Medical diagnostic ultrasound system using contrast pulse sequence imaging

• US 6,494,841 B1
• Filed: 02/29/2000
• Issued: 12/17/2002
• Est. Priority Date: 02/29/2000
• Status: Expired due to Term

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Acuson Corporation (Siemens AG)
• Inventors: Thomas, Lewis Jones, Holley, Gregory L., Phillips, Patrick, Maslak, Samuel H.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US09/514,803
• Time in Patent Office: 1,022 Days
• Field of Search: 600/443, 600/437, 600/447, 600/458
• US Class Current: 600/447
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: G01S 15/8959 using coded signals for correlation purposes
• CPC Class Codes: G01S 15/8961 using pulse compression
• CPC Class Codes: G01S 15/8981 Discriminating between fixed and moving objects or between objects moving at different speeds, e.g. wall clutter filter
• CPC Class Codes: G01S 7/52036 using analysis of echo signal for target characterisation
• CPC Class Codes: G01S 7/52039 exploiting the non-linear response of a contrast enhancer, e.g. a contrast agent diagnostic techniques involving the use of contrast agents A61B8/481
• CPC Class Codes: G01S 7/52041 detecting modification of a contrast enhancer, e.g. detecting the destruction of a contrast agent by an acoustic wave, e.g. loss of correlation diagnostic techniques involving the use of contrast agents A61B8/481

Abstract

A medical diagnostic ultrasound imaging method fires a sequence of pulses into a body and then receives, beamforms, weights and sums the resulting echo signals to suppress first order echoes. The sequence of pulses includes at least two pulses that differ in amplitude and phase. In one form, no two pulses of the sequence have the same amplitude and opposite phase. In another form, only linear echoes are suppressed. In a third form, second and third order echoes are preserved while linear echoes are suppressed.

Claims

1. A method of medical diagnostic ultrasound pulsing comprising:

firing a sequence of pulses into a body, where at least two pulses of the sequence have different amplitudes and phase, but no two pulses of the sequence have the same amplitude and opposite phase, and processing the received echoes to reject substantially linear echoes and maintain at least two nonlinear orders, at least one odd order and one even order.

2. The method of claim 1 wherein the sequence of pulses includes at least two pulses, one of which is transmitted at substantially twice the amplitude of the other.

3. The method of claim 2 wherein the sequence of pulses includes at least four pulses, two of which are transmitted at substantially twice the amplitude of the other two.

4. The method of claim 3 wherein the sequence of pulses comprises a first and a second time interleaved series of three pulses.

5. The method of claim 4 wherein each pulse of the second time interleaved series is about 90 degrees out of phase with a corresponding one of the first time interleaved series of pulses.

6. The method of claim 5 wherein the pulse sequence is 1, i, −

2, −

2i, wherein the coefficients 1 and 2 represent relative amplitudes of the pulses, the minus sign represents a phase shift of the second pulse of about 180 degrees relative to the first pulse in each of the two time interleaved series of pulses, and the i represents a phase shift of about 90 degrees between corresponding pulses of the first and second time interleaves series of pulses.

7. The method of claim 2 wherein the sequence of pulses includes at least three pulses, one of which is transmitted at substantially twice the amplitude of the other two.

8. The method of claim 7 wherein the pulse transmitted at substantially twice the amplitude of the other two pulses is substantially 180 degrees out of phase with the other two pulses.

9. The method of claim 8 wherein the pulse sequence is 1, −

2, 1, wherein the coefficients 1, 2, and 1 represent relative amplitudes of the pulses and the minus sign represents a phase shift of the second pulse of about 180°

relative to the first pulse.

10. The method of claim 7 wherein the sequence of pulses includes at least six pulses, two of which are transmitted at substantially twice the amplitude of the other four.

11. The method of claim 10 wherein the pulses comprise a first and a second time interleaved series of three pulses.

12. The method of claim 11 wherein each pulse of the second time interleaved series is about 90 degrees out of phase with a corresponding one of the first time interleaved series of pulses.

13. The method of claim 12 wherein the pulse sequence is 1, i, −

2, −

2i, 1, i, wherein the coefficients 1, 2, and 1 represent relative amplitudes of the pulses, the minus sign represents a phase shift of the second pulse of about 180 degrees relative to the first pulse in each of the two time interleaved series of pulses, and the i represents a phase shift of about 90 degrees between corresponding pulses of the first and second time interleaved series of pulses.

