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Solution phase synthesis of oligonucleotides

  • US 6,506,894 B1
  • Filed: 04/26/2000
  • Issued: 01/14/2003
  • Est. Priority Date: 08/13/1997
  • Status: Expired due to Term
First Claim
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1. A process for the preparation of a phosphorothioate triester which comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent thereby to form an H-phosphonate diester and, in situ, reacting the H-phosphonate diester with a sulfur transfer agent to produce a phosphorothioate triester.

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