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Methods and apparatus for template capture and normalization for submicroliter reaction

  • US 6,489,112 B1
  • Filed: 08/02/2000
  • Issued: 12/03/2002
  • Est. Priority Date: 08/02/1999
  • Status: Expired due to Fees
First Claim
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1. A method of obtaining substantially the same quantity of nucleic acid from a first and a second sample, comprising:

  • saturably binding nucleic acid from said first sample directly on an inner surface of a first capillary tube by contacting said inner surface with a solution comprising a nucleic acid and a chaotropic agent for a time sufficient for the nucleic acid to become saturably bound to said inner surface; and

    saturably binding nucleic acid from said second sample directly on an inner surface of a second capillary tube by contacting said inner surface with a solution comprising a nucleic acid and a chaotropic agent for a time sufficient for the nucleic acid to become saturably bound to said inner surface, wherein said inner surfaces of said first and second capillary tubes are capable of saturably binding substantially the same quantity of nucleic acid from each of said first and second samples, respectively.

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