Multiparametric fluorescence in situ hybridization
First Claim
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1. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 4 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 15 sub-chromosomal regions.
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Abstract
The invention relates to a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said set, and (ii) being capable of specifically hybridizing with a predetermined chromosome or nucleic acid molecule, and to the use of such molecules, alone or in concert with nucleic acid amplification methods.
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97 Claims
- 1. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 4 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 15 sub-chromosomal regions.
- 14. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 4 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 15 chromosomal regions.
- 27. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 5 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 31 sub-chromosomal regions.
- 41. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 5 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 31 chromosomal regions.
- 55. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 6 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 63 sub-chromosomal regions.
- 70. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes are combinatorially linked or coupled to 6 fluorophores and said combinatorially and distinguishably labeled probes are capable of detecting 63 chromosomal regions.
- 85. A set of combinatorially and distinguishably labeled probes, wherein said set of combinatorially and distinguishably labeled probes is capable of uniquely labeling all 24 chromosome types.
Specification