14. The method of claim 1 wherein the pulses of the sequence are all transmitted along a selected scan line.

15. The method of claim 1 wherein the pulses of the sequence comprise a first subset transmitted along a first scan line and a second subset transmitted along a second scan line, spatially distinct from the first scan line.

16. The method of claim 1 wherein at least one of the pulses of the sequence comprises a coded pulse.

17. The method of claim 1 wherein at least one of the pulses of the sequence comprises a chirp-coded pulse.

18. A method of medical ultrasonic processing data comprising:

(a) firing a sequence of pulses into the body, wherein at least two pulses of the sequence have different amplitude and phase from each other;

(b) receiving ultrasound echoes from scatterers in the body in response to each pulse in said sequence;

(c) weighting and summing the received echoes such that only linear echoes from scatterers are significantly suppressed.

19. The method of claim 18 wherein (c) comprises using different receive weights for signals arising from transmitted pulses with equal amplitudes but different phases.

20. The method of claim 18 wherein the pulse sequence of (a) is 0.4, −

1, 0.6, −

1, wherein coefficients 0.4, 1, and 0.6 represent relative amplitudes of the pulses and the minus sign represents a phase shift of about 180 degrees of the second and fourth pulses in the sequence relative to the first and third pulses in the sequence, and wherein (c) comprises using respective receive weights of 2.5, 3, 5, and 1.

21. The method of claim 18 wherein the pulse sequence of (a) is 0.6, −

1, 0.8, −

1, wherein coefficients 0.6, 1, and 0.8 represent relative amplitudes of the pulses and the minus sign represents a phase shift of about 180 degrees of the second and fourth pulses in the sequence relative to the first and third pulses in the sequence, and wherein (c) comprises using respective receive weights of 5/3, 3, 3.75, and 1.

22. The method of claim 18 wherein the pulse sequence is 1, +½

, −

½

, −

1, wherein coefficients 1 and ½

represent relative amplitudes of the pulses and the minus sign represents a phase shift of about 180 degrees of the third and fourth pulses in the sequence relative to the first and second pulses in the sequence, and wherein (c) comprises using respective receive weights of 3, 8, 24, −

5.

29. The method of claim 18 wherein the pulses of the sequence are all transmitted along a selected scan line.

30. The method of claim 18 wherein the pulses of the sequence comprise a first subset transmitted along a first scan line and a second subset transmitted along a second scan line, spatially distinct from the first scan line.

31. The method of claim 18 wherein the pulses are transmitted in (a) along a plurality of spatially distinct lines.

32. The method of claim 18 wherein at least one of the pulses of the sequence comprises a coded pulse, and wherein (b) comprises decoding ultrasound echoes received in response to the coded pulse.

33. The method of claim 18 wherein at least one of the pulses of the sequence comprises a chirp-coded pulse, and wherein (b) comprises decoding ultrasound echoes received in response to the chirp-coded pulse.

23. A method of medical diagnostic ultrasound pulsing comprising:

firing a sequence of pulses into a body along a scan line, where at least two pulses of the sequence have substantially the same amplitude and phase as each other, and at least two pulses of the sequence have different amplitudes from each other, and

weighting received echoes responsive to each of the pulses of the sequence with weightings;

wherein a first result of a first multiplication of a first magnitude of a first pulse with a first weight applied to the received echoes responsive to the first pulse is unequal to a second result of a second multiplication of a second magnitude of a second pulse with a second weight applied to the received echoes responsive to the second pulse.

24. The method of claim 23 wherein the at least two pulses that have different amplitudes from each other are also out of phase from each other.

25. The method of claim 24, where the at least two pulses that are out of phase are substantially 180 degrees out of phase with each other.

26. The method of claim 25 wherein the pulse sequence is 1, −

2, 1, wherein the coefficients 1, 2, and 1 represent relative amplitudes of the pulses and the minus sign represents a phase shift of the second pulse of about 180°

relative to the first pulse.

27. The method of claim 23, further comprising receiving echoes from each of the pulses in the sequence, and weighting and summing the received echoes such that only linear echoes are significantly suppressed.

