Needle-less injection system

• US 6,506,177 B2
• Filed: 10/14/1998
• Issued: 01/14/2003
• Est. Priority Date: 10/14/1998
• Status: Expired due to Fees

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Incorporated
• Inventors: Landau, Sergio
• Primary Examiner(s): Hayes, Michael J.
• Application Number:
  US09/173,071
• Publication Number:
  US 20020151839A1
• Time in Patent Office: 1,553 Days
• Field of Search: 604/68-71, 604/131, 604/133, 604/135, 604/134, 604/187
• US Class Current: 604/68
• CPC Class Codes: A61M 2005/202 cocking means, e.g. to bias the main drive spring of an injector
• CPC Class Codes: A61M 2005/3152 including gearings to multiply or attenuate the piston displacing force
• CPC Class Codes: A61M 2209/086 Docking stations
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A needle-less hypodermic jet injection system includes a hand-held injector, and an energizing or cocking unit for use with the injector to prepare it for administering an injection. The hand-held unit includes a cartridge which provides a cylinder of liquid medication to be injected, an injection orifice, and an injection piston forceful movement of which causes an injection jet of medication to be expelled from the orifice. A power unit of the injector provides for forceful movement of the injection piston when a trigger is actuated. After being used to effect an injection, the injector is interfaced with an energizer unit which cocks the power unit preparatory to the next injection.

Claims

1. A needle-less hypodermic jet injection system including a hand-held injection unit and a separate energizing unit, said hand-held injection unit being configured for administering a liquid medication in the form of a hypodermic jet injection, said injection system comprising:

a hand-held injection unit including means for mounting thereto an injection cartridge with medication cylinder, injection nozzle, and injection piston;

said hand-held injection unit also including an injection ram for driving said injection piston, a power unit which is pre-energized prior to each injection to store injection energy to be applied to the injection ram; and

a trigger mechanism allowing the energy stored in the power unit to be released and applied in driving the injection ram to cause the medication to be ejected via said injection nozzle forming the hypodermic injection jet;

said trigger mechanism including an outer trigger sleeve outwardly adapted to be manually grasped and movable axially along a portion of said hand-held injection unit, and forward movement of said outer trigger sleeve being effective to release the energy stored in the power unit; and

a separate energizing unit with which the hand-held injection unit interfaces to be energized to store injection energy so as to subsequently power an injection;

wherein said outer trigger sleeve outwardly carries a pair of diametrically opposed trigger members, each of said diametrically opposed trigger members extending outwardly relative to said hand-held injection unit, and said trigger members providing manual purchase for effecting forward movement of said outer trigger sleeve to release the energy stored in said power unit; and

wherein one of said pair of diametrically opposed trigger members pivotally carrying a release member, and said release member being pivotal between a first position interposing a safety member between said trigger sleeve and a stop member, and said safety member in a second position withdrawing said safety member from interposition between said trigger sleeve and said stop member to allow said trigger sleeve to be manually moved forward along said hand-held injection unit.

2. The injection system of claim 1 wherein said energizing unit includes a power drive, and means causing operation of said power drive upon interface of said hand-held injection unit with said energizing unit to provide stored energy in said power unit.

3. The injection system of claim 1 wherein said energizing unit includes a means for receiving force and displacement from a human while said hand-held injection unit is interfaced with said energizing unit, and for applying this force and displacement as power stored in said power unit.

4. The injection system of claim 1 wherein each of said hand-held injection unit and said energizing unit each define a respective one component of a pair of cooperative force transmitting structures, which cooperative components engage one another in force transmitting relationship upon interface of said hand-held injection unit with said energizing unit, said cooperative force transmitting structures transmitting energy from said energizing unit to said hand-held injection unit by transmission of an applied force acting over a certain distance.

5. The injection system of claim 4 wherein said hand-held injection unit includes an axially movable injector stem having a ram portion for abutting said injection piston, said injector stem being movable axially between a first position in which said power unit is discharged of energy and a second position in which said power unit stores energy for driving said ram portion to power a hypodermic jet injection, and said injector stem further includes an opposite and portion defining a respective one of said pair of force-transmitting cooperative structures.

