherein the half wave parameter comprises an amplitude or a duration.
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5. The method for treating a neurological disorder of claim 1, wherein the step of generating a treatment waveform comprises the steps of:
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selecting a stimulation signal template; and
transforming the stimulation signal template with the characteristic.
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6. The method for treating a neurological disorder of claim 5, wherein the step of transforming the stimulation signal pattern comprises altering a duration, a frequency, an inter-pulse interval, an amplitude, or a start time of the stimulation signal template.
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7. The method for treating a neurological disorder of claim 1, wherein the step of applying a stimulation signal is performed in parallel with at least one other operation performed by the neurostimulator.
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8. The method for treating a neurological disorder of claim 1, wherein the step of applying a stimulation signal comprises the steps of:
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scheduling a stimulation event;
awaiting the stimulation event; and
delivering a stimulation signal representative of the treatment waveform.
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9. The method for treating a neurological disorder of claim 1, further comprising the step of repeating the measuring, generating, and applying steps.
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10. The method for treating a neurological disorder of claim 9, wherein the stimulation signal comprises a biphasic pulse.
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11. The method for treating a neurological disorder of claim 1, further comprising the steps of:
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receiving the electrographic ;
signal with an electrode implanted in the patient'"'"'s brain; and
analyzing the signal with the neurostimulator.
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12. The method for treating a neurological disorder of claim 11, wherein the step of receiving the electrographic signal is performed in parallel with at least one other operation performed by the neurostimulator.
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13. A method for treating a neurological disorder in a human patient with a neurostimulator by applying an adaptive electrical stimulation signal, the method comprising the steps of:
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detecting a neurological event in a first electrographic signal;
measuring a characteristic of a second electrographic signal;
generating a treatment waveform from the characteristic; and
applying a stimulation signal representative of the treatment waveform to the patient'"'"'s brain. - View Dependent Claims (14, 15, 16, 17)
receiving the first electrographic signal from the patient'"'"'s brain; and
receiving the second electrographic signal from the patient'"'"'s brain.
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15. The method for treating a neurological disorder of claim 13, wherein the applying step comprises synchronizing the stimulation signal to a characteristic of a third electrographic signal.
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16. The method for treating a neurological disorder of claim 15, further comprising the step of receiving the third electrographic signal from the patient'"'"'s brain.
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17. The method for treating a neurological disorder of claim 16, wherein the first electrographic signal is obtained from a first location, the second electrographic signal is obtained from a second location, the third electrographic signal is obtained from a third location, and the applying step comprises delivering the stimulation signal at a fourth location.
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18. An implantable neurostimulator for the treatment of a neurological disorder, comprising:
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a detection subsystem adapted to detect a neurological event and to measure a characteristic of an electrographic signal;
a stimulation subsystem adapted to apply a stimulation signal to the patient'"'"'s brain, wherein the stimulation signal is representative of a treatment waveform generated at least in part from the characteristic. - View Dependent Claims (19, 20, 21, 22, 23)
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Specification