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Systems and methods for performing reactions in an unsealed environment

  • US 6,485,913 B1
  • Filed: 10/02/2000
  • Issued: 11/26/2002
  • Est. Priority Date: 03/10/1999
  • Status: Expired due to Term
First Claim
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1. A system for performing a reaction, comprising:

  • a support for performing the reaction;

    a nanoliter dispensing pipette for dispensing a submicroliter amount of a liquid onto the support;

    a temperature controlling device for regulating the temperature of the support; and

    means for controlling the amount of liquid dispensed, wherein;

    the amount of liquid dispensed corresponds to the amount of liquid that evaporates from the support; and

    the controlling means comprises software that calculates the amount of liquid that evaporates and signals the dispensing pipette to deliver an amount of liquid that corresponds to the amount that evaporates, wherein the system is open.

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