6. The injection system of claim 5 wherein said energizing unit includes a stem which is forcefully movable, and said stem of said energizing unit having a clutch for engaging said end portion of said injector stem in force transmitting relationship, said clutch defining the other of said pair of force-transmitting cooperative structures.

7. The injection system of claim 6 wherein said end portion of said injector stem defines a circumferential groove, and said clutch of said energizing unit includes an axially extending bore for receiving said end portion and circumferential groove thereof, said clutch including at least one member which is receivable into said groove of said injector stem to couple said injector stem and clutch to transmit force between said energizing unit and said hand-held injection unit.

8. The injection system of claim 7 wherein said clutch includes a ball-clutch mechanism, and said at least one member includes a ball carried in said clutch and receivable into said groove of said injector stem to releasably lock the latter to said clutch during force transmission.

9. The injection system of claim 5 wherein said power unit includes a coil compression spring, said coil compression spring engaging said injector stern of said hand-held injection unit to forcefully drive said stem.

10. The injection system of claim 9 wherein said hand-held injection unit trigger mechanism includes a sear for engaging and holding said injector stem of said hand-held injection unit in an axial position storing energy in said coil compression spring.

11. The injection system of claim 10 wherein said trigger mechanism sear includes a second groove defined on said injector stem, and a second ball clutch carried in said hand-held injection unit and circumscribing said injector stem, said second ball clutch having at least one ball member releasably engageable into said second groove of said injector stem to retain the latter in said second position.

12. A needle-less hypodermic jet injection system including an energizing unit, and a separate hand-held injection unit, said hand-held injection unit being for use with an injection cartridge having a cylinder for receiving liquid medication, an orifice for forming the liquid into a high-velocity hypodermic injection jet, and an injection piston sealingly movable in said cylinder to displace said liquid medication via said orifice;

said needle-less injection system comprising;

a hand-held injection unit including an injection ram abutting with said injection piston of said injection cartridge to forcefully drive the latter to form an injection jet of liquid medication held in said cylinder of said cartridge, said hand-held injection unit including a power unit which is energized prior to each injection; and

a trigger mechanism allowing the energy stored in the power unit to be released and applied in driving the injection ram to cause the formation of said hypodermic injection jet;

said trigger mechanism including an outer trigger sleeve outwardly adapted to be manually grasped and movable axially along a portion of said hand-held injection unit, and forward movement of said outer trigger sleeve being effective to release the energy stored in the power unit; and

a separate energizing unit with which the hand-held injection unit interfaces prior to each injection to be energized by the application of mechanical force and displacement acting over a distance to store energy in said power unit with which to power an injection;

wherein said outer trigger sleeve outwardly carries a pair of diametrically opposed trigger members, each of said diametrically opposed trigger members extending outwardly relative to said hand-held injection unit, and said trigger members providing manual purchase for effecting forward movement of said outer trigger sleeve to release the energy stored in said power unit; and

wherein one of said pair of diametrically opposed trigger members pivotally carrying a release member, and said release member being pivotal between a first position interposing a safety member between said trigger sleeve and a stop member, and said safety member in a second position withdrawing said safety member from interposition between said trigger sleeve and said stop member to allow said trigger sleeve to be manually moved forward along said hand-held injection unit.

13. The needle-less injection system of claim 12 wherein said power unit of said hand-held injection unit includes a resilient member, said hand-held injection unit further including an injection stem which is axially movable and includes a ram portion for engaging said injection piston, said injection stem being movable axially between a first position in which said resilient member of said power unit is discharged of energy and a second position in which said power unit stores energy for driving said ram portion to power a hypodermic jet injection, and said injection stem of said hand-held injector further includes an opposite end portion defining a respective one of a pair of force-transmitting cooperative structures engageable to transmit mechanical power via said injection stem into said resilient member.

