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Methods and compositions for treating conditions of the central and peripheral nervous systems using non-synaptic mechanisms

  • US 6,495,601 B1
  • Filed: 12/22/1999
  • Issued: 12/17/2002
  • Est. Priority Date: 12/23/1998
  • Status: Expired due to Fees
First Claim
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1. A method for treating a condition of the central nervous system in a mammalian subject in need thereof comprising delivering an effective amount of a treatment composition comprising a Na+K+Cl

  • cotransporter antagonist to the subject'"'"'s central nervous system, wherein the condition is selected from the group consisting of seizures, seizure disorders, epilepsy and status epilepticus, and wherein the treatment composition has higher activity as a glial cell ion-dependent cotransporter antagonist than as a neuronal cell ion-dependent cotransporter antagonist.

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