Methods and compositions for producing artificial fascia
First Claim
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1. An artificial fascia comprising:
- a polylayer of collagen-secreting cells derived from a cultured cell population on a biocompatible substrate; and
a polylayer of elastin-secreting cells derived from a second cultured cell population on the polylayer of the collagen-secreting cell population, such that the cells of the two different populations form a chimeric interface.
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Abstract
The present invention describes methods for producing artificial fascial slings and their subsequent use in treating subjects with urinary incontinence. The invention is based, in part, on the discovery that mesenchymal cells that secrete elastin and collagen, extracellular proteins responsible for elasticity and strength, respectively, can be used to engineer artificial fascia in vitro.
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Citations
24 Claims
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1. An artificial fascia comprising:
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a polylayer of collagen-secreting cells derived from a cultured cell population on a biocompatible substrate; and
a polylayer of elastin-secreting cells derived from a second cultured cell population on the polylayer of the collagen-secreting cell population, such that the cells of the two different populations form a chimeric interface. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An artificial fascia comprising:
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a polylayer of a collagen-secreting cells derived from a cultured cell population on a first surface of a biocompatible substrate; and
a polylayer of elastin-secreting cells derived from a second cultured cell population on a second surface of the biocompatible substrate, wherein the second surface is opposite the first surface. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method for producing an artificial fascia comprising:
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creating a polylayer of collagen-secreting cells derived from a cultured cell population on a biocompatible substrate; and
creating a polylayer of elastin-secreting cells derived from a second cultured cell population on the polylayer of the collagen-secreting cell population, such that the cells of the two different populations form a chimeric interface. - View Dependent Claims (14, 15, 16, 17, 18)
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19. A method for producing an artificial fascia comprising:
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creating a polylayer of a collagen-secreting cells derived from a cultured cell population on a first surface of a biocompatible substrate; and
creating a polylayer of elastin-secreting cells derived from a second cultured cell population on a second surface of the biocompatible substrate, wherein the second surface is opposite the first surface. - View Dependent Claims (20, 21, 22, 23, 24)
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Specification