Treatment of myeloma bone disease with proteasomal and NF-κB activity inhibitors
First Claim
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1. A method to treat osteolytic bone destruction resulting from myeloma in a subject comprising administering to a subject in need of such treatment an effective amount of PSI or PPM-18.
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Abstract
The present invention involves the identification and use of compositions for treating myeloma bone disease. The compositions inhibit proteasomal activity and decrease the activity of the transcription factor NF-κB. Assessment of a candidate compound for its ability to inhibit production or activity of proteasomal enzymes or NF-κB provides a useful means to identify agents to treat myeloma bone disease.
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2 Claims
- 1. A method to treat osteolytic bone destruction resulting from myeloma in a subject comprising administering to a subject in need of such treatment an effective amount of PSI or PPM-18.
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