Bio-assay device

• US 6,485,905 B2
• Filed: 08/02/1999
• Issued: 11/26/2002
• Est. Priority Date: 02/02/1998
• Status: Expired due to Term

• Current Assignee: DH Technologies Development Pte. Ltd. (Danaher Corporation)
• Original Assignee: Signature BioScience, Inc.
• Inventors: Hefti, John
• Primary Examiner(s): Chin, Christopher L.
• Application Number:
  US09/365,978
• Publication Number:
  US 20020137032A1
• Time in Patent Office: 1,212 Days
• Field of Search: 435/4, 435/6, 435/7.1, 435/7.92, 435/7.2, 435/287.1, 435/287.2, 436/517, 436/518, 436/149, 436/150, 436/151, 436/805, 436/806, 436/524, 422/82.01
• US Class Current: 435/6.11
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: H01J 49/04 Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• CPC Class Codes: Y10S 436/805 Optical property
• CPC Class Codes: Y10S 436/806 Electrical property or magnetic property

Abstract

A bio-assay test system includes a test fixture, a measurement system, and a computer. The test fixture includes a bio-assay device having a signal path and a retaining structure configured to place a sample containing molecular structures in electromagnetic communication with the signal path. The measurement system is configured to transmit test signals to and to receive test signals from the signal path at one or more predefined frequencies. The computer is configured to control the transmission and reception of the test signals to and from the measurement system.

Claims

1. A bio-assay array test system, comprising:

(1) a test fixture comprising;

(a) a bio-assay device comprising a plurality of multiple-port signal paths, each multiple-port signal path having at least one signal input port and one signal output port, the multiple-port signal path operable to support the propagation of a test signal at one or more frequencies from 10 MHz to 1000 GHz and comprising;

(i) a transmission line connected between the at least one signal input port and the at least one signal output port;

(ii) a ground element; and

(iii) a dielectric substrate attached between the transmission line and ground element; and

(b) a plurality of sample cavities, each of said sample cavities configured to retain a volume of sample adjacent to at least one of said plurality of multiple-port signal paths, whereby an input test signal propagating along the at least one multiple-port signal path is electromagnetically coupled to the adjacently located sample;

(2) a measurement system having an output connected to the at least one signal input port of the multiple-port signal path and an input connected to the at least one signal output port of the multiple-port signal path, the measurement system configured to transmit, at one or more predefined frequencies, the input test signals to one or more of the plurality of multiple-port signal paths and to receive a modulated test signals from one or more of the plurality of multiple-port signal paths; and

(3) a computer connected to the measurement system and configured to control the measurement system'"'"'s transmission of the input test signal and reception of the modulated test signal.

2. The bio-assay array test system of claim 1, wherein the at least a portion of the signal path comprises a coplanar waveguide transmission line structure.

3. The bio-assay array test system of claim 1, wherein the at least a portion of the signal path comprises a microstrip transmission line structure.

4. The bio-assay array test system of claim 1, wherein the at least a portion of the signal path comprises a coaxial transmission line structure.

5. The bio-assay array test system of claim 1, wherein the at least a portion of the signal path comprises a slotline structure.

6. The bio-assay array test system of claim 1, wherein the molecular binding region comprises a drug receptor.

7. The bio-assay array test system of claim 1, wherein the molecular binding region comprises one or more cells.