Targeted separation protocols for rapid characterizations of polymers
First Claim
1. A method for targeted screening of a plurality of non-biological polymer samples, the method comprisingserially injecting four or more non-biological polymer samples into a mobile phase of a liquid chromatography system, determining whether the injected polymer samples comprise a polymer component within a predetermined molecular weight range, by separating at least one sample component of each of the four or more injected polymer samples from other sample components thereof in a column comprising a separation medium effective for targeted chromatographic separation that limits resolution to polymer molecules having molecular weights within the predetermined molecular weight range, detecting a property of the four or more non-biological polymer samples or of components thereof with a flow-though detector to identify and distinguish between the resolved portions and the unresolved portions of the samples, and screening at least one component of the resolved portions for a second property of interest with a second characterization system.
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Abstract
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
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Citations
14 Claims
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1. A method for targeted screening of a plurality of non-biological polymer samples, the method comprising
serially injecting four or more non-biological polymer samples into a mobile phase of a liquid chromatography system, determining whether the injected polymer samples comprise a polymer component within a predetermined molecular weight range, by separating at least one sample component of each of the four or more injected polymer samples from other sample components thereof in a column comprising a separation medium effective for targeted chromatographic separation that limits resolution to polymer molecules having molecular weights within the predetermined molecular weight range, detecting a property of the four or more non-biological polymer samples or of components thereof with a flow-though detector to identify and distinguish between the resolved portions and the unresolved portions of the samples, and screening at least one component of the resolved portions for a second property of interest with a second characterization system.
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8. A method for targeted screening of a plurality of non-biological polymer samples, the method comprising
serially injecting four or more non-biological polymer samples into a mobile phase of a liquid chromatography system, determining whether or not the injected polymer samples comprise a polymer component within a predetermined particle size range, by chromatographically separating at least one sample component of each of the four or more injected polymer samples from other sample components thereof in a chromatographic column comprising a separation medium effective for targeted chromatographic separation that limits resolution to polymer molecules having particle sizes within the predetermined particle size range, detecting a property of the four or more non-biological polymer samples or of components thereof with a flow-through detector to identify and distinguish between the resolved portions and the unresolved portions of the samples, and screening at least one component of the resolved portions for a second property of interest with a second characterization system.
Specification