Vitamin B12 —biodegradable micro particulate conjugate carrier systems for peroral delivery of drugs, therapeutic peptides/proteins and vaccines
First Claim
1. A complex for oral delivery of drugs, therapeutic proteins and peptides, and vaccines, which are loaded in a Vitamin B12 (VB12) coupled particulate carrier system having one or more spacers in between, and having the formula VB12—
- R′
/R″
—
N, wherein each of R′ and
R″
is a spacer for the derivative of said VB12 to provide NH2, COOH, or SH group;
N is a micro or nano particle carrier for the delivery of injectable drugs, therapeutic proteins and peptides, and vaccines; and
said VB12 retains its intrinsic factor (IF) affinity after coupling to said carrier through said spacer.
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Accused Products
Abstract
The invention relates to a novel complex for oral delivery of drugs, therapeutic protein/peptides and vaccines which are loaded in a Vitamin B12 (VB12) coupled particulate carrier system with spacers in between, the carrier system with spacers having a formula VB12—R′/R″—N wherein, R′ or R″ is spacer and/or agents for derivatization of VB12 to provide either NH2 or COOH or SH groups, and N is the micro or nano particle carriers for the delivery of injectable drugs, therapeutic protein/peptides and vaccines.
19 Citations
31 Claims
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1. A complex for oral delivery of drugs, therapeutic proteins and peptides, and vaccines, which are loaded in a Vitamin B12 (VB12) coupled particulate carrier system having one or more spacers in between, and having the formula VB12—
- R′
/R″
—
N, wherein each of R′ and
R″
is a spacer for the derivative of said VB12 to provide NH2, COOH, or SH group;
N is a micro or nano particle carrier for the delivery of injectable drugs, therapeutic proteins and peptides, and vaccines; and
said VB12 retains its intrinsic factor (IF) affinity after coupling to said carrier through said spacer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
- R′
Specification