System and methods for controlling distribution of acoustic energy around a focal point using a focused ultrasound system

• US 6,506,171 B1
• Filed: 07/27/2000
• Issued: 01/14/2003
• Est. Priority Date: 07/27/2000
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec-Txsonics Limited
• Inventors: Brenner, Naama, Vitek, Shuki
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): QADERI, RUNA S
• Application Number:
  US09/626,176
• Time in Patent Office: 901 Days
• Field of Search: 601/2, 601/3, 601/4, 600/439
• US Class Current: 601/2
• CPC Class Codes: A61H 23/0245 with ultrasonic transducers, e.g. piezoelectric
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 2007/027 with multiple foci created simultaneously
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G10K 11/346 using phase variation

Abstract

A focused ultrasound system includes a plurality of transducer elements disposed about and having an angular position with a central axis. Drive signals drive respective transducer elements that include phase shift values based upon the angular position of each respective transducer element. The phase shift values are based upon an oscillation function that oscillates about the central axis between minimal and maximal phase shift values such that a first on-axis focal zone and a second off-axis focal zone are created. An amplitude and frequency of the oscillation function are controlled to adjust relative acoustic energy levels of the first and second focal zones, and to adjust a radius of the second focal zone, respectively. In addition, the drive signals include an additional predetermined phase shift based upon a radial position of each respective transducer element to adjust a focal distance of the focal zones.

Claims

1. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of transducer elements disposed about a central axis, each transducer element having an angular position in a circumferential direction about the central axis;

drive circuitry coupled to the transducer elements, the drive circuitry configured for providing respective drive signals to the transducer elements; and

a controller coupled to the drive circuitry, the controller configured for controlling the drive circuitry to drive the transducer elements with respective drive signals that have phase shift values based upon the angular position of each respective transducer element, the phase shift values being based upon an oscillation function that oscillates between minimal and maximal phase shift values, and that repeats itself a predetermined number of times about the circumferential direction, the oscillation function having an amplitude defined by a difference between the minimal and maximal phase shift values that is other than an integer multiple of one hundred eighty (180) degrees.

2. The system of claim 1, wherein the transducer array comprises a spherical cap transducer array divided circumferentially into a plurality of sectors comprising the plurality of transducer elements.

3. The system of claim 2, wherein the controller is further configured for controlling the phase shift values of the respective drive signals using a step function that alternates between the minimal and maximal phase shift values for driving alternate sectors about the circumferential direction of the transducer array.

4. The system of claim 3, wherein the minimal phase shift value is zero (0) degrees and the maximal phase shift value is greater than zero (0) degrees and less than one hundred eighty (180) degrees.

5. The system of claim 1, wherein each of the transducer elements has a radial position with respect to the central axis, and wherein the minimal and maximal phase shift values are shifted by a predetermined phase shift based upon the radial positions of respective transducer elements to adjust a focal distance of a focal zone of the transducer array.

6. The system of claim 1, wherein the controller is further configured for controlling the phase shift values such that a first focal zone is created that is located on the central axis, and a second off-axis focal zone is created around the first focal zone.

7. The system of claim 6, wherein the controller is further configured for controlling the phase shift values such that a desired acoustic energy distribution is provided between the first focal zone and the second focal zone.

8. The system of claim 6, wherein the controller is further configured for selecting the predetermined number of oscillations to adjust a radius of the second focal zone.

9. A system for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, comprising:

a transducer array comprising a plurality of transducer elements disposed about a central axis, each transducer element having an angular position in a circumferential direction about the central axis;

drive circuitry coupled to the transducer elements and configured for providing respective drive signals to the transducer elements; and

a controller coupled to the drive circuitry, the controller configured for controlling phase shift values of the respective drive signals based upon a step function comprising minimal and maximal phase shift values that are applied to alternate transducer elements about the circumferential direction, the step function having an amplitude defined by a difference between the maximal and minimal phase shift values that is other than an integer multiple of one hundred eighty (180) degrees.

10. The system of claim 9, wherein the minimal phase shift value is zero (0) degrees and the maximal phase shift value is greater than zero (0) degrees and less than one hundred eighty (180) degrees.

11. The system of claim 10, wherein the controller is configured for controlling the step function such that a first focal zone is created that is located on the central axis, and a second off-axis focal zone is created around the first focal zone.

