Stable microemulsions for the administration of fatty acids to humans or to animals, and use of these microemulsions
First Claim
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1. Stable, nondetergent composition for administration to humans or animals comprising, in microemulsion form:
- from 5 to 30% by weight of one or more fatty acids with a free carboxylic acid function, as active ingredient;
from 5 to 35% by weight of one or more surfactants;
from 5 to 30% by weight of one or more C1-C12 alcohols, as cosurfactant;
from 5 to 35% by weight of one or more water-soluble compounds with a carbonyl or hydroxyl function; and
from 0 to 35% by weight of one or more water-immiscible compounds;
the composition having a pH of less than 6.5.
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Abstract
The present invention relates to a stable, nondetergent composition based on fatty acids, in microemulsion form, for administration to humans or animals, comprising:
from 5 to 30% by weight of one or more fatty acids with a free carboxylic acid function, as active ingredient;
from 5 to 35% by weight of one or more surfactants;
from 5 to 30% by weight of one or more C1-C12 alcohols, as cosurfactant;
from 5 to 35% by weight of one or more water-soluble compounds with a carbonyl or hydroxyl function; and
from 0 to 35% by weight of one or more water-immiscible compounds;
the said composition having a pH of less than 6.5.
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Citations
24 Claims
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1. Stable, nondetergent composition for administration to humans or animals comprising, in microemulsion form:
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from 5 to 30% by weight of one or more fatty acids with a free carboxylic acid function, as active ingredient;
from 5 to 35% by weight of one or more surfactants;
from 5 to 30% by weight of one or more C1-C12 alcohols, as cosurfactant;
from 5 to 35% by weight of one or more water-soluble compounds with a carbonyl or hydroxyl function; and
from 0 to 35% by weight of one or more water-immiscible compounds;
the composition having a pH of less than 6.5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 22, 23, 24)
from 10 to 30% by weight of the one or more fatty acids with a free carboxylic acid function;
from 10 to 30% by weight of the one or more nonionic or anionic surfactants;
from 5 to 25% by weight of the one or more C1-C12 alcohols; and
from 10 to 30% by weight of the one or more water-soluble compounds.
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18. Composition according to claim 1, characterized in that the one or more surfactants is
a) an anionic surfactant selected from the group consisting of alkyl sulphates in which the alkyl chain is C6-C18, alkyl benzenesulphonates in which the alkyl chain is C6-C18, and dialkyl sulphosuccinates in which the alkyl chain is C6-C18, b) a nonionic surfactant selected from the group consisting of: -
a product of condensation of an aliphatic C8-C22 fatty alcohol with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide;
a product of condensation of a (C8-C22)alkylphenol with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide;
a product of condensation of a C8-C22 fatty acid with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide;
a product of condensation of a C8-C22 fatty acid glyceride with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide;
a product of condensation of a C8-C22 fatty acid ester of sorbitol with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide;
a product of condensation of sorbitol with a C8-C22 fatty acid;
orc) a combination of the anionic surfactant and nonionic surfactant.
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19. Composition of claim 18, characterized in that the one or more surfactants is
a) the combination of a product of condensation of a C8-C22 fatty acid ester of sorbitol with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide, with a product of condensation of sorbitol with a C8-C22 fatty acid, b) the combination of a dialkyl sulphosuccinate with a product of condensation of a C8-C22 fatty acid ester of sorbitol with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide, with a product of condensation of sorbitol with a C8-C22 fatty acid, or c) the combination of an alkyl sulphate with a product of condensation of a C8-C22 fatty acid ester of sorbitol with a C2-C3 alkylene oxide in which the C2-C3 alkylene oxide is ethylene oxide, propylene oxide, or a mixture of ethylene oxide and propylene oxide, with a product of condensation of sorbitol with a C8-C22 fatty acid. -
22. Method for modifying the behavior of a human or animal, without a therapeutic or prophylactic treatment being involved, comprising administration of the composition according to claim 1 to the human or animal by bringing the composition into contact with olfactory organs through the inlet of the respiratory tract in the human or animal.
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23. Method for modifying the physiological responses in a human or animal comprising administration of the composition according to claim 1 to the human or animal by bringing the composition into contact with olfactory organs through the inlet of the respiratory tract in the human or animal.
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24. Method according to claim 22, wherein the contacting takes place via the natural respiratory mechanisms in the human or animal after spraying, nebulization, or atomization of the composition into the environment around the human or animal or after application of the composition in the environment.
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20. Stable, nondetergent composition for administration to humans or animals comprising, in microemulsion form:
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from 5 to 30% by weight of one or more fatty acids with a free carboxylic acid function, as active ingredient;
from 5 to 35% by weight of one or more surfactants;
from 5 to 30% by weight of one or more C1-C12 alcohols, as cosurfactant; and
from 5 to 35% by weight of one or more water-soluble compounds with a carbonyl or hydroxyl function;
the composition having a pH of less than 6.5.
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21. Stable, nondetergent composition for administration to humans or animals comprising, in microemulsion form:
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from 5 to 30% by weight of one or more fatty acids with a free carboxylic acid function, as active ingredient;
from 5 to 35% by weight of one or more surfactants;
from 5 to 30% by weight of one or more C1-C12 alcohols, as cosurfactant;
from 5 to 35% by weight of one or more water-soluble compounds with a carbonyl or hydroxyl function; and
from 8 to 20% by weight of one or more water-immiscible compounds;
the composition having a pH of less than 6.5.
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Specification
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Current AssigneeCeva Sante Animale SA
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Original AssigneeCeva Sante Animale SA
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InventorsZanello, Philippe
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Primary Examiner(s)Dees, Jose′ G.
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Assistant Examiner(s)Haghighatian, Mina
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Application NumberUS09/610,374Time in Patent Office909 DaysField of Search424/70.2, 424/45, 514/558, 516/58, 554/1, 554/2, 562/606US Class Current514/558CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/19 Carboxylic acids, e.g. valp...A61K 31/20 having a carboxyl group bou...A61K 9/0073 Sprays or powders for inhal...A61K 9/1075 Microemulsions or submicron...A61P 25/20 Hypnotics; SedativesA61P 25/22 Anxiolytics
