Membrane delivery system
First Claim
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1. A delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent in which the membrane comprises a crosslinkable polymer and a disrupting agent, in which the disrupting agent is hyaluronic acid.
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Abstract
The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent. The membrane can be used to deliver biologically active agents to the skin.
46 Citations
26 Claims
- 1. A delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent in which the membrane comprises a crosslinkable polymer and a disrupting agent, in which the disrupting agent is hyaluronic acid.
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6. A delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent, the membrane also comprising a biologically active agent, in which the biologically active agent is salicylic acid.
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7. A delivery system for topical application of a biologically active agent to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane, the membrane comprising a crosslinkable polymer selected from the group consisting of alginates, starches, and collagen;
- a crosslinking disrupting agent selected from the group consisting of breakdown products and derivatives of chitin and mucopolysaccharides; and
a biologically active agent, in which the biologically active agent is salicylic acid. - View Dependent Claims (8, 9, 10)
- a crosslinking disrupting agent selected from the group consisting of breakdown products and derivatives of chitin and mucopolysaccharides; and
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11. A delivery system for topical application of a biologically active agent to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane, the membrane comprising a crosslinkable polymer selected from the group consisting of alginates, starches, and collagen;
- a crosslinking disrupting agent selected from the group consisting of breakdown products and derivatives of chitin and mucopolysaccharides; and
a biologically active agent which is an antioxidant, in which the antioxidant is a green tea polyphenol. - View Dependent Claims (12, 13, 14)
- a crosslinking disrupting agent selected from the group consisting of breakdown products and derivatives of chitin and mucopolysaccharides; and
- 15. A method of delivering a biologically active agent to the skin which comprises applying to the skin the delivery system comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a dissolvable gel form upon the application of a wetting agent and the biologically active agent, wetting the, membrane with a wetting agent, whereby upon wetting, the membrane reverts to a dissolvable gel form, in which the wetting agent comprises at least one cosmetically acceptable acid.
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20. A kit for delivery of a biologically active agent to the skin, the kit comprising at least one freeze-dried, partially cross-linked polymeric gel membrane which reverts to a dissolvable gel form upon the application of a wetting agent;
- and a wetting agent therefor.
- View Dependent Claims (21, 22, 23, 24, 25, 26)
Specification