Stabilization of oxidation- and/or UV-sensitive active ingredients

• US 6,491,901 B2
• Filed: 02/20/2001
• Issued: 12/10/2002
• Est. Priority Date: 02/25/2000
• Status: Expired due to Term

• Current Assignee: Beiersdorf AG (Maxingvest AG)
• Original Assignee: Beiersdorf AG (Maxingvest AG)
• Inventors: Wendel, Volker, Gers-Barlag, Heinrich, Grundt, Wiebke
• Primary Examiner(s): Dees, Jose′ G.
• Assistant Examiner(s): George, Konata M.
• Application Number:
  US09/789,245
• Publication Number:
  US 20010022966A1
• Time in Patent Office: 658 Days
• Field of Search: 424/401, 424/59
• US Class Current: 424/59
• CPC Class Codes: A61K 8/29 Titanium; Compounds thereof
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/4966 Triazines or their condensed derivatives
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

Synergistic combinations and cosmetic or dermatological formulations comprising same.

Claims

1. A cosmetic or dermatological formulation comprising an oxidation-and/or UV-sensitive light protection filter substance chosen from the group consisting of one or both in combination of 4-(tert-butyl)-4′

-methoxydibenzoylmethane and ethylhexyl p-methoxycinnamate, and a stabilizing formulation comprising a synergistic combination of 2-ethylhexyl 2-cyano-3,3-diphenylacrylate and one or more dialkyl naphthalates, wherein the 2-ethylhexyl 2-cyano-3,3-diphenylacrylate and the dialkyl naphthalates are present in a ratio of their respective weight percentages in the total formulation, of between about 0.03 to about 0.9 and the 2-ethylhexyl 2-cyano-3,3-diphenylacrylate comprises less than 3.5% of the formulation.

3. The cosmetic or dermatologic formulation of claim 1, wherein the 2-ethylhexyl 2-cyano-3,3-diphenylacrylate comprises less than 1% of the formulation.

2. A method of stabilizing a cosmetic or dermatological formulation comprising an oxidation- and/or UV-sensitive light protection filter substance chosen from the group consisting of one or both in combination of 4-(tert-butyl)-4′

-methoxydibenzoylmethane and ethylhexyl p-methoxycinnamate, comprising the step of

adding a stabilizing formulation comprising a synergistic combination of 2-ethylhexyl 2-cyano-3,3-diphenylacrylate and one or more dialkyl naphthalates, wherein the, wherein the 2-ethylhexyl 2-cyano-3,3-diphenylacrylate and the dialkyl naphthalates are present in a ratio of their respective weight percentages in the total formulation, of between about 0.03 to about 0.9 and the 2-ethylhexyl 2-cyano-3,3-diphenylacrylate comprises less than 3.5% of the formulation.

4. The method of claim 2, wherein the 2-ethylhexyl 2-cyano-3,3-diphenylacrylate comprises less than 1% of the formulation.