12. The system of claim 11, wherein the controller is further configured for adjusting the minimal and maximal phase shift values of the step function such that a desired acoustic energy distribution is provided between the first focal zone and the second focal zone.

13. The system of claim 11, wherein the controller is further configured for controlling a frequency of the step function such that the step function repeats itself a predetermined number of times about the circumferential direction to adjust a radius of the second focal zone.

14. The system of claim 11, wherein each of the transducer elements has a radial position with respect to the central axis, and wherein the minimal and maximal phase shift values are shifted by a predetermined phase shift based upon the radial positions of respective transducer elements to adjust a focal distance of a focal zone of the transducer array.

15. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer array comprising a plurality of transducer elements disposed about a central axis, each transducer element having an angular position in a circumferential direction about the central axis;

driving the plurality of transducer elements with respective drive signals, while substantially focusing ultrasonic energy produced by the plurality of transducer elements towards a focal plane; and

controlling phase shift values of the acoustic energy generated by each transducer element based upon an oscillation function wherein the phase shift values oscillate between minimal and maximal phase shift values based upon the angular position of the respective transducer element such that a first focal zone is generated that is located on the central axis, and a second off-axis focal zone is generated that is disposed around the first focal zone.

16. The method of claim 15, wherein the minimal phase shift value is zero (0) degrees and the maximal phase shift value is greater than zero (0) degrees and less than one hundred eighty (180) degrees.

17. The method of claim 15, wherein the step of controlling the phase shift values comprises selecting the minimal and maximal phase shift values to adjust a relative maximum acoustic intensity of the first and second focal zones.

18. The method of claim 17, wherein the minimal and maximal phase shift values are selected to optimally distribute acoustic energy between the first focal zone and the second focal zone.

19. The method of claim 15, wherein the transducer array comprises a spherical cap transducer array that is divided circumferentially into sectors comprising the plurality of transducer elements.

20. The method of claim 19, wherein the oscillation function comprises a step function that alternates between the minimal and maximal phase shift values between adjacent sectors about the circumferential direction.

21. The method of claim 15, further comprising controlling the oscillation function such that the oscillation function repeats itself a predetermined number of times about the circumferential direction.

22. The method of claim 21, wherein the predetermined number of times that the oscillation function repeats itself is adjusted to provide a desired radius of the second focal zone.

23. The method of claim 15, wherein the oscillation function approximates a sine wave, and wherein the phase shift value “

theta”

of each respective transducer element is defined by;

24. The method of claim 15, wherein each of the transducer elements has a radial position with respect to the central axis, and wherein the minimal and maximal phase shift values are shifted by a predetermined phase shift based upon the radial position of the respective transducer element.

25. The method of claim 15, wherein the step of controlling phase shift values of the acoustic energy comprises driving the transducer elements with respective drive signals that include a phase shift value that oscillates between the minimal and maximal phase shift values based upon the angular position of the respective transducer element.

26. A method for performing a therapeutic procedure in a target tissue region of a patient using focused ultrasound, the method comprising:

providing a transducer including a central axis;

providing an acoustic lens between the transducer and a focal plane, the acoustic lens comprising a plurality of regions or segments disposed about the central axis of the transducer;

driving the transducer with drive signals, while substantially focusing ultrasonic energy produced by the transducer at the focal plane; and

allowing the acoustic lens to create phase shifts in the acoustic energy emitted by the transducer and passing through respective regions or segments of the acoustic lens based upon an oscillation function that oscillates between the minimal and maximal phase shift values based upon an angular position of respective regions or segments of the acoustic lens such that a first focal zone is generated that is located on the central axis, and a second off-axis focal zone is generated that is disposed around the first focal zone.

27. The method of claim 26, wherein the acoustic lens has a varying thickness as a function of position, thereby providing the respective phase shifts.

28. The method of claim 26, wherein the step of allowing the acoustic lens to create phase shifts comprises actively controlling segments of the acoustic lens to create the phase shifts in the acoustic energy passing through the respective segments.

29. The method of claim 26, wherein the transducer comprises a multiple element transducer array, and wherein the step of driving the transducer comprises driving the transducer array with drive signals including a predetermined phase shift.