Biocompatible polymer film

• US 6,500,549 B1
• Filed: 10/08/1999
• Issued: 12/31/2002
• Est. Priority Date: 10/13/1998
• Status: Expired due to Term

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro AB (Baxter International Inc.)
• Inventors: Deppisch, Reinhold, Dietrich, Ruth, Beck, Werner, Göhl, Hermann, Bauer, Ulrich, Krämer, Katja
• Primary Examiner(s): Dawson, Robert
• Assistant Examiner(s): PENG, KUO LIANG
• Application Number:
  US09/415,943
• Time in Patent Office: 1,180 Days
• Field of Search: 525/447, 525/474, 525/464, 525/453, 428/411.1, 428/425.5, 528/28, 528/59, 528/65
• US Class Current: 428/425.5
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/068 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: C08G 81/00 Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers involving only carbon-to-carbon unsaturated bond reactions C08F299/00 ; polyester-amides C08G69/44; polyester-imides C08G73/16; polyamides-imides C08G73/14; block- or graft polymers containing polysiloxane sequences C08G77/42
• CPC Class Codes: C08J 5/18 Manufacture of films or sheets
• CPC Class Codes: C08L 83/10 Block- or graft-copolymers containing polysiloxane sequences obtained by polymerising a compound having a carbon-to-carbon double bond on to a polysiloxane C08L51/08, C08L53/00
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]
• CPC Class Codes: Y10T 428/31598 Next to silicon-containing [silicone, cement, etc.] layer

Abstract

The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.

Claims

1. An article having a surface intended to contact blood, tissue or body fluids, said article having a co-polymer film covering said surface, the co-polymer film comprising a film-forming polymer component and a hydrophobic polymer block having reactive end groups, said film having a non-uniform surface characterized by domains of varied properties of hydrophobicity, roughness or hardness, said domains having average diameters in the range 0.1 nm-100 nm, wherein the film-forming polymer is selected from the group consisting of polyurethanes, polyolefin, polycarbonates, polyvinylchlorides, polysulfones, polyethersulfones, and polyamides and the hydrophobic polymer block is selected from the group consisting of siloxane polymers, fluoropolymers, plyethyleneglycol-polydimethyl siloxane co-polymers, silicone polyesters and polylactone-polysiloxane-polylactone triblock co-polymers.

2. An article according to claim 1 wherein the film-forming polymer is a polyurethane and the hydrophobic polymer block is a polylactone-polysiloxane-polylactone triblock co-polymer.

3. An article according to claim 1 wherein the film-forming polymer is a polydiphenyl methane diisocyanate prepolymer and the hydrophobic block is a polycaprolactone-polydimethylsiloxane-polycaprolactone triblock co-polymer.

4. An article according to claim 3 wherein prior to condensation, the proportion of —

OH groups on the hydrophobic block to —

NCO groups on the film-forming polymer is in the range of 0.1 to 10.0.

5. An article according to claim 1 having a first coating comprising a polyol or a polylactone-polysiloxane-polylactone triblock co-polymer, said first coating underlying the co-polymer film.

6. An article according to claim 5 further comprising an interlayer film overlying the first coating and underlying the co-polymer film.