Method and apparatus for determining pulse oximetry differential values

• US 6,505,060 B1
• Filed: 09/29/2000
• Issued: 01/07/2003
• Est. Priority Date: 09/29/2000
• Status: Expired due to Term

• Current Assignee: Datex-Ohmeda Incorporated (General Electric Company)
• Original Assignee: Datex-Ohmeda Incorporated (General Electric Company)
• Inventors: Norris, Mark A.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): KREMER, MATTHEW J
• Application Number:
  US09/675,707
• Time in Patent Office: 830 Days
• Field of Search: 600/309-310, 600/322-324, 600/330, 600/336
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Differential values, for use in blood oxygenation calculations, are determined based on multiple sample values for each channel of an oximetry system, each such value constituting a data point. In one implementation, each of these data points is defined by a sample window (220, 222 and 224), where the window includes, for example, 7-10 data points. That is, the data points within window (220, 222 or 224) are used to establish a differential value nominally associated with the data sample about which the window is centered. The differential value is calculated based on a mathematical model such as a weighted linear regression analysis. In this manner, output may be provided on a sample-by-sample basis while mitigating noise sensitivity.

Claims

1. A method for use in determining a parameter value related to blood oxygenation in a pulse oximeter that provides a detector output including a series of values related to light absorption by a tissue under consideration for each of first and second centered wavelengths, the method comprising the steps of:

obtaining a first instantaneous differential value related to a first instantaneous time interval by defining a sampling window having a time dimension greater than said instantaneous time interval, said first instantaneous differential value being calculated by using at least three separate values, within said window, of said series of values related to light absorption by said tissue under consideration for said first centered wavelength, and applying different effective weights to different ones of said values within said window; and

using said first instantaneous differential value in connection with calculating said parameter value related to blood oxygenation.

2. A method as set forth in claim 1, wherein said sampling window includes said at least three separate values at said first instantaneous time interval and said sampling window has a time dimension of between about 0.1 to 0.5 seconds.

3. A method as set forth in claim 2, wherein said window has a time dimension of between about 0.25 and 0.33 seconds.

4. A method as set forth in claim 1, wherein, at said first instantaneous time interval, said sampling window includes between about 3-15 values of said series of values.

5. A method as set forth in claim 1, wherein, at said first instantaneous time interval, said sampling window includes between about 7-10 values of said series of values.

6. A method as set forth in claim 1, wherein said first instantaneous differential value is calculated by performing a best-fit function analysis relative to said at least three separate values of said series of values.

7. A method as set forth in claim 6, wherein said best-fit function analysis is a linear regression analysis.

8. A method as set forth in claim 1, wherein said effective weights are related to locations of said different ones of said values relative to said window.

9. A method as set forth in claim 1, wherein said effective weights are applied by employing a finite impulse response (FIR) filter window function to the values within the said window.

10. A method as set forth in claim 9, wherein said FIR function includes one of a box, triangle, Guassian and Blackman window function.

11. A method as set forth in claim 1, further comprising the steps of:

obtaining a second instantaneous differential value related to said first instantaneous time interval, said second instantaneous differential value being calculated using at least three separate values of said series of values related to light absorption by said tissue under consideration for said second centered wavelength; and

relating said first and second instantaneous differential values to get a data point related to said parameter values.

12. A method as set forth in claim 11, further comprising the steps of:

repeating said steps of

     1) obtaining said first instantaneous differential value and

     2) obtaining said second instantaneous differential value, for a number of additional instantaneous time intervals within a sampling period;

for said first instantaneous time interval and each of said additional instantaneous time intervals, using said first and second instantaneous differential values to obtain a data point related to said parameter value, thereby generating a set of data points for said sampling period; and

using said set of data points to obtain said parameter value.

13. A method as set forth in claim 12, wherein said step of using said set of data points comprises performing a best-fit function analysis relative to said data points.

14. A method for use in determining a parameter related to blood oxygenation in a pulse oximetry system, the oximetry system providing first detector signal information indicative of light absorption at a first wavelength over a time period by a tissue-under-test and second detector signal information indicative of light absorption at a second wavelength over the time period by the tissue-under-test, each of the first and second detector sign al information including a series of absorption related values for a corresponding series of times within said time period, said method comprising the steps of:

first determining, for each of the first and second detector signal information, a first differential value using more than one of said absorption related values;

second determining, for each of the first and second detector signal information, a second differential value using more than one of said absorption related values, wherein at least one of said absorption related values used to determine said second differential value is different than any of said absorption related values used to determine said first differential value;

said steps of first and second determining thereby yielding first and second differential values for each of said first and second detector signal information; and

third determining, using said first and second differential values for each of said first and second detector signal information, a parameter value of said parameter related to blood oxygenation;

wherein,in said steps of first and second determining, each of said first and second differential values is calculated using a first absorption related value of said series of absorption related values for a first time within said time period and a second absorption related value of said series of absorption related values for a second time within said time period, said first and second absorption related values being separated by an intervening absorption related value for an intervening time between said first and second times; and

wherein each of said steps of first and second determining comprises defining a sampling window having a time dimension less than said time period and encompassing said first and second times and said steps of first and second determining involve applying different effective weights to different ones of said values within said window.

