Solutions for treating contact lenses

• US 6,486,215 B2
• Filed: 06/18/2001
• Issued: 11/26/2002
• Est. Priority Date: 07/29/1997
• Status: Expired due to Term

• Current Assignee: Alcon Research Limited (Nestle SA)
• Original Assignee: Alcon Manufacturing Limited (Alcon Incorporated)
• Inventors: Asgharian, Bahram
• Primary Examiner(s): Gitomer, Ralph
• Assistant Examiner(s): Khare, Devesh
• Application Number:
  US09/883,676
• Publication Number:
  US 20010046973A1
• Time in Patent Office: 526 Days
• Field of Search: 514/22, 514/944, 514/54, 514/839, 514/912, 536/123.1, 536/124, 536/128
• US Class Current: 424/659
• CPC Class Codes: A61L 12/08 using chemical substances
• CPC Class Codes: A61L 2/0023 Heat
• CPC Class Codes: A61L 2/04 Heat A61L2/08 takes precedence
• CPC Class Codes: C11D 17/003 Colloidal solutions, e.g. gels; Thixotropic solutions or pastes
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/042 Acids
• CPC Class Codes: C11D 3/046 Salts
• CPC Class Codes: C11D 3/222 Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
• CPC Class Codes: C11D 3/225 etherified, e.g. CMC

Abstract

Contact lens care compositions for the treatment of hard contact lenses are disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain an unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.

Claims

1. A solution for treating a contact lens, comprising:

(a) a polymer gelling system comprising a galactomannan and a borate compound in amounts effective to create a gel or partial gel when the lens is coated with the solution and the lens is placed on an eye; and

(b) water.

2. A solution according to claim 1, wherein the solution further comprises an effective amount of an ophthalmically acceptable antimicrobial agent.

3. A solution according to claim 2, wherein the antimicrobial agent is selected from the group consisting of polyquaternium-1 and polyhexamethylene biguanide.

4. A solution according to claim 1, wherein the galactomannan is selected from the group consisting of guar gum, locust bean gum, tara gum, and chemically modified derivatives thereof;

and the borate compound is selected from the group consisting of boric acid, sodium borate, potassium borate and combinations thereof.

5. A solution according to claim 4, wherein the concentration of the galactomannan in the solution is 0.1 to 2.0% (w/v) and the concentration of the borate compound is 0.05 to 2.0% (w/v).

6. A solution according to claim 5, wherein the galactomannan comprises hydroxypropyl guar and the borate compound comprises boric acid.

7. A solution according to claim 6, wherein the solution contains hydroxypropyl guar in a concentration of 0.1 to 1.0% (w/v) and boric acid in a concentration of 0.1 to 1.0% (w/v).

8. A solution according to claim 7, wherein the solution further comprises an effective amount of an ophthalmically acceptable antimicrobial agent.

9. A solution according to claim 8, wherein the antimicrobial agent is selected from the group consisting of polyquaternium-1 and polyhexamethylene biguanide.

10. A solution according to claim 9, wherein the antimicrobial agent comprises polyquaternium-1.

11. A multi-purpose solution for treating a hard contact lens, comprising:

(a) an ophthalmically acceptable antimicrobial agent in an amount effective to disinfect the lens;

(b) a polymer gelling system comprising a galactomannan and a borate compound in amounts effective to create a gel or partial gel when the lens is coated with the solution and the lens is placed on an eye; and

(c) water.

12. A multi-purpose solution according to claim 11, wherein the galactomannan is selected form the group consisting of guar gum, locust bean gum, tara gum and chemically modified derivatives thereof, and the borate compound is selected from the group consisting of boric acid, sodium borate, potassium borate and combinations thereof.

13. A multi-purpose solution according to claim 12, wherein the concentration of the galactomannan in the solution is about 0.1 to 2.0% (w/v) and the concentration of the borate compound is about 0.05 to 2.0% (w/v).

14. A multi-purpose solution according to claim 13, wherein the galactomannan comprises hydroxypropyl guar and the borate compound comprises boric acid.

15. A multi-purpose solution according to claim 14, wherein the solution contains hydroxypropyl guar in a concentration of 0.1 to 1.0% (w/v) and boric acid in a concentration of 0.1 to 1.0% (w/v).

16. A multi-purpose solution according to claim 15, wherein the antimicrobial agent comprises polyquaternium-1.

17. A solution for treating a contact lens, comprising:

(a) an amount of a galactomannan effective to condition the lens; and

(b) water.

18. A solution according to claim 17, wherein the galactomannan is selected from the group consisting of guar gum, locust bean gum, tara gum, and chemically modified derivatives thereof.

19. A solution according to claim 18, wherein the concentration of the galactomannan in the solution is 0.1 to 2.0% (w/v).

20. A solution according to claim 17, wherein the galactomannan comprises hydroxypropyl guar.

21. A solution according to claim 20, wherein the concentration of hydroxypropyl guar in the solution is 0.1 to 2.0% (w/v).

22. A solution according to claim 20, wherein the solution further comprises an ophthalmically acceptable antimicrobial agent in an amount effective to disinfect the lens.

23. A solution according to claim 22, wherein the antimicrobial agent is selected from the group consisting of polyquaternium-1 and polyhexamethylene biguanide.

24. A solution according to claim 23, wherein the antimicrobial agent comprises polyquaternium-1.

25. A solution according to claim 17, wherein the solution further comprises an ophthalmically acceptable antimicrobial agent in an amount effective to disinfect the lens.

26. A solution according to claim 25, wherein the antimicrobial agent is selected from the group consisting of polyquaternium-1 and polyhexamethylene biguanide.

27. A multi-purpose solution for cleaning, disinfecting and conditioning a contact lens, comprising:

(a) a surfactant in an mount effective to clean the lens;

(b) an amount of an ophthalmically acceptable antimicrobial agent effective to disinfect the lens;

(c) a galactomannan in an amount effective to condition the lens; and

(d) water.

28. A multi-purpose solution according to claim 27, wherein the galactomannan is selected from the group consisting of guar gum, locust bean gum, tara gum, and chemically modified derivatives thereof.

29. A solution according to claim 28, wherein the concentration of the galactomannan in the solution is 0.1 to 2.0% (w/v).

30. A solution according to claim 27, wherein the galactomannan comprises hydroxypropyl guar.

31. A solution according to claim 30, wherein the concentration of hydroxypropyl guar in the solution is 0.1 to 2.0% (w/v).

32. A solution according to claim 30, wherein the antimicrobial agent is selected from the group consisting of polyquaternium-1 and polyhexamethylene biguanide.

33. A solution according to claim 32, wherein the antimicrobial agent comprises polyquaternium-1.

34. A solution according to claim 27, wherein the antimicrobial agent is selected from the group consisting of polyquaternium-1 and. polyhexamethylene biguanide.