Use of borate-polyol complexes in ophthalmic compositions
DCFirst Claim
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1. An aqueous ophthalmic composition comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the composition, and water, said complex containing borate and polyol in a molar ratio of 1;
0.1 to 1;
10.
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Abstract
Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
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45 Claims
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1. An aqueous ophthalmic composition comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the composition, and water, said complex containing borate and polyol in a molar ratio of 1;
0.1 to 1;
10. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the composition, and water, said complex containing borate and polyol in a molar ratio of 1;
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21. An aqueous, unpreserved ophthalmic solution comprising an amount of a water soluble borate-polyol complex effective to enhance the antimicrobial activity of the solution.
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22. An aqueous ophthalmic solution comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water, said borate-polyol complex comprising borate and glycerin in a molar ratio of 1;
0.1 to 1;
10. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water, said borate-polyol complex comprising borate and glycerin in a molar ratio of 1;
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33. An aqueous ophthalmic solution comprising:
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water, wherein the borate-polyol complex comprises borate, propylene glycol and sorbitol and the molar ratio of borate to polyol is 1;
0.1 to 1;
10. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
- 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water, wherein the borate-polyol complex comprises borate, propylene glycol and sorbitol and the molar ratio of borate to polyol is 1;
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44. An aqueous ophthalmic solution comprising:
- a viscosity-enhancing amount of hydroxypropyl methylcellulose;
1.0 to 2.5 wt. % of a borate-polyol complex, said complex comprising boric acid and glycerin in a molar ratio of 1;
0.1 to 1;
1;
0.001 w/v % of polyquaternium-1; and
water.
- a viscosity-enhancing amount of hydroxypropyl methylcellulose;
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45. An aqueous, unpreserved ophthalmic solution comprising:
- a viscosity-enhancing effective amount of hydroxypropyl methylcellulose;
1.0 to 2.5 wt. % of a borate-polyol complex comprising boric acid, propylene glycol and sorbitol, wherein the molar ratio of borate to polyol is 1;
0.1 to 1;
1; and
water.
- a viscosity-enhancing effective amount of hydroxypropyl methylcellulose;
Specification