Device and method for controlling a liquid flow

• US 6,508,273 B1
• Filed: 07/05/2001
• Issued: 01/21/2003
• Est. Priority Date: 10/15/1998
• Status: Expired due to Term

• Current Assignee: Universiteit Twente
• Original Assignee: Universiteit Twente
• Inventors: Van Den Berg, Albert
• Primary Examiner(s): CHAMBERS, A MICHAEL
• Application Number:
  US09/807,320
• Time in Patent Office: 565 Days
• Field of Search: 137/827, 137/833, 137/807, 204/454, 204/600, 204/601
• US Class Current: 137/827
• CPC Class Codes: G01N 27/44752 Controlling the zeta potential, e.g. by wall coatings
• CPC Class Codes: Y10T 137/2082 Utilizing particular fluid
• CPC Class Codes: Y10T 137/2191 By non-fluid energy field affecting input [e.g., transducer]
• CPC Class Codes: Y10T 137/2224 Structure of body of device

Abstract

The present invention relates to a device for controlling a liquid flow in a liquid channel, comprising: an elongate liquid holder in which a liquid channel is provided in longitudinal direction; first voltage means for applying a first voltage difference over substantially the longitudinal direction of the liquid channel; a conductor member arranged in at least a part of the liquid channel against the liquid holder; an insulator member arranged in the liquid channel against at least the conductor member; second voltage means for providing a second voltage difference between the conductor member and the liquid in the liquid channel; wherein the thickness of the insulator member is a maximum of 1 μm and preferably in the order of magnitude of some tens of nanometres.

Claims

1. A device for controlling the electro-osmotic flow of a liquid in a liquid channel, said device comprising:

a) an insulator member provided with an elongate liquid channel;

b) a first voltage means comprising a first electrode and a second electrode for applying a first voltage difference over substantially the longitudinal direction of the liquid channel to provide an electric field in the liquid channel;

c) a conductor member arranged between the first and second electrode on at least a part of the outer surface of the insulator member; and

d) a second voltage supply means connected to the conductor member for providing a second voltage difference between the conductor member and the liquid in the liquid channel so as to control the electro-osmotic flow of the liquid in the liquid channel, wherein;

the insulator member is fabricated with a thickness of a maximum of 1 μ

m;

the second voltage difference is a maximum of 20 V;

the first voltage means generates an electric field alternately in a first direction and in a second direction, opposite the first direction, in the liquid channel; and

the second voltage supply means switches substantially synchronously with the alternating electric field.

2. The device as claimed in claim 1, wherein the first voltage means and the second voltage supply means are directly connectable to and controllable by standard electronic elements or integrated circuits.

3. The device as claimed in claim 1, wherein the insulator member comprises a coating arranged on the conductor member, which is formed from a mechanically stable, supporting conductor material.

4. The device as claimed in claim 1, wherein both the insulator member and the conductor member are coatings arranged on a mechanically supporting material.

5. The device as claimed in claim 1, wherein the distance between the outer surface and the inner surface of the insulator member is in the order of magnitude of some tens of nanometres.

6. The device as claimed in claim 1, wherein the insulator member and the conductor member are manufactured of optically transparent.

7. The device as claimed in claim 1, wherein the insulator member is constructed from two or more insulator part-members, each of different Zeta-potential.

8. The device as claimed in claim 1, wherein two or more conductor members, to which differing voltages can be applied, are fixed to an insulator member.

9. The device as claimed in claim 1, wherein the liquid channel has a substantially rectangular cross-section.

10. The device as claimed in claim 1, wherein the liquid channel has a substantially round or semi-round cross-section.

11. The device as claimed in claim 1, wherein the first voltage means comprise two electrodes which are arranged in the liquid channel.

12. The device as claimed in claim 9, wherein the distance between the electrodes is in the order of magnitude of a few micrometers.

13. A method for manufacturing the device as claimed in claim 1, a device for controlling electro-osmotic flow of a liquid in a liquid channel, the method comprising the steps of:

etching a channel in a wafer;

depositing insulator material on the wafer;

manufacturing a glass plate;

anodic binding of the wafer on the glass plate;

etching the wafer; and

fixing a conductor member on the insulator material.

14. A system for analysis and/or synthesis of chemical solutions or suspensions, the system comprising:

at least one fluid feed channel having a gate electrode;

at least one fluid drain channel;

a pair of intermediate fluid channels connected in parallel fluid communication between each fluid feed channel and each fluid drain channel, each intermediate fluid channel including a gate electrode;

first means for applying an electrical potential across fluid received in each fluid feed channel, each fluid drain channel and the intermediate fluid channels; and

second means for applying an electrical potential to the gate electrodes of each fluid feed channel and the intermediate fluid channels concurrent with the electrical potential applied across the fluid received in each fluid feed channel, each fluid drain channel and the intermediate fluid channels, wherein the second means for applying the electrical potential applies electrical potentials to the gate electrodes which cause the fluid received in the intermediate fluid channels to circulate therein.

15. The system as claimed in claim 14, wherein the fluid circulates in the intermediate fluid channels in one of a first direction and a second direction opposite the first direction.

16. The system as claimed in claim 14, wherein the means for applying electrical potentials applies electrical potentials to the gate electrodes which cause the fluid to drain through the at least one fluid drain channel.

17. A pump system for controlling a flow of liquid supplied via a first channel to a junction formed by the intersection of the first channel with a second channel and a third channel, the pump system comprising:

a first gate electrode arranged on the first channel;

a second gate electrode arranged on the second channel;

first means for applying an electrical potential across fluid received between the first channel and the second channel; and

second means for applying an electrical potential to the first and second gate electrodes concurrent with the application of the electrical potential across the fluid received between the first channel and the second channel whereupon a pressure of the fluid between the first and second gate electrodes increases and urges the fluid received therebetween toward the third channel.

18. The pump system as set forth in claim 17, wherein the first and second gate electrodes are responsive to the second means for applying the electrical potential thereto for operating in an enhancement mode and a reversement mode, respectively, to increase the pressure of the fluid between the first and second gate electrodes.

19. The pump system as set forth in claim 18, wherein:

the first means for applying the electrical potential across the fluid received between the first channel and the second channel applies the electrical potential alternately in a first and a second, opposing direction; and

the second means for applying the electrical potential to the first and second gate electrodes switches the first and the second gate electrodes, substantially synchronously with the alternating potential, between the enhancement mode and the reversement mode.