Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
First Claim
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1. A method for inhibiting bone marrow stem cells, comprising:
- (a) administering to a subject in need thereof a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO;
2, wherein said fragment comprises the conserved Cys residues at positions 54 and 94 of SEQ ID NO;
2 and inhibits bone marrow stem cells; and
thereby (b) inhibiting bone marrow stem cells in said subject.
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Abstract
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)), as well as MPIF-1 polypeptide itself, as are vectors, host cells and recombinant methods for producing the same.
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Citations
16 Claims
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1. A method for inhibiting bone marrow stem cells, comprising:
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(a) administering to a subject in need thereof a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO;
2, wherein said fragment comprises the conserved Cys residues at positions 54 and 94 of SEQ ID NO;
2 and inhibits bone marrow stem cells; and
thereby(b) inhibiting bone marrow stem cells in said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for inhibiting bone marrow stem cells, comprising:
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(a) administering to a subject in need thereof a polypeptide comprising a fragment of human myeloid progenitor inhibitory factor-1 (MPIF-1) amino acid sequence encoded by the cDNA in ATCC Deposit No. 75676, wherein said fragment comprises the conserved Cys residues at posidbns 54 and 94 of SEQ ID NO;
2 and inhibits bone marrow stem cells; and
thereby(b) inhibiting bone marrow stem cells in said subject. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification