Product irradiator for optimizing dose uniformity in products

• US 6,504,898 B1
• Filed: 04/17/2000
• Issued: 01/07/2003
• Est. Priority Date: 04/17/2000
• Status: Expired due to Fees

• Current Assignee: MDS Incorporated (Molecular Devices)
• Original Assignee: MDS Incorporated (Molecular Devices)
• Inventors: Kotler, Jiri, Borsa, Joseph
• Primary Examiner(s): Porta, David P.
• Application Number:
  US09/550,923
• Time in Patent Office: 995 Days
• Field of Search: 378/64, 378/68, 378/69, 378/208, 378/147, 378/150, 378/151, 378/95
• US Class Current: 378/64
• CPC Class Codes: G21K 5/04 with beam-forming means
• CPC Class Codes: G21K 5/10 with provision for relative movement of beam source and object to be irradiated

Abstract

An apparatus and method for irradiating a product or product stack with a relatively even radiation dose distribution (low dose uniformity ratio (DUR). The apparatus comprises a radiation source for producing radiation in the range of X-rays or greater, an adjustable collimator for producing a radiation beam of a desired geometry, a turn-table capable of receiving a product stack and a control system capable of adjusting the adjustable collimator to vary the geometry of the radiation beam as the product stack is rotated in the radiation beam. Also disclosed is the modulation of the radiation beam energy and power and varying the angular rotational velocity of the product stack in a radiation beam to achieve a low dose uniformity ratio in the product stack. The invention also discloses a radiation detection system integrated with a control system for automatic processing, and monitoring of product stacks for delivery of a precise radiation dose distribution and a relatively flat dose distribution in a product stack.

Claims

1. A product irradiator comprising:

a radiation source, an adjustable collimator, a turntable, a control system and a detection system, wherein said collimator comprises one or more radiation opaque shielding elements, and said detection system measures at least one the following parameters;

transmitted radiation, instantaneous angular velocity of said turntable, angular orientation of said turntable, power of a radiation beam produced by said radiation source, energy of said radiation beam, width of said radiation beam, collimator aperture, position of an auxiliary shield, offset of said radiation beam from the axis of rotation of said turntable, distance of said turntable from collimator, distance of said collimator from said radiation source.

2. The product irradiator of claim 1 wherein said detection system is operatively linked with said control system.

3. A method of radiation processing a product comprising:

i) placing said product onto a turntable and establishing at least one of the following properties;

length, width, height, density, and density distribution of said product;

ii) determining width for a collimated radiation beam required to produce a Dose Uniformity Ratio of from about 1 to about 2, within said product;

iii) adjusting at least one of the following parameters in phase with turntable rotation;

collimator aperture, distance between said turntable and collimator, and turntable offset, to obtain said width of a collimated radiation beam determined in step ii), wherein said width of said collimator aperture is adjusted as a function of angular orientation of said turntable;

iv) producing a collimated radiation beam using a collimator comprising one or more radiation opaque shielding elements; and

v) rotating said product within said collimated radiation beam for a period of time sufficient to achieve a minimum required radiation dose within said product.

4. A method of radiation processing a product comprising:

i) placing said product onto a turntable and establishing at least one of the following properties;

length, width, height, density, and density distribution of said product;

ii) determining width for a collimated radiation beam required to produce a Dose Uniformity Ratio of from about 1 to about 2, within said product;

iii) adjusting at least one of the following parameters in phase with turntable rotation;

collimator aperture, distance between said turntable and collimator, and turntable offset, to obtain said width of a collimated radiation beam determined in step ii), wherein an angular velocity of said turntable is a parameter that may be adjusted, and wherein said collimated radiation beam is a collimated X-ray beam produced from high energy electrons generated by an electron accelerator, and power of said high energy electrons is adjusted;

iv) producing a collimated radiation beam using a collimator comprising one or more radiation opaque shielding elements;

v) rotating said product within said collimated radiation beam for a period of time sufficient to achieve a minimum required radiation dose within said product; and

vi) detecting X-rays transmitted through said product.

5. The method of claim 4, wherein during or following said step of detecting, is:

i) processing information obtained in said detecting step by a control system and altering, if required, of any of the following parameters;

collimator aperture, distance between said turntable and collimator, turntable offset, position of auxiliary shield, angular velocity of said turntable, power of said high energy electrons.

6. A product irradiator comprising:

i) an X-ray radiation source essentially consisting of an electron accelerator for producing high energy electrons, a scanning horn by directing said high energy electrons towards a convertor, said converter for converting said high energy electrons into X-rays to produce an X-ray beam, said X-ray beam directed towards a product requiring irradiation;

ii) an adjustable collimator comprising one or more radiation opaque shielding element for shaping said X-ray beam;

iii) a turntable upon which said product is placed, wherein said turntable may be movable towards or away from said adjustable collimator, or said turntable may be movable laterally, so that an axis of rotation of said product on said turntable is offset from axis of said X-ray beam;

v) a detection system in operative association with said control system.

7. The product irradiator of claim 6, further comprising an auxiliary shield.

8. The product irradiator of claim 7, wherein said detection system measures at least one of the following parameters:

transmitted X-ray radiation, instantaneous angular velocity of said turntable, angular orientation of said turntable, power of said high energy electrons, width of high energy electron beam, energy of said X-ray beam, aperture of said adjustable collimator, position of said auxiliary shield, offset of said radiation beam from axis of rotation of said turntable, distance of said turntable from collimator, and distance of said collimator from said radiation source.