Once daily pharmaceutical tablet having a unitary core
First Claim
1. A controlled release tablet which comprises:
- (a) a homogeneous compressed core which comprises;
(i) a medicament which is very slightly soluble to practically insoluble in water at 25°
C.;
(ii) a water soluble osmotic compound (iii) one or more osmotic polymers which comprise poly(ethylene oxide); and
(b) a membrane coating which completely covers said core tablet which comprises a mixture of a;
(i) a water insoluble pharmaceutically acceptable polymer; and
(ii) a pH dependent polymer such as an enteric coating polymer, the weight ratio of the pH dependent polymer to the water insoluble pharmaceutically acceptable polymer being 0.1;
1 to 0.75;
1.
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Accused Products
Abstract
A controlled release tablet is disclosed which comprises:
(a) a homogeneous compressed core which comprises:
(i) a medicament which is very slightly soluble to practically insoluble in water at 25° C.;
(ii) a water soluble osmotic compound
(iii) one or more osmotic polymers; and
(b) a membrane coating which completely covers said core tablet which comprises a mixture of a:
(i) a water insoluble pharmaceutically acceptable polymer; and
(ii) a pH dependent polymer such as an enteric coating polymer, the weight ratio of the pH dependent polymer to the water insoluble pharmaceutically acceptable polymer being 0.1:1 to 0.75:1.
A controlled release tablet which comprises:
(a) a medicament
(a) a homogeneous compressed core which comprises:
(i) a medicament;
(ii) a water soluble osmotic compound
(iii) one or more osmotic polymers; and
(b) a membrane coating which completely covers said core tablet which comprises a mixture of:
(i) a water insoluble pharmaceutically acceptable polymer; and
(ii) an enteric polymer.
93 Citations
14 Claims
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1. A controlled release tablet which comprises:
-
(a) a homogeneous compressed core which comprises;
(i) a medicament which is very slightly soluble to practically insoluble in water at 25°
C.;
(ii) a water soluble osmotic compound (iii) one or more osmotic polymers which comprise poly(ethylene oxide); and
(b) a membrane coating which completely covers said core tablet which comprises a mixture of a;
(i) a water insoluble pharmaceutically acceptable polymer; and
(ii) a pH dependent polymer such as an enteric coating polymer, the weight ratio of the pH dependent polymer to the water insoluble pharmaceutically acceptable polymer being 0.1;
1 to 0.75;
1.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A controlled release tablet which comprises:
-
(a) a homogeneous compressed core which comprises;
(i) a medicament which is very slightly soluble to practically insoluble in water at 25°
C.;
(ii) a water soluble osmotic compound (iii) poly(ethylene oxide); and
(b) a membrane coating which completely covers said core tablet which consists essentially of a mixture of a;
(i) cellulose acetate;
(ii) a plasticizer;
(iii) a water soluble channeling agent; and
(iv) poly(methacrylic acid-methylmethacrylate polymer having a 1;
2 ratio of polymethacrylic acid to methylmethacrylate and a number average molecular weight of 135,000, the weight ratio of cellulose acetate to said poly(methacrylic acid, methylmethacrylate polymer being 0.1;
1 to 0.75;
1.
-
Specification