NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production

• US 6,484,532 B2
• Filed: 08/23/2001
• Issued: 11/26/2002
• Est. Priority Date: 06/30/1999
• Status: Expired due to Term

• Current Assignee: Polarean, Inc. (Polarean Imaging Plc)
• Original Assignee: Medi-Physics Incorporated (General Electric Company)
• Inventors: Driehuys, Bastiaan
• Primary Examiner(s): CAPOSSELA, RONALD C
• Application Number:
  US09/938,248
• Publication Number:
  US 20020029586A1
• Time in Patent Office: 460 Days
• Field of Search: 626/37, 62/555
• US Class Current: 62/637
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002

Abstract

Hyperpolarizers which produce hyperpolarized noble gases include one or more on-board NMR monitoring coils configured to monitor the polarization level of the hyperpolarized gas at various production points in the polarized gas production cycle. A dual symmetry NMR coil is positioned adjacent the optical pumping cell and is in fluid communication with a secondary reservoir in fluid communication with the polarized gas dispensing or exit flow path. This can measure the post-thaw polarization of the gas “on-board” the polarizer. Alternately or additionally, a NMR monitoring coil is assembled to the exit port portion of the optical pumping cell to give a more reliable indication of the polarization level of the gas as it flows out of the gas optical pumping cell. Another NMR monitoring coil can be positioned in a cryogenic bath adjacent a quantity of frozen polarized ¹²⁹Xe to determine the polarization level of the frozen gas.

Claims

1. A hyperpolarizer for producing polarized noble gases, comprising:

an optical pumping cell having a non-polarized gas inlet port and a polarized gas outlet port;

a magnetic field source operably associated with said optical pumping cell, said magnetic field source configured to provide a region of homogeneity;

a NMR rf coil having first and second opposing ends, said first end positioned adjacent said optical pumping cell within said region of homogeneity;

a cryogenic accumulator in fluid communication with said optical pumping cell outlet port;

a polarized gas dispensing outlet in fluid communication with said cryogenic accumulator;

a polarized gas exit flow line extending between said cryogenic accumulator and said polarized gas dispensing outlet; and

a secondary reservoir positioned adjacent said NMR rf coil second end in fluid communication with said polarized gas exit flow path;

wherein said NMR rf coil is configured and arranged between said optical cell and said secondary reservoir such that a quantity of gas positioned in either the optical cell or the secondary reservoir can be excited with said NMR rf coil.

2. A hyperpolarizer according to claim 1, wherein said magnetic field source defines a region of homogeneity which includes a portion of said optical pumping cell and a volume which extends a distance below said optical pumping cell, and wherein said NMR rf coil is positioned on a bottom portion of said optical pumping cell, and wherein said NMR rf coil and at least a portion of said secondary reservoir are positioned within said region of homogeneity.

3. A hyperpolarizer according to claim 1, wherein said secondary reservoir has an open first end and a second opposing closed end and is configured to capture a small representative volume of hyperpolarized gas therein, and wherein said closed second end is positioned in abutting contact with said NMR rf coil second end.

4. A hyperpolarizer according to claim 3, wherein said cryogenic accumulator is configured to accumulate polarized gas in a frozen phase and to release gas in a post thaw gaseous phase, and wherein said secondary reservoir is configured to receive a quantity of the post-thaw polarized gas from said gas exit flow path and position a sample of said post-thaw gas in said secondary reservoir adjacent said NMR rf coil second end.

5. A hyperpolarizer according to claim 3, wherein said secondary reservoir closed second end has a substantially planar face portion which contacts said NMR rf coil second end.

6. A hyperpolarizer according to claim 1, said hyperpolarizer further comprising a quantity of hyperpolarized gas, and wherein said polarized gas comprises hyperpolarized ¹²⁹Xe.

7. A hyperpolarizer according to claim 1, further comprising an NMR polarization detection circuit operably associated with said NMR rf coil, and wherein said NMR detection circuit is configured to detect the excitation corresponding to the polarized gas both in said optical cell and said secondary reservoir.

8. A hyperpolarizer according to claim 1, wherein said optical pumping cell has a center portion, and wherein said magnetic field source is configured such that said region of homogeneity is longitudinally offset a distance from said optical cell center portion.

9. A hyperpolarizer according to claim 1, wherein said secondary reservoir is sized to have an internal free space of less than about 5 cubic centimeters.

