Optical sensor and method of operation

• US 6,488,891 B2
• Filed: 08/29/2001
• Issued: 12/03/2002
• Est. Priority Date: 01/21/1998
• Status: Expired due to Term

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Bayer Corporation (Bayer AG)
• Inventors: Sullivan, Kevin J., Mason, Richard W., Slovacek, Rudolf E.
• Primary Examiner(s): NOLAND, THOMAS
• Application Number:
  US09/941,499
• Publication Number:
  US 20020043095A1
• Time in Patent Office: 461 Days
• Field of Search: 422/58, 422/82.05, 436/8, 436/164, 436/172, 73/10.2, 732/900.1, 250/252, 702/25, 702/100
• US Class Current: 422/401
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Abstract

A multiple single use optical sensor includes a series of continuous sensor stripes deposited on a substrate web. At least one sample chamber is adapted to extend transversely across a discrete portion of the series of sensor stripes to facilitate analysis of a sample disposed therein. The sample chamber may be moved, or additional sample chambers provided to enable subsequent measurements of additional samples at unused discrete portions of the sensor stripes. The continuous nature of the sensor stripes provides consistency along the lengths thereof to enable calibration data obtained from one discrete portion of the sensor stripes to be utilized for testing an unknown sample an other discrete portion of the sensor stripes. This advantageously eliminates the need for any particular discrete portion of the sensor stripes to be contacted by more than one sample, for improved sensor performance.

Claims

1. An optical sensor assembly adapted for sensing analyte content of a plurality of samples, said optical sensor assembly comprising:

a substrate web of predetermined length, said substrate web being substantially gas impermeable and optically transparent in a predetermined spectral range;

a plurality of elongated sensor stripes extending in parallel, spaced relation along the length of said web,

each one of said plurality of sensor stripes adapted for providing an optically discernible response to presence of at least one analyte,

said optical sensor adapted for selective analyte-sensing contact with the plurality of samples, wherein each one of the plurality of samples are selectively superimposable with each one of said plurality of elongated sensor stripes at one of a plurality of discrete sample positions along the lengths thereof; and

at least one sample chamber superimposable with each of said plurality of elongated sensor stripes at one of said plurality of discrete sample positions along the lengths thereof,

said optically discernible response being substantially identical at said plurality of discrete sample positions and wherein said at least one sample chamber is adapted for alternately maintaining individual ones of the plurality of samples in said analyte-sensing contact.

2. The optical sensor as set forth in claim 1, wherein the plurality of samples comprises at least one unknown sample and at least one calibration sample, said optical sensor adapted for being calibrated upon disposition of the calibration sample in said analyte-sensing contact with said optical sensor at at least one of said plurality of discrete sample positions distinct from that of said at least one unknown sample.

3. The optical sensor as set forth in claim 1, wherein each one of said plurality of sensor stripes exhibits said optically discernible response in the presence of incident light of a predetermined spectral range.

4. The optical sensor as set forth in claim 1, further comprising a multiple single use device, wherein each one of said discrete sample positions along the lengths of said sensor stripes is adapted for analyte-sensing contact with a single one of the plurality of samples.

5. The optical sensor as set forth in claim 1, wherein the sample is a fluid and said analyte-sensing contact comprises surface-to-surface contact of the fluid with said sensor stripes.