Pharmaceutical compositions and methods for use
First Claim
Patent Images
1. A compound of the formula:
-
where X, X′
, Y′ and
Y″
are individually carbon bonded to a substituent species characterized as having a sigma m value between about −
0.3 to about 0.75;
m and n are integers such that the sum of m plus n is 1, 2, 3, 4, 5 or 6;
B′
is a two carbon bridging species;
Z and Z′
are individually hydrogen or methyl; and
E, EI, EII and EIII are individually hydrogen or methyl.
1 Assignment
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Accused Products
Abstract
Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (3E)-N-methyl-4-[3-(5-nitro-6-aminopyridin)yl]-3-buten-1-amine, (3E)-N-methyl-4-[3-(5-(N-benzylcarboxamido)pyridin)yl]-3-buten-1-amine, (4E)-N-methyl-5-[5-(2-aminopyrimidin)yl]-4-penten-2-amine, (4E)-N-methyl-5-(3-(5-aminopyridin)yl)-4-penten-2-amine, (3E)-N-methyl-4-(3-(5-isobutoxypyridin)yl)-3-buten-1-amine, (3E)-N-methyl-4-(3-(1-oxopyridin)yl)-3-buten-1-amine, (3E)-N-methyl-4-(3-(5-ethylthiopyridin)yl)-3-buten-1-amine, (4E)-N-methyl-5-(3-(5-trifluoromethylpyridin)yl)-4-penten-2-amine and (4E)-N-methyl-5-(3-(5-hydroxypyridin)yl)-4-penten-2-amine.
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Citations
15 Claims
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1. A compound of the formula:
-
where X, X′
, Y′ and
Y″
are individually carbon bonded to a substituent species characterized as having a sigma m value between about −
0.3 to about 0.75;
m and n are integers such that the sum of m plus n is 1, 2, 3, 4, 5 or 6;
B′
is a two carbon bridging species;
Z and Z′
are individually hydrogen or methyl; and
E, EI, EII and EIII are individually hydrogen or methyl.- View Dependent Claims (2, 3, 4, 5)
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6. A pharmaceutical composition comprising an amount of a compound of the formula:
-
in association with a pharmaceutically acceptable carrier, where X, X′
, Y′ and
Y″
are individually carbon bonded to a substituent species characterized as having a sigma m value between about −
0.3 to about 0.75;
m and n are integers such that the sum of m plus n is 1, 2, 3, 4, 5 or 6;
B′
is a two carbon bridging species;
Z and Z′
are individually hydrogen or methyl; and
E, EI, EII and EIII are individually hydrogen or methyl.- View Dependent Claims (7, 8, 9, 10)
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11. A method for treating a disorder characterized by alteration in normal neurotransmitter release comprising administering to a subject in need thereof an effective amount of a compound of the formula:
-
where X, X′
, Y′ and
Y″
are individually carbon bonded to a substituent species characterized as having a sigma m value between about −
0.3 to about 0.75;
m and n are integers such that the sum of m plus n is 1, 2, 3, 4, 5 or 6;
B′
is a two carbon bridging species;
Z and Z′
are individually hydrogen or methyl; and
E, EI, EII and EIII are individually hydrogen or methyl.- View Dependent Claims (12, 13, 14, 15)
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Specification
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Current AssigneeTargacept, Inc. (Catalyst Biosciences, Inc.)
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Original AssigneeTargacept, Inc. (Catalyst Biosciences, Inc.)
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InventorsMiller, Craig Harrison, Dull, Gary Maurice, Caldwell, William Scott, Hadimani, Srishailkumar Basawannappa
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Primary Examiner(s)Travers, Russell
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Assistant Examiner(s)Wang, Shengjun
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Application NumberUS09/327,774Time in Patent Office1,282 DaysField of Search514/351, 514/345, 514/357, 514/358, 514/740, 514/744, 546/300US Class Current514/345CPC Class CodesA61K 31/44 Non condensed pyridines; Hy...A61K 31/4406 only substituted in positio...A61K 31/505 Pyrimidines; Hydrogenated p...C07D 213/38 having only hydrogen or hyd...C07D 213/61 Halogen atoms or nitro radi...C07D 213/65 attached in position 3 or 5C07D 213/73 Unsubstituted amino or imin...C07D 239/26 with only hydrogen atoms, h...