10. A hyperpolarizer according to claim 1, wherein said NMR rf coil is configured as a dual symmetry NMR rf coil for selectively monitoring the level of polarization associated with polarized gas in both the optical pumping cell and the secondary reservoir, said NMR rf coil comprising:

a coil body having first and second opposing flanges and an intermediate coil receiving section positioned therebetween;

a wire coil configured with a plurality of turns positioned about said intermediate coil receiving section, wherein said first flange has a first thickness and said second flange has a second thickness, and said first and second thicknesses are substantially the same, and wherein said NMR rf coil is configured and arranged to selectively monitor the level of polarization associated with two separate quantities of hyperpolarized noble gas, each being located adjacent a respective one of the first and second flanges.

11. A hyperpolarizer for producing polarized noble gases, comprising:

an optical pumping cell having a primary body having a non-polarized gas inlet port and a longitudinally extending polarized gas outlet port with an outer surface; and

an NMR rf coil having first and second opposing ends and defining a center aperture therethrough, said NMR rf coil positioned on said outlet port such that a portion of said outlet port extends through said NMR rf coil aperture, said NMR rf coil first end being positioned adjacent said primary body of said optical pumping cell,

wherein said NMR rf coil is configured such that during operation of said hyperpolarizer said NMR rf coil is able to excite a quantity of polarized gas positioned proximate to said optical cell outlet port.

12. A hyperpolarizer for producing polarized gas according to claim 11, wherein said optical pumping cell gas inlet port is separate from said outlet port, and wherein said hyperpolarizer further comprises a polarized gas dispensing outlet downstream of and in fluid communication with said optical pumping cell and an exit flow path extending from said optical cell outlet port to said polarized gas dispensing outlet, and wherein said hyperpolarizer further comprises a magnetic field source operably associated with said optical pumping cell so that said magnetic field source provides a magnetic field which spatially extends over at least a portion of said optical pumping cell, said magnetic field source configured to provide a region of homogeneity in the magnetic field which extends a distance sufficient to cover the optical cell outlet port, said region of homogeneity being sufficiently homogeneous to allow a reliable measurement of the polarization of the polarized gas proximate said optical cell outlet port.

13. A hyperpolarizer according to claim 12, further comprising a cryogenic accumulator positioned in the exit flow path such that it is in fluid communication with and intermediate of said optical cell outlet port and said dispensing outlet.

14. A hyperpolarizer according to claim 13, further comprising a secondary reservoir in fluid communication with said exit flow path and positioned relative to said exit flow path such that it is intermediate of said cryogenic accumulator and said dispensing outlet.

15. A hyperpolarizer according to claim 12, wherein said magnetic field region of homogeneity has a center location associated therewith, and wherein said an optical pumping cell primary body has a center location associated therewith, and wherein said magnetic field center is longitudinally offset from said primary body center location in a direction which is toward said optical cell outlet port.

16. A hyperpolarizer according to claim 15, further comprising a second NMR rf coil having opposing first and second sides, said second NMR rf coil positioned so as to contact said optical cell primary body on one side and said secondary reservoir on the other side to be able to selectively measure the polarization of gas held either in said secondary reservoir or said optical cell primary body.

17. A hyperpolarizer according to claim 13, wherein said cryogenic accumulator includes a polarized gas collection container in fluid communication with the optical pumping cell, said collection container having an inlet and a closed collection end, a cryogenic liquid bath, and a set of permanent magnets positioned in said cryogenic bath, and wherein said hyperpolarizer further comprises another NMR rf coil positioned in said cryogenic bath proximate to said collection end to measure the polarization of polarized gas held in said cryogenic accumulator.