14. The needle-less injection system of claim 13 wherein said energizing unit includes a means for receiving force and displacement from a human, and the other one of a pair of force transmitting cooperative structures is engageable with said injection stem to transmit this force and displacement as power to be stored in said resilient member of said power unit.

15. The needle-free injection system of claim 14 wherein said opposite end portion of said injection stem includes an engagement surface for receiving force from said energizing unit, said energizing unit having a clutch for engaging said opposite end portion of said injector stem in force transmitting relationship, and said clutch defining the other of said pair of force transmitting cooperative structures.

16. The needle-less injection system of claim 15 wherein said opposite end portion of said injection stem defines a circumferential groove with a shoulder which forms said engagement surface, and said clutch of said energizing unit includes an axially extending bore for receiving said opposite end portion and circtunferential groove thereof, said clutch including at least one member which is receivable into said groove or said injection stem to engage said engagement surface so as to releasably couple said stem and clutch to transmit force between said energizing unit and said hand-held injection unit.

17. The injection system of claim 13 wherein said trigger mechanism sear includes a second groove defined on said injection stem, and a ball clutch carried in said hand-held injection unit and circumscribing said injection stem, said ball clutch having at least one ball member releasably engageable into said second groove of said injection stem to retain the latter in said second position.

18. The needle-less injection system of claim 12 wherein said power unit includes a coil compression spring, said coil compression spring engaging said injection stem of said hand-held injection unit to forcefully drive said stem.

19. The needle-less injection system of claim 12 wherein said injector trigger mechanism includes a trigger mechanism sear for engaging and holding said injection stem of said injector in an axial position storing energy in said coil compression spring.

20. A method of effecting a needle-less hypodermic jet injection using an injection cartridge having a cylinder for receiving liquid medication, an orifice for forming the liquid into a high-velocity hypodermic injection jet, and an injection piston movable sealingly in said cylinder to displace said liquid medication via said orifice;

said method including steps of;

providing a hand-held injection unit including an injection ram engageable with said injection piston of said injection cartridge to forcefully drive the latter to form an injection jet of liquid medication held in said cylinder of said cartridge, configuring said hand-held injection unit to include a power unit which is energized with mechanical energy prior to each injection; and

a trigger mechanism allowing the energy stored in the power unit to be released and applied in driving the injection ram to cause the formation of said hypodermic injection jet;

providing said trigger mechanism to include an outer trigger sleeve, outwardly adapting the trigger sleeve to be manually grasped and movable axially along a portion of the hand-held injection unit, and providing for forward movement of the outer trigger sleeve to be effective to release the energy stored in the power unit; and

utilizing a separate energizing unit to interface with the hand-held injection unit prior to each injection in order to re-energize the hand-held injection unit by the application of mechanical power to store energy in said power unit;

further including the steps of providing the outer trigger sleeve with a pair of diametrically opposed trigger members, extending each of the diametrically opposed trigger members outwardly on the trigger sleeve relative to the hand-held injection unit, and providing for the pair of trigger members to provide manual purchase for effecting forward movement of the outer trigger sleeve to release the energy stored in the power unit; and

further including the steps of providing for one of the pair of diametrically opposed trigger members to pivotally carry a release member, providing the release member to be pivotal between a first position interposing a safety member between the trigger sleeve and a stop member to prevent forward movement of the trigger sleeve, and providing for the safety member to in a second position withdraw the safety member from interposition between the trigger sleeve and the stop member allowing the trigger sleeve to be manually moved forward along the hand-held injection unit.

21. The needle-less injection method of claim 20 further including the step of:

providing means for receiving force and displacement from a human, and configuring said energizing unit to receive this force and displacement and to apply the same as power to be stored in said power unit while said hand-held injection unit is interfaced with said energizing unit.

22. The needle-free injection method of claim 20 further including the step of:

providing a power drive unit, and interfacing said power drive unit with said hand-held injection unit to store energy in said power unit.

23. The needle-free injection method of claim 22 in which said power drive unit includes an electric motor for providing mechanical energy to be stored in said power unit.