Imaging apparatus

• US 6,507,687 B1
• Filed: 11/15/2000
• Issued: 01/14/2003
• Est. Priority Date: 04/09/1998
• Status: Expired due to Fees

• Current Assignee: Isis Innovation Limited
• Original Assignee: Isis Innovation Limited
• Inventors: Neil, Mark Andrew Aquilla, Wilson, Tony, Juskaitis, Rimvydas
• Primary Examiner(s): Nasri, Javaid
• Application Number:
  US09/647,539
• Time in Patent Office: 790 Days
• Field of Search: 385/115, 385/116, 385/117, 385/119
• US Class Current: 385/116
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 1/04 combined with photographic or television appliances
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: G02B 21/0024 Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
• CPC Class Codes: G02B 21/0032 Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers G02B21/0036 - G02B21/008; means for illumination of specimens in general G02B21/06
• CPC Class Codes: G02B 21/008 Details of detection or image processing, including general computer control

Abstract

The confocal imaging apparatus includes first and second light sources (6, 7) located at opposite ends of a fibre optic bundle (1). One end of the fibre optic bundle (4) is located adjacent the object to be imaged the opposite end of the fibre optic bundle (2) is located adjacent a camera (3) that records the images received from the fibre optic bundle (4). An analyser (10) is used to extract a confocal image from the image of the object produced using the illumination from the first light source (6) and the image of the object produced using illumination from the second light source (7). The imaging apparatus is particularly suited to endoscopy applications and is able to provide video rate confocal images.

Claims

1. Imaging apparatus for generating an optically sectioned image of a specimen, the imaging apparatus comprising:

a first light source;

a second light source;

a fiber optic bundle having a first end and a second end and arranged such that scattered first source light that has been scattered from said specimen when illuminated by the first light source and scattered second source light that has been scattered from said specimen when illuminated by the second light source is collected at the second end and is guided to the first end;

a lens system for focusing light from the second end of the fiber optic bundle onto said specimen and for focusing light scattered from said specimen to the second end of the fiber optic bundle; and

an analyzer for receiving light from the first end of the fiber optic bundle scattered first source light and scattered second source light and for extracting an optically sectioned image of said specimen from both the scattered first source light and the scattered second source light

wherein the fiber optic bundle is adapted to apply structure to light from the first light source that is guided by the fiber optic bundle to said specimen and wherein the second light source and the fiber optic bundle are arranged such that either the fiber optic bundle applies a structure to light from the second light source incident on said specimen which is different to the structure applied by the fiber optic bundle to light from the first light source or the fiber optic bundle applies no structure to light from the second light source incident on said specimen.

2. Imaging apparatus as claimed in claim 1, wherein the first light source is positioned at the first end of the fiber optic bundle and the second light source is positioned beyond the second end of the fiber optic bundle near to the specimen.

3. Imaging apparatus as claimed in claim 2, wherein a beam splitter is provided between the second end of the fiber optic bundle and the lens system whereby light from the second light source is introduced into a path parallel to light emerging from the second end of the fiber optic bundle.

4. Imaging apparatus as claimed in claim 1, wherein the fiber optic bundle comprises a plurality of light conduits encased in a cladding medium and light from the second light source is coupled to the cladding medium.

5. Imaging apparatus as claimed in claim 4, wherein a prism is provided for coupling light from the second light source to the cladding medium.

6. Imaging apparatus as claimed in claim 4, wherein a mask is provided at the first end of the fiber optic bundle for absorbing light propagating through the cladding medium.

7. Imaging apparatus as claimed in claim 4, wherein the second light source is located at the first end of the fiber optic bundle.

8. Imaging apparatus as claimed in claim 1, wherein the first and second light sources are lasers.

9. Imaging apparatus as claimed in claim 1, wherein the first and second light sources provide substantially identical illumination of the specimen.

10. Imaging apparatus as claimed in claim 1, wherein a focal position of the lens system is adjustable and the analyzer is adapted to produce a three dimensional image of the specimen from a plurality of sets of first and second images, each set at a different focal position.