18. A hyperpolarizer for producing optically pumped polarized noble gases, comprising:

an optical pumping cell having a primary body with an unpolarized gas inlet port and a polarized gas outlet port;

a cryogenic accumulator in fluid communication with said optical pumping cell outlet port, comprising;

an elongated closed end tube defining a polarized gas collection chamber for holding a quantity of collected polarized gas therein, said gas collection chamber being operably associated with first and second sealable valves, said first valve positioned upstream of said collection chamber to control the flow of gas therein and said second valve positioned downstream of said collection chamber to control the flow of gas thereout;

a cryogenic bath, wherein said collection chamber is immersed into said cryogenic bath;

a magnetic field source arranged to provide a magnetic field with a region of homogeneity adjacent said collection chamber in said cryogenic bath;

a first NMR rf coil positioned in said cryogenic bath adjacent said closed end of said tube in said magnetic field region of homogeneity, wherein said NMR rf coil is configured to have an inductance of about 0.24 mH or less;

a polarized gas-dispensing outlet in fluid communication with said cryogenic accumulator; and

a polarized gas exit flow path extending from said cryogenic accumulator to a polarized gas dispensing outlet,

wherein said first NMR rf coil is configured such that during operation of said hyperpolarizer, said first NMR rf coil monitors the level of polarization associated with the collected polarized gas held proximate to the closed end of said elongated tube.

19. A hyperpolarizer according to claim 18, said hyperpolarizer further comprising a second NMR coil positioned adjacent said optical pumping cell primary body.

20. A hyperpolarizer according to claim 19, further comprising a secondary reservoir positioned adjacent said second NMR rf coil and in fluid communication with said polarized gas exit flow path, wherein said second NMR rf coil is configured and arranged to be adjacent said optical cell and said secondary reservoir such that during operation of said hyperpolarizer said second NMR rf coil excites a quantity of polarized gas positioned in said optical cell and a quantity of polarized gas positioned in said secondary reservoir corresponding to the location of the polarized gas in the hyperpolarizer during the production cycle.

21. A hyperpolarizer according to claim 18, wherein said first NMR rf coil is configured as a solenoid longitudinally extending around a portion of the exterior of said elongated tube.

22. A hyperpolarizer according to claim 18, said cryogenic bath comprising a container with an outer wall and a quantity of cryogenic liquid held therein, and wherein said magnetic field source is a set of permanent field magnets extending about the outer wall of said cryogenic bath container adjacent said collection chamber such that said permanent field magnets are unimmersed in the liquid in said cryogenic bath.

23. A hyperpolarizer according to claim 18, wherein said magnetic field source is an electro magnet.

24. A method of monitoring the polarization level of hyperpolarized noble gas during production thereof, comprising the steps of:

polarizing a quantity of noble gas in an optical pumping chamber configured to hyperpolarize noble gas via spin-exchange with optically pumped alkali metal vapor;

directing the polarized noble gas in the optical pumping chamber to a gas flow path;

providing a magnetic field having a region of homogeneity, the region of homogeneity including at least a volume of space associated with a portion of the optical pumping chamber and the gas collection path proximate to the optical pumping chamber;

positioning a first NMR rf coil adjacent the gas flow path in the magnetic field region of homogeneity;

exciting the polarized gas by transmitting an excitation signal to the first NMR rf coil;

measuring the level of polarization associated with the hyperpolarized gas adjacent the NMR rf coil via NMR polarimetry using the NMR coil to thereby monitor the level of polarization associated with the polarized gas in a region of the polarizer adjacent the polarized gas flow path;

cryogenically accumulating the polarized gas in a cryogenic accumulator, wherein a portion of said polarized gas is frozen; and

subsequently thawing said frozen polarized gas prior to said dispensing step and after said thawing step;

wherein during or after said thawing step, a minor portion of the quantity of thawed polarized gas is directed away from a major portion of the hyperpolarized gas into the gas flow path proximate to the NMR coil.

25. A method according to claim 24, wherein the NMR rf coil is connected to an NMR detection circuit, and wherein the same NMR rf coil is used to determine the polarization of the hyperpolarized gas in the optical pumping cell and after said thawing step by the NMR rf coil positioned at a stationary location between the optical pumping cell and the gas flow path at a location downstream of the cryogenic accumulator.

26. A method according to claim 24, wherein the noble gas is ¹²⁹Xe and wherein the exciting step excites the minor portion of thawed polarized gas to provide a representative polarization level of the hyperpolarized gas after said thawing step.

27. A method according to claim 24, further comprising the step of orienting the magnetic field region of homogeneity such that the magnetic center location thereof is longitudinally offset from a center portion defined by the physical center of the optical pumping chamber in a direction toward the bottom of the optical pumping chamber so that the same NMR rf coil can be positioned within the region of homogeneity to selectively determine the polarization of the gas in the pumping cell and the gas which has been cryogenically accumulated and then thawed.