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Microfluidic controller and detector system with self-calibration

  • US 6,498,497 B1
  • Filed: 08/13/1999
  • Issued: 12/24/2002
  • Est. Priority Date: 10/14/1998
  • Status: Expired due to Term
First Claim
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1. A method of calibrating a plurality of electrical source channels, comprising:

  • generating a first electrical reference signal at a reference channel;

    applying the first electrical reference signal to each of the electrical source channels to generate a first electrical source signal at each of the electrical source channels;

    measuring a first electrical value at each of the reference and electrical source channels;

    generating a second electrical reference signal at the reference channel;

    applying the second electrical reference signal to each of the electrical source channels to generate a second electrical source signal at each of the electrical source channels, the second electrical reference signal and the second electrical source signal being different from the first electrical reference signal and the first electrical source signal, respectively;

    measuring a second electrical value at each of the reference and electrical source channels; and

    determining a readout calibration factor for each of the electric source channels as a function of a ratio of differences between the first and second measured reference values and between the first and second measured source values.

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