15. A method as set forth in claim 14, wherein said sampling window has a time dimension of between about 0.1 to 0.5 seconds.

16. A method as set forth in claim 15, wherein said window has a time dimension of between about 0.25 and 0.33 seconds.

17. A method as set forth in claim 14, wherein said sampling window includes between about 3-15 values of said series of values.

18. A method as set forth in claim 14, wherein said sampling window includes between about 7-10 values of said series of values.

19. A method as set forth in claim 14, wherein each of said first and second differential values is calculated by performing a best-fit function analysis relative to said first and second absorption related values.

20. A method as set forth in claim 19, wherein said best-fit function analysis is a linear regression analysis.

21. A method as set forth in claim 14, wherein said effective weights are related to locations of said different ones of said values relative to said window.

22. A method as set forth in claim 14, wherein said effective weights are applied by employing a finite impulse response (FIR) filter window function to the values within the said window.

23. A method as set forth in claim 22, wherein said FIR function includes one of a box, triangle, Guassian and Blackman window function.

24. A pulse oximeter, comprising:

a source system for transmitting light signals relative to tissue under consideration, said light signals including a first signal having a first centered wavelength and a second signal having a second centered wavelength;

a detector system for receiving said light signals transmitted relative to said tissue under consideration and providing a series of values related to light attenuation by said tissue under consideration for each of first and second centered wavelengths; and

a processor operative for;

obtaining a first instantaneous differential value related to a first instantaneous time interval, said first instantaneous differential value being calculated using at least three separate values of said series of values related to light absorption by said tissue under consideration for said first centered wavelength; and

using said first instantaneous differential value in connection with calculating said parameter value related to blood oxygenation; and

defining a sampling window having a time dimension greater than said instantaneous time interval; and

wherein said step of obtaining said first instantaneous differential value involves applying different effective weights to different ones of said values within said window.

25. A pulse oximeter as set forth in claim 24, wherein said source system is operative for transmitting time division multiplexed signals.

26. A pulse oximeter as set forth in claim 24, wherein said source system is operative for transmitting frequency division multiplexed signals.

27. A pulse oximeter as set forth in claim 24, wherein said sampling window includes said at least three separate values at said first instantaneous time interval and said sampling window has a time dimension of between about 0.1 to 0.5 seconds.

28. A pulse oximeter as set forth in claim 27, wherein said window has a time dimension of between about 0.25 and 0.33 seconds.

29. A pulse oximeter as set forth in claim 24, wherein, at said first instantaneous time interval, said sampling window includes between about 3-15 values of said series of values.

30. A pulse oximeter as set forth in claim 24, wherein, at said first instantaneous time interval, said sampling window includes between about 7-10 values of said series of values.

31. A pulse oximeter as set forth in claim 24, wherein said first instantaneous differential value is calculated by performing a best-fit function analysis relative to said at least three separate values of said series of values.

32. A pulse oximeter as set forth in claim 31, wherein said best-fit function analysis is a linear regression analysis.

33. A pulse oximeter as set forth in claim 24, wherein said effective weights are related to locations of said different ones of said values relative to said window.

34. A pulse oximeter as set forth in claim 24, wherein said effective weights are applied by employing a finite impulse response (FIR) filter window function to the values within the said window.

35. A method as set forth in claim 34, wherein said FIR function includes one of a box, triangle, Guassian and Blackman window function.

36. A pulse oximeter as set forth in claim 24, wherein said processor is further operative for:

obtaining a second instantaneous differential value related to said first instantaneous time interval, said second instantaneous differential value being calculated using at least three separate values of said series of values related to light absorption by said tissue under consideration for said second centered wavelength; and

relating said first and second instantaneous differential values to get a data point related to said parameter values.

37. A pulse oximeter as set forth in claim 36, wherein said processor is further operative for:

repeating said steps of

     1) obtaining said first instantaneous differential value and

     2) obtaining said second instantaneous differential value, for a number of additional instantaneous time intervals within a sampling period;

for said first instantaneous time interval and each of said additional instantaneous time intervals, using said first and second instantaneous differential values to obtain a data point related to said parameter value, thereby generating a set of data points for said sampling period; and

using said set of data points to obtain said parameter value.

38. A pulse oximeter as set forth in claim 37, wherein said processor uses said set of data points by performing a best-fit function analysis relative to said data points.