Composition for treating migraine headaches

• US 6,500,450 B1
• Filed: 04/27/2000
• Issued: 12/31/2002
• Est. Priority Date: 06/25/1998
• Status: Expired due to Term

• Current Assignee: Akeso Health Sciences, LLC
• Original Assignee: Curt Hendrix
• Inventors: Hendrix, Curt
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): FUBARA, BLESSING M
• Application Number:
  US09/560,306
• Time in Patent Office: 978 Days
• Field of Search: 435/195.1, 424/195.1, 424/439, 424/465
• US Class Current: 424/439
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

The present invention relates to a dietary supplement for the treatment of migraine headache. An extract of the feverfew plant containing parthenolide in combination with magnesium, with or without riboflavin, provided significant reduction of migraine headaches and the associated symptoms. The magnesium is present as a combination of magnesium oxide and a magnesium salt of an organic acid. The ratio of magnesium to parthenolide was about 450:1

Claims

1. A dietary supplement comprising an extract from the feverfew plant, magnesium and riboflavin, said extract containing parthenolide and the magnesium is provided as a combination of magnesium oxide, and a magnesium salt of an organic acid and the ratio of magnesium to parthenolide is at least about 430:

1.

5. The dietary supplement of claim 1 wherein the feverfew extract contains about 0.7% panthenolide.

8. The dietary supplement of claim 1 wherein a unit dose has the parthenolide present in an amount of about 0.35 milligrams per dose, the riboflavin present in an amount of about 200 milligrams per dose and the magnesium present in an amount of about 150 milligrams per dose.

9. The dietary supplement of claim 8 wherein a daily dosage is at least two unit doses.

13. The dietary supplement of claim 1 wherein one or more of the extract, magnesium and riboflavin are present in a form releasable after ingestion over a period of up to about 12 hour.

14. The dietary supplement of claim 1 further including essential oils constituting from about 0.2%_w to about 0.4%_w of the extract.

15. The dietary supplement of claim 14 wherein the extract contains from about 0.1%_w to about 0.3%_w of chrysanthenyl acetate and at least about 0.7%, parthenolide.

2. A dietary supplement comprising an extract from the feverfew plant and magnesium, said extract containing parthenolide, said magnesium being provided as a combination of magnesium oxide and a magnesium salt of an organic acid and the ratio of magnesium to parthenolide is about 430:

1.

6. The dietary supplement of claim 2 wherein the feverfew extract contains about 0.7% panthenolide.

3. A method for reducing the symptoms of migraine headaches comprising the steps of administering a therapeutically effective amount of a dietary supplement comprising an extract of the Feverfew plant, riboflavin and magnesium wherein said extract contains parthenolide and the magnesium is provided as a combination of magnesium oxide and a magnesium salt of an organic acid.

7. The method of claim 3 wherein the feverfew extract contains about 0.7% pathenolide.

4. A method of reducing the symptoms of migraine headaches comprising the steps of administering a therapeutically effective amount of a dietary supplement comprising an extract of feverfew plant, and magnesium wherein the magnesium is provided as a combination magnesium oxide and a magnesium salt of an organic acid.

10. A method of reducing the symptoms of migraine headaches comprising the steps of administering a daily dosage of a dietary supplement comprising:

0.70 milligrams of parthenolide and 300 milligrams of magnesium, wherein the magnesium is provided as a combination of magnesium oxide and a magnesium salt of an organic acid, the magnesium salt selected from the group consisting of magnesium citrate, magnesium acetate, magnesium formate, magnesium lactate, and magnesium oxalate.

11. The method of claim 10 further comprising the delivery, on a daily basis, of 400 milligrams of riboflavin.

12. A dietary supplement comprising 0.70 milligrams of parthenolide and 300 milligrams of magnesium, wherein the magnesium is provided as a combination of magnesium oxide and a magnesium salt of an organic acid, the magnesium salt selected from the group consisting of magnesium citrate, magnesium acetate, magnesium formate, magnesium methionate, magnesium aspartate, magnesium lactate, magnesium glutamate, magnesium pyrollidone carboxylate, and magnesium oxalate.

16. A method of reducing the symptoms of migraine headache comprising administering a therapeutically effective amount of parthenolide, a magnesium salt and riboflavin, the magnesium salt being provided as a salt of an organic acid.

17. The dietary supplement of claim 16 comprising 0.70 milligrams of parthenolide and 300 milligrams of magnesium wherein the magnesium is provided as a combination of magnesium oxide and a magnesium salt of an organic acid, the magnesium salt selected from the group consisting of magnesium citrate, magnesium acetate, magnesium formate, magnesium methionate, magnesium aspartate, magnesium lactate, magnesium glutamate, magnesium pyrollidone carboxylate, and magnesium oxalate.

18. The method of claim 16 wherein the parthenolide is provided by feverfew.

19. The method of claim 16 wherein the parthenolide is provided as an extract of feverfew.

20. The method of claim 16 further including magnesium oxide.

21. The method of claim 16 wherein a unit dose contains parthenolide, riboflavin and magnesium in ratios of about 200 milligrams of riboflavin, about 150 milligrams of magnesium and up to about 0.35 mg parthenolide.

22. A method of reducing the symptoms of migraine headache comprising administering a therapeutically effective amount of a composition wherein the active ingredients consist essentially of about 42.8% by weight of magnesium and about 57.1% by weight of riboflavin, the balance of the active ingredients being parthenolide.

23. The method of claim 22 wherein the parthenolide is present in a concentration of about 0.1% by weight.