28. The method of claim 23 where the pulse sequence is 1, 2, 1, wherein the coefficients 1, 2, and 1 represent relative amplitudes of the pulses, and wherein the method further comprises:

(b) receiving ultrasound echoes from scatterers in the body in response to each pulse in said sequence;

(c) weighting the received echoes with a receive weighting of 1, −

1, 1; and

(d) summing the weighted received echoes.

34. A method of medical diagnostic ultrasound imaging comprising:

(a) selecting

(i) power levels for transmitting a sequence of ultrasound pulses into a body, and

(ii) receive weights for applying to echoes received from scatterers in the body, such that the selected transmitted power levels and receive weights preserve echo information from at least second and third order scattering and suppress echo information from first order scattering;

(b) transmitting a sequence of ultrasound pulses into the body at the power levels selected in (a)(i);

(c) receiving echoes from scatterers in the body in response to each pulse in the sequence of pulses;

(d) applying the receive weights selected in (a)(ii) to the received echoes; and

(e) displaying an image based on the weighted receive echoes of (d).

35. The method of claim 34 wherein (a) includes placing at least two zeroes in the range of zero velocity plus or minus 30 cm/sec.

36. The method of claim 35 wherein (a) includes placing at least two zeroes at zero velocity.

37. The method of claim 34 wherein the pulses of the sequence are all transmitted along a selected scan line.

38. The method of claim 34 wherein the pulses of the sequence comprise a first subset transmitted along a first scan line and a second subset transmitted along a second scan line, spatially distinct from the first scan line.

39. The method of claim 34 wherein the pulses are transmitted in (b) along a plurality of spatially distinct lines.

40. The method of claim 34 wherein at least one of the pulses of the sequence comprises a coded pulse, and wherein (c) comprises decoding ultrasound echoes received in response to the coded pulse.

41. The method of claim 34 wherein at least one of the pulses of the sequence comprises a chirp-coded pulse, and wherein (c) comprises decoding ultrasound echoes received in response to the chirp-coded pulse.

42. A method of medical diagnostic ultrasound pulsing comprising firing a sequence of pulses into a body, wherein at least two pulses of the sequence differ in amplitude, wherein at least two of the pulses of the sequence differ in phase, and wherein at least a first one of the pulses of the sequence comprises a coded pulse.

44. The method of claim 42 or 43 further comprising:

(b) receiving echoes form scatterers in the body in response to each pulse in the sequence of pulses; and

(c) combining the received echoes to form a composite output signal in which at least first order echoes are suppressed.

45. The method of claim 44 wherein (b) comprises decoding echoes received in response to each coded pulse.

46. The method of claim 42 or 43 wherein each coded pulse comprises a chirp-coded pulse.

47. The method of claim 42 wherein the sequence of pulses comprises at least a second, uncoded pulse, and wherein the coded pulse is of reduced peak amplitude as compared with the uncoded pulse.

48. The method of claim 42 or 43 wherein the pulses of the sequence are all transmitted along a selected scan line.

49. The method of claim 42 or 43 wherein the pulses of the sequence comprise a first subset transmitted along a first scan line and a second subset transmitted along a second scan line, spatially distinct from the first scan line.

50. The method of claim 42 or 43 wherein the pulses are transmitted along a plurality of spatially distinct lines.

43. A method of medical ultrasonic processing comprising firing a sequence of ultrasonic pulses into a body, wherein at least two of the pulses of the sequence differ in phase, wherein at least first and second ones of the pulses are coded with codes of respective lengths, and wherein the first pulse has a larger peak amplitude and a shorter code length than the second pulse.

51. A method of medical ultrasonic processing data comprising:

(a) firing a sequence of an even number of pulses into the body, wherein at least two pulses of the sequence differ in phase from each other;

(b) receiving ultrasound echoes from scatterers in the body in response to each pulse in said sequence;

(c) weighting and summing the received echoes such that only linear echoes from scatterers are significantly suppressed;

wherein (c) comprises using different receive weights for signals arising from transmitted pulses having difference phases.

52. A method of medical diagnostic ultrasound processing comprising:

firing a sequence of at least three pulses into a body along a scan line, where at least first and second pulses of the sequence of pulses have substantially the same magnitude and phase as each other, and a third pulse of the sequence of pulses has a different magnitude than the first and second pulses; and

weighting first, second and third received echo signals responsive to the first, second and third pulses, respectively, with weights that are substantially the same.