Triple antimicrobial composition

• US 6,503,952 B2
• Filed: 01/11/2001
• Issued: 01/07/2003
• Est. Priority Date: 11/13/1995
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Sampath, Lester, Caraos, Lauserpina A.
• Primary Examiner(s): Cook, Rebecca
• Application Number:
  US09/758,930
• Publication Number:
  US 20010016589A1
• Time in Patent Office: 726 Days
• Field of Search: 514/635, 514/643, 514/737
• US Class Current: 514/635
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof

Abstract

An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.

Claims

1. An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and polyhexamethylene biguanide;

(ii) between 0.005 and 0.1 percent of benzalkonium chloride; and

(iii) between 0.025 and 2 percent of a chlorinated phenol compound selected from the group consisting of parachlorometaxylenol and triclosan.

2. The composition of claim 1, wherein the chlorinated phenol compound is parachlorometaxylenol.

3. The composition of claim 1, wherein the chlorinated phenol compound is triclosan.

4. The composition of claim 3, wherein the antimicrobial agent is chlorhexidine free base.

5. The antimicrobial composition of claim 1 which is a cream.

6. The antimicrobial composition of claim 1 which is comprised in a disinfectant wipe.

7. A method of inhibiting the growth of bacteria on the skin of a subject in need thereof, comprising applying an effective amount of a composition according to claim 1 to said subject.

15. The composition of claim 1, further comprising between 50 and 70 percent alcohol.

8. An antimicrobial composition comprising (i) between 0.05 and 0.1 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, and polyhexamethylene biguanide;

(ii) between 0.005 and 0.1 percent of benzalkonium chloride; and

(iii) between 0.025 and 0.1 percent of a chlorinated phenol compound selected from the group consisting of parachlorometoxylenol and triclosan.

9. The composition of claim 8, wherein the chlorinated phenol compound is parachlorometaxylenol.

10. The composition of claim 8, wherein the chlorinated phenol compound is triclosan.

11. The composition of claim 10, wherein the antimicrobial agent is chlorhexidine free base.

12. The antimicrobial composition of claim 8 which is a cream.

13. The antimicrobial composition of claim 8 which is comprised in a disinfectant wipe.

14. A method of inhibiting the growth of bacteria on the skin of a subject in need thereof, comprising applying an effective amount of a composition according to claim 8 to said subject.

16. The composition of claim 8, further comprising between 50 and 70 percent alcohol.