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Compositions and methods for analyte detection

  • US 6,485,703 B1
  • Filed: 07/09/1999
  • Issued: 11/26/2002
  • Est. Priority Date: 07/31/1998
  • Status: Expired due to Term
First Claim
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1. A method for the detection of an analyte in an animal, wherein the analyte is glucose, comprising the steps of:

  • (a) implanting by injecting within the epidermis or dermis of the animal a composition comprising a hydrogel and an analyte detection compound, wherein said hydrogel comprises a cross-linked poly(ethylene glycol), poly(ethylene glycol)-co-anhydride, poly(ethylene glycol)-co-lactide, poly(ethylene glycol)-co-glycolide, poly(ethylene glycol)-co-orthoester, poly-isopropylacrylamide, polyHEMA, polyacrylamide, calcium alginate, or a combination thereof; and

    wherein said detection compound is selected from the group consisting of the competitive binding pair FITC-Dextran and TRITC-ConA, or FITC-Dextran and TRITC-succinyl-ConA, (b) measuring the analyte levels.

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