Method for optimized brain stimulation for treating movement disorders

• US 6,484,059 B2
• Filed: 03/07/2001
• Issued: 11/19/2002
• Est. Priority Date: 11/05/1998
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gielen, Frans L. H.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/799,709
• Publication Number:
  US 20010008972A1
• Time in Patent Office: 622 Days
• Field of Search: 607/48, 607/45, 607/2, 128/898, 128/899, 600/544, 600/545, 600/595, 600/554
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36153 Voltage A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

There is provided apparatus and a method for testing to optimally place a deep brain lead, particularly for stimulating the GPi or other deep brain target to treat neurological disorders such as Parkinson'"'"'s Disease and the like. The invention embraces determining the location of a feedback target such as the motor cortex, the location of the deep brain target, and inserting a test lead along a substantially linear trajectory so as to be able to stimulate both concurrently. The test lead has an electrode at about its distal end for stimulation of the deep brain target, and an electrode adjustably positioned 3-8 cm proximal for stimulation of the motor cortex. When stimulation is applied concurrently through both electrodes, the affected body portion, e.g., limb, can be made to move when and if the deep brain electrode is optimally positioned. The position can be checked during surgical implant of the system, and the lead position adjusted until the optimum position is found. By use of this invention, the best lead position for the permanently implanted lead can be determined during the surgical procedure.

Claims

1. A method of testing to determine postioning of a brain stimulation lead for optimal deep brain stimulation to treat a movement disorder, said lead having MC electrode means for delivering stimulation to the motor cortex and DBS electrode means for delivering stimulation to a predetermined deep brain target, said method being carried out while said patient is under surgery for implantation of said lead, comprising:

positioning said lead along a substantially linear trajectory which includes both the patient'"'"'s motor cortex and said predetermined deep brain target;

stimulating said motor cortex and said deep brain target concurrently, and observing movement of a predetermined body part corresponding to said disorder; and

adjusting said lead to stimulate said deep brain target at a location which provides optimal stimulation for movement of said body part.

2. The method as described in claim 1, wherein said positioning comprises positioning said MC electrode means in the area of the patient'"'"'s motor cortex and positioning said DBS electrode means in the area of said patient'"'"'s deep brain target.

3. The method as described in claim 1, comprising providing said lead with a first electrode for delivering stimulus pulses to the patient'"'"'s motor cortex, said providing including adjusting the position of said electrode relative to the DBS electrode.

4. The method as described in claim 1, comprising first determining approximately a linear trajectory that encompasses both said motor cortex and said deep brain target, and drilling a burr hole in the patient'"'"'s skull along said trajectory.

5. The method as described in claim 1, comprising inserting said lead stereotactically along said trajectory.

6. The method as described in claim 1, comprising selecting the GPi as said deep brain target.

7. A method of testing to determine the optimal location of a deep brain target for stimulation of said target so as to treat a neurological disorder affecting a body part, said method comprising use of test lead means for delivering respective stimulation to a predetermined patient feedback target as well as to said deep brain target, comprising:

positioning said test lead means within a patient'"'"'s skull so that stimulation can be delivered concurrently to each of said targets;

generating first stimulation pulses and connecting said first stimulation pulses to said test lead means so as to stimulate said feedback target, and concurrently generating DBS stimulation pulses and connecting said DBS stimulation pulses to said test lead means so as to stimulate said deep brain target;

determining the movement of said body part during said concurrent stimulating;

adjusting the position of said lead means relative to said deep brain target, so as to change the efficiency of stimulation of said deep brain target, and observing the resulting movement of said body part; and

determining the optimal deep brain target location by determining when said concurrent stimulation evokes the best response of said body part.

8. The method as described in claim 7, comprising providing a single lead having MC electrode means positioned thereon for stimulating said motor cortex and DBS electrode means positioned thereon for stimulating said deep brain target, and inserting said lead into said patient'"'"'s head along a substantially linear trajectory for stimulating said motor cortex and said target.

9. The method as described in claim 7, comprising providing a first lead having MC electrode means positioned thereon for stimulating said motor cortex and inserting said first lead into said patient'"'"'s head so as to position said MC electrode means at said motor cortex, and providing a second lead having deep brain electrode means positioned thereon for stimulating said deep brain target and inserting said second lead into said patient'"'"'s head so as to position said deep brain electrode means at said deep brain target.