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Targeted separation protocols for rapid characterizations of polymers

  • US 6,491,823 B1
  • Filed: 11/28/2000
  • Issued: 12/10/2002
  • Est. Priority Date: 04/03/1998
  • Status: Expired due to Term
First Claim
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1. A method for targeted screening of a plurality of non-biological polymer samples, the method comprisingserially injecting four or more non-biological polymer samples into a mobile phase of a liquid chromatography system, determining whether the injected polymer samples comprise a polymer component within a predetermined molecular weight range, by separating at least one sample component of each of the four or more injected polymer samples from other sample components thereof in a column comprising a separation medium effective for targeted chromatographic separation that limits resolution to polymer molecules having molecular weights within the predetermined molecular weight range, detecting a property of the four or more non-biological polymer samples or of components thereof with a flow-though detector to identify and distinguish between the resolved portions and the unresolved portions of the samples, and screening at least one component of the resolved portions for a second property of interest with a second characterization system.

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