Method of inhibiting neoplastic cells with isoquinoline derivatives
First Claim
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1. A method of treating a mammal having precancerous lesions sensitive to a compound below comprising administering a pharmacologically effective amount of a compound of Formula I or pharmaceutically acceptable salt thereof:
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whereinRing A and Ring B are the same or different and each a substituted or unsubstituted benzene ring, R1 is morpholine, R2 is —
COOR3, and R3 is alkyl.
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Abstract
A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to isoquinoline derivatives.
65 Citations
2 Claims
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1. A method of treating a mammal having precancerous lesions sensitive to a compound below comprising administering a pharmacologically effective amount of a compound of Formula I or pharmaceutically acceptable salt thereof:
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wherein Ring A and Ring B are the same or different and each a substituted or unsubstituted benzene ring, R1 is morpholine, R2 is —
COOR3, and R3 is alkyl.
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2. A method for inhibiting the growth of neoplastic cells sensitive to a compound below comprising exposing the cells to a growth inhibiting effective amount of a compound of Formula I or pharmaceutically acceptable salt thereof:
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wherein Ring A and Ring B are the same or different and each a substituted or unsubstituted benzene ring, R1 is morpholine, R2 is —
COOR3, and R3 is alkyl.
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Specification
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Current AssigneeOsi Pharmaceuticals Incorporated (Astellas Pharma Incorporated)
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Original AssigneeCell Pathways, Inc. (Astellas Pharma Incorporated)
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InventorsPiazza, Gary A., Pamukcu, Rifat
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Primary Examiner(s)Goldberg, Jerome D.
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Application NumberUS09/198,413Time in Patent Office1,463 DaysField of Search514/235.2US Class Current514/235.2CPC Class CodesA61K 31/5377 not condensed and containin...
